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My guest is Dr. Chris Palmer, M.D., a board-certified psychiatrist and professor at Harvard Medical School. He explains how specific nutrition, exercise, supplement-based, and other factors can improve mitochondrial health and thereby provide relief from adult and childhood ADHD, bipolar disorder, schizophrenia, and symptoms of autism. We discuss mitochondrial biology, whether vaccines can impact inflammation and mitochondrial health, and the potential ramifications. We also review creatine, methylene blue, and urolithin A, as well as the role of B vitamins and iron in treating depression. By the end of this episode, you will understand the powerful link between metabolic health and mental health, and the lifestyle, dietary, and other factors you can leverage to help overcome common mental health challenges and disorders. Read the episode show notes: https://go.hubermanlab.com/HohfgwG *Thank you to our sponsors* AG1: https://drinkag1.com/huberman Our Place: https://fromourplace.com/huberman LMNT: https://drinklmnt.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman *Dr. Chris Palmer* Brain Energy (book): https://amzn.to/4j4pus2 Personal website: https://www.chrispalmermd.com Harvard academic profile: https://cmecatalog.hms.harvard.edu/faculty-staff/christopher-palmer Brain Energy Fund: https://www.gofundme.com/f/the-brain-energy-fund Newsletter Signup: https://newsletter.brainenergy.com Facebook: https://www.facebook.com/ChrisPalmerMD X: https://x.com/ChrisPalmerMD Instagram: https://www.instagram.com/chrispalmermd YouTube: https://www.youtube.com/@ChrisPalmerMD Threads: https://www.threads.net/@chrispalmermd LinkedIn: https://www.linkedin.com/in/christopher-palmer-01713032 *Timestamps* 00:00:00 Dr. Chris Palmer 00:02:15 Integrating Metabolic, Mental & Physical Health; Childhood Trauma & Risk 00:10:46 Sponsors: Our Place & LMNT 00:13:44 Depression Causes, Molecule Model?, Neuroplasticity?; Metabolism 00:22:20 Mitochondrial Functions, Stress Response, Mental Health 00:31:09 Sponsors: AG1 & Eight Sleep 00:33:59 Mitochondrial Health & 6 Pillars of Lifestyle Medicine 00:39:38 Stimulants, Mitochondria, Dopamine; Alcohol 00:45:47 Nicotine; Substance Use, Metabolic Health & Disease 00:52:23 Children, Energy & Metabolic Function; Diseases of Aging & Mental Disorders 00:59:18 Sponsor: Function 01:01:06 Diet & Metabolism; Ultra-Processed Foods, Additives, GRAS 01:09:30 Rebellious Spirit, Ultra-Processed Foods & Food Industry Funding 01:19:14 Ketogenic Diet, Epilepsy, Schizophrenia, Bipolar 01:22:52 Ketogenic Diet, Fasting & Mitochondria; Gut Microbiome, Brain Metabolism 01:30:06 Low-Fat Diets; Tool: Occasional Fasts; Ketogenic Diet; Intermittent Fasting 01:38:40 Nutrition Research, Food Industry Lobbyists; Ultra-Processed Foods, Addiction 01:46:55 Creatine & Mitochondrial Health 01:52:34 Methylene Blue & Mitochondria; Serotonin Syndrome 02:02:58 Urolithin A, Mitochondria Function; Supplements & Appropriate Use 02:11:14 Vitamin Deficiencies, Iron Deficiency 02:16:06 Vitamin B12 & Folate Deficiency, Autoimmune Disorders 02:24:48 Mental Illness & Root Causes 02:29:02 Vaccines, Inflammation, Mitochondria, Autism 02:39:17 Neurodevelopmental Disorder Onset & Follow-Up 02:45:31 Vaccines, Autism, Future Research; Mother Obesity & Diabetes 02:51:23 Father Obesity & Autism; Poor Metabolic Health, Blood Biomarkers 02:56:44 Assessing Metabolic Health & Biomarkers; National Institutes of Health (NIH) 03:02:59 Future Directions, Bridging Mental & Physical Health 03:09:27 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter #HubermanLab #Science #Health #MentalHealth #Nutrition Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

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Weight loss is a common goal for many people who struggle with obesity or other health conditions. While diet and exercise are often the first lines of defense in achieving weight loss, some individuals may need additional assistance in reaching their goals. One such tool that has gained attention in recent years is the drug semaglutide. Originally developed to treat type 2 diabetes, semaglutide has shown promising results in aiding weight loss in clinical trials. This article will explore the role of semaglutide as a weight loss drug, its mechanism of action, potential benefits and side effects, and how it compares to other weight loss medications.

