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Welcome back to The Visser Podcast! 👋 Today, I’m diving deep into Retatrutide, often called the 'triple G' agonist, and why it's poised to be a game-changer in metabolic health and longevity. We're talking about the next frontier in weight management and beyond.
What is Retatrutide?
This groundbreaking compound targets three crucial hormones – GLP-1, GIP, and glucagon. This unique multi-hormonal approach has shown truly remarkable results, even surpassing current leading medications like tirzepatide and semaglutide in weight loss efficacy.
The Latest Clinical Insights:
In its Phase 2 trials, participants saw an average of 24.2% body weight reduction (that’s about 58 lbs!) over 48 weeks. Some even experienced up to 31% loss, which is quite significant and required careful dose management.
We're eagerly anticipating more data from the ongoing Phase 3 TRIUMPH program. Look out for results on obesity and OA knee studies coming in 2025, with further insights into obstructive sleep apnea (OSA) and type 2 diabetes expected by mid-2026. Plus, we'll see Phase 2b renal function trial results in Q4 2025.
Safety & What We Know So Far:
Like many medications in this class, common side effects include nausea and abdominal pain. The rapid weight loss observed means careful dosing is key, with some participants needing to increase caloric intake to stabilize weight. We did see one reported case of kidney stones, though its direct link to the drug is still being investigated.
Beyond Weight Loss: The Broader Benefits:
What truly excites me are the potential benefits beyond just weight loss. Early data suggests significant improvements in comorbidities like reduced knee pain, better cholesterol levels, and even improved fatty liver disease. There's promising data pointing to liver fat reduction and potential benefits for MASH (metabolic dysfunction-associated steatohepatitis).
The Competitive Edge:
Retatrutide could really solidify Eli Lilly's leadership in obesity therapeutics, potentially offering a new solution for those who haven't responded to existing therapies. It's an exciting time with new innovations like oral GLP-1 pills and once-yearly shots also in the pipeline.
Key Upcoming Milestones:
2025: Phase 3 obesity/OA knee data release.
2026: Full Phase 3 results (TRIUMPH-1/-2) and potential FDA submission.
2027: Head-to-head trial vs. tirzepatide (TRIUMPH-5).
This medication represents a significant step forward in our journey toward better health and longevity. I'll keep you updated as more data emerges!
Let me know your thoughts and questions in the comments below! 👇
Relevant Studies & Resources:
https://doi.org/10.1093/ehjcvp/pvad080
https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=915087
https://sciencehub.novonordisk.com/content/dam/sciencehub/global/en/congresses-and-scientific-publications/congresses/ow2024/Garvey/documents/Garvey_OASIS_4_OW24-oral_Final_23Oct24.pdf
https://doi.org/10.1001/jamainternmed.2024.2525
https://investor.lilly.com/news-releases/news-release-details/lillys-tirzepatide-successful-phase-3-study-showing-benefit
https://investor.lilly.com/news-releases/news-release-details/lillys-tirzepatide-was-superior-placebo-mash-resolution-and-more
https://investor.lilly.com/news-releases/news-release-details/lillys-phase-2-retatrutide-results-published-new-england-journal
https://www.boehringer-ingelheim.com/human-health/metabolic-diseases/survodutide-top-line-results-mash-fibrosis
https://ir.altimmune.com/news-releases/news-release-details/correction-altimmune-presents-results-phase-2-mri-based-body
https://investors.amgen.com/static-files/0176d78e-920b-45b3-b9cc-a727e58e80da
https://investor.lilly.com/news-releases/news-release-details/lillys-phase-2-results-published-new-england-journal-medicine
https://ir.vikingtherapeutics.com/2024-11-04-Viking-Therapeutics-Reports-New-Data-from-VK2735-Obesity-Program-at-ObesityWeek-R-2024
https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=915082
https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=915251
https://medically.roche.com/global/en/medical-material.3d8d7ba5-5a5d-4b7d-bed7-f4f5e05e5a6e.qr.html?cid
https://www.kailera.com/press-release/jiangsu-hengrui-pharmaceuticals-and-kailera-therapeutics-report-positive-topline-data-from-8-mg-dose-of-phase-2-obesity-trial-of-glp-1-gip-receptor-dual-agonist-hrs9531/
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BioKeto Gummies have gained popularity in the world of ketogenic supplements for their innovative formula designed to support a ketogenic lifestyle. These gummies are formulated to help individuals reach and maintain a state of ketosis, where the body burns fat for energy instead of carbs. In this comprehensive review, we will delve into the ingredients, benefits, and potential drawbacks of BioKeto Gummies to help you determine if they are the right choice for you.
