Understanding Semaglutides Mechanism For Weight Loss
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The newest generation of GLP-1 drugs are being hailed by some as “miracle drugs” for the treatment of obesity. But GLP-1s are expensive, insurance coverage is limited, and not everyone with obesity can and or wants to take them. In this episode, which is based on Goldman Sachs Research’s latest Top of Mind report, obesity medicine physician Dr. Fatima Cody Stanford and Jonathan Gruber, professor of economics and chairman of the Economics Department at MIT, discuss how large the addressable market for GLP-1s actually is and the implications for US fiscal health.
Dates of recording
March 25, 27, April 16, 2024
This podcast should not be copied, distributed, published or reproduced, in whole or in part. The information contained in this recording was obtained from publicly available sources, has not been independently verified by Goldman Sachs, may not be current, and Goldman Sachs has no obligation to provide any updates or changes. All price references and market forecasts are as of the date of recording. This podcast is not a product of Goldman Sachs Global Investment Research and the information contained in this podcast is not financial research. The views and opinions expressed in this podcast are not necessarily those of Goldman Sachs and may differ from the views and opinions of other departments or divisions of Goldman Sachs and its affiliates. Goldman Sachs is not providing any financial, economic, legal, accounting, or tax advice or recommendations in this podcast. The information contained in this podcast does not constitute investment advice or an offer to buy or sell securities from any Goldman Sachs entity to the listener and should not be relied upon to evaluate any potential transaction. In addition, the receipt of this podcast by any listener is not to be taken to constitute such person a client of any Goldman Sachs entity. Neither Goldman Sachs nor any of its affiliates makes any representation or warranty, express or implied, as to the accuracy or completeness of the statements or any information contained in this podcast and any liability therefore (including in respect of direct, indirect or consequential loss or damage) is expressly disclaimed.
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Ask any gym buff what the most difficult part about working-out is and chances are they'll say it's losing fat quickly. A major detriment to working-out consistently is boredom brought about by lack of motivation. Of course, results will come even slower by skipping gym sessions regularly.
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As obesity rates continue to rise globally, the search for effective weight loss solutions has become more urgent. Semaglutide, a medication originally designed to treat type 2 diabetes, has recently emerged as a potential tool for weight loss. In clinical trials, semaglutide injections have been shown to help individuals shed pounds when combined with diet and exercise. However, like any medication, semaglutide is not without its side effects. It is important for individuals considering this treatment to be aware of the potential risks and benefits before starting a semaglutide weight loss program.
Common Side Effects
One of the most common side effects of semaglutide injections for weight loss is nausea. This symptom typically occurs in the early stages of treatment and may subside over time as the body adjusts to the medication. Some individuals may also experience vomiting, diarrhea, or constipation. These gastrointestinal side effects are usually mild to moderate in severity and can often be managed with lifestyle changes or other medications.
Another common side effect of semaglutide is decreased appetite. While this can be a positive outcome for individuals trying to lose weight, it may also lead to unintended weight loss or nutritional deficiencies if not monitored closely. Some individuals may also experience headaches, dizziness, or fatigue while taking semaglutide. These symptoms are usually temporary and should improve with continued use of the medication.
Rare but Serious Side Effects
Although rare, some individuals may experience more serious side effects while taking semaglutide for weight loss. These can include pancreatitis, kidney problems, or allergic reactions. Symptoms of pancreatitis may include severe abdominal pain, nausea, and vomiting. Individuals experiencing these symptoms should seek medical attention immediately. Kidney problems may manifest as changes in urine output, swelling of the legs or feet, or difficulty breathing. Allergic reactions to semaglutide may present as rash, itching, or difficulty swallowing or breathing. If any of these symptoms occur, individuals should stop taking semaglutide and contact their healthcare provider.
Drug Interactions and Precautions
Before starting a semaglutide weight loss program, individuals should disclose all medications they are currently taking to their healthcare provider. Semaglutide may interact with certain medications, including insulin and oral diabetes drugs. Additionally, individuals with a history of pancreatitis, thyroid problems, or gastrointestinal disorders should use semaglutide with caution. Pregnant or breastfeeding women should not use semaglutide for weight loss, as its safety in these populations has not been established.
Individuals with a history of depression or suicidal thoughts should be closely monitored while taking semaglutide, as some studies have suggested a potential link between the medication and mood disorders. It is important for individuals to report any changes in mood or behavior to their healthcare provider while taking semaglutide. Finally, individuals with a history of gallbladder disease should use semaglutide with caution, as the medication may increase the risk of gallbladder problems.
Conclusion
Semaglutide injections can be an effective tool for weight loss when combined with diet and exercise. However, like any medication, semaglutide is not without its risks. Individuals considering this treatment should be aware of the potential side effects, drug interactions, and precautions before starting a semaglutide weight loss program. By working closely with their healthcare provider and following a personalized treatment plan, individuals can maximize the benefits of semaglutide while minimizing the risks.