Mechanism of Action

Semaglutide is a glucagon-like peptide-1 receptor agonist, which means it mimics the action of the naturally occurring hormone GLP-1 in the body. GLP-1 is released from the gut in response to food intake and stimulates insulin release from the pancreas, leading to decreased blood glucose levels. In addition to its effects on blood sugar regulation, GLP-1 also plays a role in appetite control and satiety. By activating the GLP-1 receptor, semaglutide can help reduce appetite and food intake, leading to weight loss.Unraveling The Science Why Does Semaglutide Cause Weight Loss





Furthermore, semaglutide has been shown to slow gastric emptying, which can contribute to feelings of fullness and reduce the urge to eat. This combination of effects on appetite regulation and gastric emptying makes semaglutide a promising option for individuals struggling with weight loss.

Unlike some weight loss medications that target the central nervous system and may have systemic side effects, semaglutide works through the gut-brain axis to regulate appetite and food intake. This targeted approach may lead to fewer side effects and better tolerability compared to other weight loss drugs.

Clinical Trials and Efficacy

Several clinical trials have evaluated the efficacy of semaglutide for weight loss in overweight and obese individuals. One of the largest trials, known as the STEP program, included over 4,500 participants and compared different doses of semaglutide to placebo. The results showed that participants who received semaglutide lost significantly more weight than those in the placebo group, with some individuals achieving weight loss of 15% or more.

In addition to weight loss, participants in the semaglutide group also experienced improvements in other metabolic parameters, such as blood pressure, cholesterol levels, and glycemic control. These findings highlight the potential benefits of semaglutide not only for weight management but also for overall health and well-being.

Another important aspect of semaglutide therapy is its potential to help individuals maintain weight loss over the long term. Many people struggle to keep off weight they have lost through diet and exercise alone, but semaglutide may offer a solution by providing ongoing support for appetite control and satiety.

Side Effects and Safety Profile

Like any medication, semaglutide is not without risks. Common side effects of semaglutide include gastrointestinal symptoms such as nausea, vomiting, and diarrhea. These side effects may occur more frequently when starting the medication or with higher doses, but they often improve over time as the body adjusts to the drug.

In rare cases, semaglutide may also lead to more serious side effects, such as pancreatitis or gallbladder disease. Patients should be monitored for signs and symptoms of these conditions while taking semaglutide, and the medication should be used with caution in individuals with a history of these diseases.

Overall, the safety profile of semaglutide appears favorable, especially when compared to some other weight loss medications that have been associated with more serious side effects. However, as with any medication, patients should discuss the risks and benefits with their healthcare provider before starting treatment with semaglutide.

Comparison to Other Weight Loss Medications

When compared to other weight loss medications on the market, semaglutide stands out for its efficacy and safety profile. While some medications work by suppressing appetite through effects on the central nervous system, semaglutide targets the gut-brain axis to regulate appetite and food intake more naturally.

In addition, semaglutide has been shown to produce greater weight loss than other medications, with some individuals achieving significant reductions in body weight. This may make semaglutide a preferred option for individuals with obesity or those who have not achieved success with other weight loss strategies.

Furthermore, the long-term benefits of semaglutide therapy, including improved metabolic parameters and weight maintenance, set it apart from other medications that may only provide short-term weight loss. For individuals looking for a comprehensive approach to weight management, semaglutide may offer a promising solution.

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Ketorganix Acv What You Should Know

The popularity of the ketogenic diet has been on the rise in recent years, with many people turning to this low-carb, high-fat diet to help them shed unwanted pounds and improve their overall health. One of the challenges of following a keto diet is finding tasty and convenient snacks that are low in carbs and high in fat. This is where keto gummies come in – a delicious and convenient way to enjoy a sweet treat while staying in ketosis.

Keto Gummies Reviews: Comprehensive Reviews of Popular Keto Gummy Products

If you’re looking to add some variety to your keto snack arsenal, you may be considering trying out some keto gummies. But with so many options on the market, it can be overwhelming to choose the right product for you. That’s where we come in – we’ve done the research for you and compiled comprehensive reviews of some of the most popular keto gummy products available.

Best Overall Keto Gummy

Our top pick for the best overall keto gummy is XYZ Keto Gummies. These gummies are not only delicious but also packed with high-quality ingredients that are keto-friendly. Made with no added sugar and only natural flavors, XYZ Keto Gummies are a guilt-free way to satisfy your sweet tooth while staying on track with your keto diet. Plus, they come in a variety of flavors that are sure to please your taste buds.

Best Budget-Friendly Keto Gummy

If you’re looking for a more affordable option, ABC Keto Gummies are a great choice. These gummies are wallet-friendly without compromising on taste or quality. Made with clean ingredients and zero net carbs, ABC Keto Gummies are a great option for those looking to stick to their keto diet without breaking the bank.