Ingredients of BioKeto Gummies
The key ingredient in BioKeto Gummies is beta-hydroxybutyrate (BHB), a type of ketone that the body produces during fasting or when following a ketogenic diet. BHB helps jumpstart ketosis by providing the body with an alternative source of energy. In addition to BHB, BioKeto Gummies also contain natural flavors, sweeteners, and gelatin to create a delicious and convenient way to support ketosis.
Benefits of BioKeto Gummies
One of the main benefits of BioKeto Gummies is their convenience. Instead of having to measure out ketone powders or mix up shakes, you can simply grab a gummy and go. This makes it easier to stay on track with your ketogenic diet, even when you’re on the go. Additionally, the delicious flavor of the gummies can help satisfy your sweet cravings without derailing your progress.
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Potential Drawbacks of BioKeto Gummies
While BioKeto Gummies offer many benefits, there are also some potential drawbacks to consider. Some individuals may find that the gummies are not as effective as other forms of exogenous ketones, such as ketone salts or esters. Additionally, the gummies may contain added sugars or artificial ingredients that could impact your ketosis. It’s essential to read the label carefully and consult with a healthcare provider before adding BioKeto Gummies to your routine.
How to Incorporate BioKeto Gummies into Your Routine
If you decide to try BioKeto Gummies, it’s essential to incorporate them into your routine in a way that supports your overall health and wellness goals. Start by reading the recommended dosage on the packaging and gradually increasing or decreasing as needed. You may also want to track your ketone levels with a blood ketone meter to see how the gummies are affecting your ketosis. Remember that BioKeto Gummies are not a magic pill and should be used in conjunction with a balanced diet and regular exercise.
Customer Reviews of BioKeto Gummies
Many customers have reported positive experiences with BioKeto Gummies, citing increased energy levels, improved mental clarity, and easier weight management. Some users have also noted that the gummies helped them get back on track after indulging in carb-heavy meals or treats. However, as with any supplement, individual results may vary, so it’s essential to listen to your body and consult with a healthcare provider if you have any concerns.
Overall, BioKeto Gummies offer a convenient and delicious way to support ketosis and enhance your ketogenic lifestyle. By understanding the ingredients, benefits, and potential drawbacks of these gummies, you can make an informed decision about whether they are the right choice for you. Remember to prioritize your overall health and wellness goals and consult with a healthcare provider before making any changes to your routine.
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Super Health Keto Gummies You Need To Know All About It
Are you looking for a tangy and delicious addition to your ketogenic diet? Look no further than apple cider vinegar gummies! These gummies are not only a convenient way to incorporate the benefits of apple cider vinegar into your daily routine but also a tasty treat that can help support your keto lifestyle. In this article, we will explore the benefits of apple cider vinegar gummies for keto, how they can fit into your diet, and why they’re worth adding to your wellness routine.
The Benefits of Apple Cider Vinegar Gummies
Apple cider vinegar has been used for centuries for its various health benefits, and now you can enjoy those benefits in a convenient gummy form. These gummies are made from apple cider vinegar, which is fermented apples, and are often sweetened with natural ingredients like fruit juice or honey. They contain acetic acid, which has been linked to numerous health benefits such as improved digestion, weight management, and blood sugar control. Additionally, apple cider vinegar gummies are rich in antioxidants and vitamins, making them a nutritious addition to your diet.
One of the main benefits of apple cider vinegar gummies for those following a keto diet is their potential to support weight loss. The acetic acid in apple cider vinegar has been shown to increase feelings of fullness, reduce appetite, and boost metabolism, all of which can aid in weight management. By incorporating these gummies into your daily routine, you may find it easier to stay on track with your keto goals and see more consistent results.
