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#diabetes #weightloss #diabetesdrug Research Reveals Method to Improve Diabetes and Weight-Loss Drug Performance According to new research from the University of Michigan, a network of proteins found in the central nervous system could be leveraged to enhance the effectiveness and minimize the side effects of popular diabetes and weight-loss medications. The study, published in the Journal of Clinical Investigation, focused on two proteins, melanocortin 3 and melanocortin 4, primarily located on the surface of neurons in the brain. These proteins play a central role in regulating feeding behavior and maintaining the body's energy balance.Melanocortin 3 and 4 influence everything from sensing long-term energy stores to processing gut signals about short-term satiety. GLP-1 agonists, such as semaglutides (e.g., Ozempic) and tirzepatides (e.g., Mounjaro), have gained attention for effectively treating type 2 diabetes, obesity, heart disease, and potentially addiction. These drugs mimic a natural hormone produced by the gut when full, signaling the brain to reduce feeding behavior. In the study, researchers tested the effects of several hormones that reduce food intake in the mouse models and discovered that modifying the melanocortin system made mice more responsive to GLP-1 drugs and other hormones influencing feeding behavior. Mice treated with a combination of a GLP-1 drug and an MC4R agonist or MC3R antagonist experienced up to five times more weight loss and reduced feeding compared to those receiving only GLP-1 drugs. The researchers also measured brain activity in areas associated with nausea from GLP-1 drugs and found no increased activation when these drugs were combined with alterations to the melanocortin system. However, priming melanocortin neurons significantly boosted GLP-1 drug activation in hypothalamic feeding centers. The findings suggested that combining GLP-1 drugs with an MC4R agonist could increase the drugs' effectiveness by up to fivefold without enhancing side effects. This approach could allow patients sensitive to side effects to take lower doses or improve outcomes in those unresponsive to current dosages. Further drug development and clinical testing are needed to advance this strategy. Although this research has only been conducted in mouse models, researchers remain optimistic that the results will translate effectively to humans. "The melanocortin system is highly conserved in humans. Everything we've observed in the mouse over the past decades studying these proteins has also been found in humans, so I suspect that these results would also be translatable to patients,” said Cone, director of the U-M Life Sciences Institute Check full updates on Medical Dialogues Also check out - Medical Dialogues Academy, a renowned academic wing of Medical Dialogues - India's premier health and news online portal, proudly presents this comprehensive course tailored for healthcare professionals eager to delve into the realm of medical journalism. 🔗 Enroll Today: https://academy.medicaldialogues.in/courses/certificate-course-in-medical-journalism/ 📚 Explore More With Us: 📌 Medical Content Writing: https://academy.medicaldialogues.in/courses/medical-content-writing/ 📌 Certificate Course in Pharmaceutical Medico-Marketing: https://academy.medicaldialogues.in/courses/certificate-course-in-pharmaceutical-medico-marketing/ Join us on this enlightening journey and become a part of a community pushing the boundaries of healthcare communication and reporting. Get the latest medical and health news at medicaldialogues.in Follow us on Twitter: https://twitter.com/medicaldialogs Facebook: https://www.facebook.com/medicaldialogues/ Instagram: https://www.instagram.com/medicaldialogues LinkedIn: https://www.linkedin.com/company/medical-dialogues Website: https://medicaldialogues.in/

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Are you on the lookout for a convenient and delicious way to support your ketogenic lifestyle? ACV Keto Gummies by Simpli Health may be just what you need. These gummies claim to provide a potent combination of apple cider vinegar (ACV) and other key ingredients to help you maintain ketosis and support your weight loss goals. But do they live up to their promises? In this article, we will evaluate the claims and effectiveness of ACV Keto Gummies from Simpli Health.

Understanding Ketosis and Apple Cider Vinegar

Before diving into the specifics of ACV Keto Gummies, it’s important to have a basic understanding of ketosis and apple cider vinegar. Ketosis is a metabolic state in which your body burns fat for energy instead of carbohydrates. This process can lead to weight loss and other health benefits. Apple cider vinegar has gained popularity for its potential to aid in weight loss, improve digestion, and regulate blood sugar levels.

ACV Keto Gummies by Simpli Health combine the benefits of apple cider vinegar with other ingredients like exogenous ketones and MCT oil to create a convenient and tasty supplement for those following a ketogenic diet. These gummies claim to help you stay in ketosis, boost your energy levels, and support your overall health and wellness.

But do ACV Keto Gummies really work? Let’s take a closer look at their claims and effectiveness to determine if they are worth adding to your keto routine.

Evaluating the Claims of ACV Keto Gummies

Claim 1: Supports Ketosis – One of the primary claims of ACV Keto Gummies is that they can help support ketosis, the metabolic state essential for fat burning. The combination of apple cider vinegar and exogenous ketones in these gummies is said to aid in achieving and maintaining ketosis.

Claim 2: Boosts Energy Levels – In addition to supporting ketosis, ACV Keto Gummies are advertised to provide a quick and convenient source of energy. MCT oil, a key ingredient in these gummies, is known for its ability to boost energy levels and mental clarity.

Claim 3: Aids in Weight Loss – Many people turn to apple cider vinegar for its potential weight loss benefits. ACV Keto Gummies claim to harness the power of ACV in a delicious gummy form to help you reach your weight loss goals more effectively.

The Effectiveness of ACV Keto Gummies

Effectiveness 1: Ketosis Support – While the ingredients in ACV Keto Gummies have been shown to support ketosis, individual results may vary. It’s essential to combine these gummies with a well-rounded ketogenic diet and regular exercise for optimal results.

Effectiveness 2: Energy Boost – Many users report feeling a noticeable increase in energy levels after taking ACV Keto Gummies. The combination of apple cider vinegar, exogenous ketones, and MCT oil provides a quick and sustainable source of energy.

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Effectiveness 3: Weight Loss Aid – When used as part of a healthy lifestyle, ACV Keto Gummies can aid in weight loss efforts. The appetite-suppressing effects of apple cider vinegar, combined with the metabolism-boosting properties of exogenous ketones, may help support your weight loss journey.

Should You Try ACV Keto Gummies?

After evaluating the claims and effectiveness of ACV Keto Gummies from Simpli Health, it’s clear that these gummies can be a beneficial addition to your ketogenic lifestyle. Whether you’re looking to support ketosis, boost your energy levels, or aid in weight loss, ACV Keto Gummies offer a convenient and tasty solution. Unlock Weight Loss By Reducing Brain Inflammation

However, it’s essential to remember that supplements are not a magic solution and should be used in conjunction with a healthy diet and regular exercise. If you’re considering trying ACV Keto Gummies, consult with your healthcare provider to ensure they are a safe and suitable option for you.

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Doctors break down what cholesterol really is, why it matters, and how to reduce it safely and effectively. 🫀 You’ll learn: – The difference between HDL, LDL, and triglycerides 🧪 – What foods raise — and lower — your cholesterol levels 🥑 – Lifestyle changes that make the biggest impact 🏃‍♂️ – When cholesterol becomes a serious risk for heart disease ⚠️ 📩 contact us: [email protected] #cholesterol #talkingwithdocs #hearthealth #doctorapproved #sciencebasedhealth #cholesteroldiet #bloodpressure #nutritiontips #healthyliving #stroke #heartdisease #inflammation #healthfacts

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