Best Vegan Keto Gummy

For those following a vegan keto diet, DEF Keto Gummies are the perfect choice. These gummies are made with plant-based ingredients and are free from any animal products, making them suitable for vegans. Despite being vegan, DEF Keto Gummies are full of flavor and have a satisfying chewy texture that you’re sure to love.

Best Sugar-Free Keto Gummy

If you’re watching your sugar intake, GHI Keto Gummies are a great option. These gummies are sweetened with natural sugar substitutes like stevia and erythritol, so you can enjoy a sweet treat without spiking your blood sugar levels. With zero added sugar and only 2g of net carbs per serving, GHI Keto Gummies are a guilt-free way to indulge in a tasty snack.

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Best Keto Gummy for Weight Loss

If you’re looking to support your weight loss goals while on the keto diet, JKL Keto Gummies are a great choice. These gummies are formulated with ingredients that may help boost metabolism and promote fat burning, making them a great addition to your weight loss journey. With a delicious taste and convenient packaging, JKL Keto Gummies are the perfect snack to help you stay on track with your goals.

Whether you’re looking for a tasty treat to satisfy your sweet tooth or a convenient snack to keep you on track with your keto diet, there’s a keto gummy out there for you. With our comprehensive reviews of popular keto gummy products, you can make an informed decision and find the perfect gummy to fit your needs.

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A look at the new Lean Mass Hyper-responder report by Feldman, Budoff, and Norwitz leading people to claim that high LDL doesn't cause heart disease. Let's look at a whistleblower's claims and over 20 studies for an answer. - Links and Sources - Support Me Here: https://www.patreon.com/micthevegan My Cookbook: https://micthevegan.com/product/mics-whole-vegan-cookbook/ https://www.tiktok.com/@micthevegan https://www.facebook.com/micthevegan https://www.instagram.com/micthevegan - @micthevegan Vegan Bootcamp: https://vbcamp.org/Micthevegan TIY Tiny House Channel: https://www.youtube.com/channel/UCYhthOBh4_459pAge62at8g My New Newsletter Sign-Up: https://mailchi.mp/2785ad113ff7/micthevegan-emails Miami Heart Study: https://www.sciencedirect.com/science/article/pii/S266666772100057X Sitting and Plaque Studies: https://journals.lww.com/jcma/fulltext/2022/01000/prolonged_sitting_time_links_to_subclinical.8.aspx https://www.sciencedirect.com/science/article/pii/S0735109715614462?via%3Dihub BMI and Plaque: https://journals.sagepub.com/doi/10.1177/1479164119825761 Dr Spencer Nadolsky Twitter Thread: https://twitter.com/DrNadolsky/status/1733541113904910667 Carnivore Dieter 90th and 97th Percentile Clogging Case Study: https://www.atherosclerosis-journal.com/article/S0021-9150(22)00975-3/fulltext Standard FH Timeline of CAD Development and Risk: https://www.mp.pl/paim/issue/article/16248/ FH 3x Mortality Risk: https://www.frontiersin.org/articles/10.3389/fcvm.2022.860196/full Severe FH Event Risk: https://www.nature.com/articles/s41598-023-47147-z Severe FH Plaque Reversal: https://www.atherosclerosis-journal.com/action/showPdf?pii=S0021-9150%2821%2900206-9 Genetically Higher HDL Doesn't Lower Risk: https://pubmed.ncbi.nlm.nih.gov/22607825/ Triglycerides 50 vs 100 Risk: https://www.researchgate.net/publication/8152665_Addressing_Cardiovascular_Disease_in_Women_Focus_on_Dyslipidemia Heme Iron, Stroke, and Oxidative Stress: https://www.ahajournals.org/doi/10.1161/strokeaha.112.679662 Heterocyclic Amines and Oxidative Stress: https://pubmed.ncbi.nlm.nih.gov/25812604/ Trans Fat Oxidized LDL Study: https://www.sciencedirect.com/science/article/pii/S0914508717300151 Dietary Oxidized Cholesterol Enters Blood: https://www.sciencedirect.com/science/article/pii/S0022227520311603 Dietary Oxidized Cholesterol Increases Lesions in Mice: https://www.ahajournals.org/doi/full/10.1161/01.ATV.18.6.977 Antioxidants Buffer LDL Oxidation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211048/pdf/antioxidants-07-00133.pdf Hyperlipidemia Most Correlated with Oxidized LDL over Diabetes: https://www.ahajournals.org/doi/10.1161/01.atv.21.5.844 LMHR Lipid Energy Model: https://www.mdpi.com/2218-1989/12/5/460 Letter to Editor Warning about LMHR Narrative: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154254/pdf/nzac042.pdf Intro/Outro Song: Sedução Momentânea by Roulet: http://freemusicarchive.org/music/Roulet/Beats_dAmor/Roulet_-_Beats_dAmor_-_07_Seduo_Momentnea #LMHR #Keto #heartdisease

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