In conclusion, the side effects of semaglutide injections for weight loss can vary from mild to severe. It is important for individuals to be aware of these potential risks and benefits before starting treatment. By understanding the common and rare side effects, as well as any drug interactions or precautions, individuals can make informed decisions about whether semaglutide is the right option for their weight loss journey.
Ultimately, the key to successful weight loss with semaglutide lies in open communication with a healthcare provider and diligent monitoring of any changes in symptoms or mood. With proper guidance and support, individuals can safely and effectively use semaglutide to achieve their weight loss goals.
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Anita Batra, MD, UCLA internal medicine physician, will discuss safe and effective strategies to lose weight and maintain weight
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Learn more about Dr. Anita Batra at https://uclahealth.org/AnitaBatra
Learn more at https://uclahealth.org
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Discover how to actually burn belly fat while sleeping in bed. Increasing your metabolism is possible for anyone regardless of your age and these tips will help boost your resting metabolic rate fast. Find out how to burn fat while sitting, sleeping, and resting.
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If you could burn more belly fat while sleeping in a bed it would make getting and staying lean significantly easier. As human beings, we spend about a third of our entire lives sleeping and even though it might sound too good to be true it's actually very possible to burn significantly more fat at rest than you're burning right now, That's why in today's video, I'm going to give you 8 proven ways that you can speed up fat burning while asleep.
First, although it won't be a huge increase one of the easiest ways to bump up your metabolism and burn more calories while sleeping is to have a Casein shake 30 minutes before bed.(1) Not only do studies show that casein is absorbed perfectly fine while you sleep but digesting it positively affects your resting metabolic rate throughout the night and even into the next morning (2).
Since Casein has a slow digestion rate it provides a continuous release of amino acids into your bloodstream while you sleep. This can help maintain muscle protein synthesis throughout the night as well, which prevents muscle breakdown and assists with muscle recovery. Another big benefit of, having casein before bed is that it can help you feel full for longer. This can help reduce nighttime snacking or overeating before going to sleep. As a trainer, it's very common to hear that many people struggle with late-night cravings and often mindlessly eat hundreds upon hundreds of calories right before bed. Having a filling casein shake or an alternative casein source like cottage cheese, or Greek yogurt, can effectively reduce appetite at night and can lower overall calorie intake. Taking casein before bed consistently over time has also been proven to benefit muscle strength and muscle growth. (3)
And that's actually one of the best ways to burn more belly and body fat while sleeping... by building more muscle. Muscle tissue is metabolically active and significantly more metabolically active than fat: This is because it requires energy to maintain itself. It also requires energy to carry out essential functions like repairing broken-down muscle fibers, supporting posture, and producing movement. This constant energy expenditure contributes to a higher resting metabolic rate, which means anytime that you're at rest regardless of whether you sleeping or relaxing on a couch you'll be burning more calories per minute, per hour, and per day, than you would if you had less muscle on your body. While fat tissue does of course cost some calories to maintain, it's less metabolically active compared to muscle. The other benefit of muscle tissue is that it's able to absorb and store glycogen which is the broken down and stored version of carbohydrates. Every time you lift heavy weights you'll deplete a lot of the stored glycogen in your liver and muscle tissue, allowing you to refill those glycogen stores again, without them spilling over into fat storage.
That actually brings us to the next thing you can do to burn more calories while sleeping lift heavy weights or perform other high-intensity workouts. This is due to something known as the Afterburn Effect, which is often used as a gimmicky term in fitness marketing campaigns to sell magic fat-burning pills, at-home exercise equipment, and training programs. But the afterburn effect is actually a real science-based phenomenon. The exact mechanism that supports a faster metabolism after high-intensity exercise is known as Excess Post-Exercise Oxygen consumption or in short Epoc. Essentially epoc leads to an increased amount of calories continuing to be burnt even after being done training. Your body will continue to burn calories at an elevated rate after a weightlifting session because it needs to repair and recover muscle tissue, replenish energy stores, and remove waste products.
This increased post-exercise calorie burn, can last anywhere from a few hours up to 2 whole days after performing your last set. How long it lasts for you depends on things like the intensity and duration of your weight training session. Higher intensities create a longer-lasting afterburn. It also depends on your fitness level, if you're well-conditioned epoc will actually be shorter-lived than if you're out of shape because your body will be able to bounce back faster. Lastly, compound movements like squats, deadlifts, and bench presses typically create a greater afterburn than isolation movements like bicep curls and tricep extensions. As an added benefit resistance training in general can improve insulin sensitivity, which helps your body better manage blood sugar levels, and can positively...