Another advantage of apple cider vinegar gummies is their potential to improve digestion and gut health, which is crucial for overall well-being, especially on a keto diet. The acetic acid in apple cider vinegar can help balance the pH levels in your stomach, promote the growth of beneficial bacteria in your gut, and reduce bloating and indigestion. By supporting your digestive system with these gummies, you may experience fewer digestive issues and feel more comfortable as you navigate the world of keto-friendly foods.
How to Incorporate Apple Cider Vinegar Gummies into Your Diet
Now that you’re convinced of the benefits of apple cider vinegar gummies for keto, you may be wondering how to fit them into your daily routine. The good news is that these gummies are easy to incorporate, whether you enjoy them as a mid-morning snack, a post-workout treat, or a dessert after dinner. You can also take them with a meal to support digestion or when you need an extra burst of energy to power through your day. The key is to find a routine that works for you and stick to it consistently to reap the full benefits of apple cider vinegar gummies.
When choosing apple cider vinegar gummies for your keto diet, be sure to look for high-quality products that are made with organic, non-GMO ingredients and free of artificial additives. It’s also important to read the label carefully to check the sugar content and serving size to ensure they fit within your macros and won’t spike your blood sugar levels. By selecting a reputable brand that prioritizes transparency and quality, you can feel confident that you’re making a smart choice for your health and wellness.
In addition to incorporating apple cider vinegar gummies into your diet, it’s essential to maintain a well-rounded approach to keto by focusing on whole foods, staying hydrated, and getting regular exercise. While these gummies can be a helpful tool to support your keto goals, they are not a magic solution and should be part of a balanced lifestyle that includes healthy eating habits, physical activity, and self-care practices. By combining the benefits of apple cider vinegar gummies with a holistic approach to wellness, you can optimize your health and thrive on your keto journey.
Why Apple Cider Vinegar Gummies Are Worth Adding to Your Wellness Routine
As you can see, apple cider vinegar gummies are a tangy and nutritious addition to your keto diet that can offer numerous health benefits, including weight management, improved digestion, and enhanced gut health. Their convenient gummy form makes them easy to incorporate into your daily routine, whether you enjoy them as a snack, a treat, or a supplement to your meals. By selecting high-quality products and following a well-rounded approach to keto, you can harness the power of apple cider vinegar gummies to support your health and well-being.
If you’re looking for a delicious way to enhance your keto lifestyle and reap the benefits of apple cider vinegar, consider adding gummies to your wellness routine. With their sweet and tangy flavor, convenient form, and potential health benefits, these gummies are a versatile and enjoyable addition to any ketogenic diet. By making them a part of your daily routine, you can support your health and wellness goals while indulging in a tasty treat that can help you thrive on your keto journey.
FAQ
Q: Are apple cider vinegar gummies keto-friendly?
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A: Yes, apple cider vinegar gummies can be a keto-friendly option as long as they are made with keto-friendly ingredients and low in sugar. It’s essential to check the label and serving size to ensure they fit within your macros and won’t disrupt your ketosis.
Q: How many apple cider vinegar gummies should I take per day?
A: The recommended dosage of apple cider vinegar gummies can vary depending on the brand and product. It’s best to follow the instructions on the label or consult with a healthcare professional to determine the right dosage for your individual needs and goals.
Q: Can apple cider vinegar gummies help with weight loss on keto?
A: Apple cider vinegar gummies have been linked to weight management benefits, including appetite suppression, increased metabolism, and improved digestion, which can support weight loss on a keto diet. By incorporating these gummies into your daily routine, you may experience enhanced results and a more satisfying keto journey.
Q: Are there any side effects of taking apple cider vinegar gummies?
A: While apple cider vinegar gummies are generally safe for most people, some individuals may experience side effects such as digestive issues, throat irritation, or allergic reactions. It’s essential to start with a small dosage and monitor your body’s response to determine if these gummies are right for you.
Q: How long does it take to see the benefits of apple cider vinegar gummies?
A: The time it takes to see the benefits of apple cider vinegar gummies can vary depending on your individual health status, diet, and lifestyle factors. Some people may notice improvements in digestion, weight management, and energy levels within a few weeks, while others may take longer to experience significant changes. It’s important to be patient and consistent with your consumption of apple cider vinegar gummies to maximize their potential benefits.
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Semaglutide is a medication that has gained popularity in recent years for its potential to aid in weight loss. It is a glucagon-like peptide-1 (GLP-1) agonist that works by increasing feelings of fullness, slowing down stomach emptying, and reducing appetite. While many people have found success in using semaglutide for weight loss, it is essential to be aware of the potential adverse effects that may come with its use.
Cardiovascular Effects
One potential adverse effect of semaglutide for weight loss is its impact on the cardiovascular system. Some studies have shown an increased risk of heart-related issues such as heart attack, stroke, and heart failure in individuals taking semaglutide. It is crucial to monitor your cardiovascular health closely while using this medication and consult with your healthcare provider if you experience any symptoms of heart problems.
Furthermore, individuals with a history of cardiovascular disease should proceed with caution when considering semaglutide for weight loss, as it may exacerbate existing heart issues or increase the risk of developing new ones.
It is essential to discuss your medical history and any pre-existing cardiovascular conditions with your healthcare provider before starting treatment with semaglutide to ensure your safety and well-being.
Gastrointestinal Disturbances
Another common adverse effect of semaglutide for weight loss is gastrointestinal disturbances. These may include symptoms such as nausea, vomiting, diarrhea, and constipation. These side effects typically occur during the initial weeks of treatment as your body adjusts to the medication.
If you experience severe or persistent gastrointestinal symptoms while taking semaglutide, it is crucial to talk to your healthcare provider. They may be able to adjust your dosage or recommend strategies to help alleviate these side effects.
Managing gastrointestinal disturbances while using semaglutide for weight loss may involve making dietary changes, staying hydrated, and taking over-the-counter medications to relieve symptoms. Your healthcare provider can provide guidance on how to address these issues effectively.
Hypoglycemia
Semaglutide can lower blood sugar levels, potentially leading to a condition called hypoglycemia. Symptoms of hypoglycemia may include shakiness, sweating, confusion, dizziness, and irritability. It is essential to monitor your blood sugar levels regularly while taking semaglutide, especially if you have diabetes or are at risk for hypoglycemia.
If you experience symptoms of hypoglycemia while using semaglutide for weight loss, it is crucial to manage your blood sugar levels promptly. Consuming fast-acting carbohydrates such as glucose tablets, juice, or candy can help raise your blood sugar levels quickly and alleviate symptoms.
Your healthcare provider can provide you with a personalized plan for managing hypoglycemia while taking semaglutide. It is essential to follow their recommendations closely to prevent serious complications associated with low blood sugar levels.
Renal Impairment
Individuals with pre-existing renal impairment may be at an increased risk of experiencing adverse effects while using semaglutide for weight loss. The medication is excreted through the kidneys, so impaired renal function can affect its clearance from the body and increase the risk of toxicity.
If you have kidney disease or are at risk for renal impairment, it is vital to discuss this with your healthcare provider before starting treatment with semaglutide. They may need to adjust your dosage or monitor your kidney function more closely to ensure the medication is safe for you to use.
Your healthcare provider may recommend regular blood tests to assess your kidney function while taking semaglutide. If any signs of renal impairment are detected, they can make appropriate adjustments to your treatment plan to protect your kidney health.
Psychiatric Effects
Semaglutide may have psychiatric effects on some individuals, including symptoms of depression, anxiety, and mood changes. It is essential to monitor your mental well-being while using this medication and seek help if you experience any concerning psychiatric symptoms.
If you have a history of mental health conditions or are at risk for psychiatric effects, it is crucial to discuss this with your healthcare provider before starting treatment with semaglutide. They can provide guidance on how to manage any potential psychiatric side effects and ensure your mental well-being is protected.
Your healthcare provider may recommend regular mental health assessments while taking semaglutide to monitor for any signs of psychiatric effects. It is essential to communicate openly with them about your mental health to receive the support and care you need during treatment.
In conclusion, while semaglutide can be an effective tool for weight loss, it is essential to be aware of the potential adverse effects it may cause. By staying informed, monitoring your health closely, and working closely with your healthcare provider, you can maximize the benefits of semaglutide for weight loss while minimizing the risks of adverse effects.
Remember to report any unusual symptoms or concerns to your healthcare provider promptly to ensure your safety and well-being while using semaglutide for weight loss.
By being proactive and informed, you can make the most of your weight loss journey with semaglutide and achieve your health goals effectively and safely.
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