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Weight Loss Effectiveness (Annual Averages): Rybelsus: ~8 percent Ozempic: ~13 percent Wegovy: ~16 percent Tirzepatide (Zepbound): ~22 percent — most effective so far. 2. Mechanism of Action: Ozempic (Semaglutide) mimics GLP-1, which: Suppresses appetite Slows gastric emptying Increases insulin Decreases glucagon This leads to lower blood sugar and reduced food intake. 3. Not FDA-Approved for Weight Loss: Ozempic is only approved for Type 2 diabetes, while Wegovy (same molecule, higher dose) is approved for weight loss. 4. Risk of Vision Loss (New Concern): Rare cases of non-arteritic anterior ischemic optic neuropathy reported. Normally: ~10 per 100,000 people With Ozempic: ~30 per 100,000 (300 percent increase) Still rare but permanent if it occurs. 5. Most Common Side Effects (~25 percent): Nausea Vomiting Diarrhea Constipation Occur in about 1 in 4 users. 6. Gallbladder Issues (2–3 percent): Rapid weight loss can lead to: Gallstones Gallbladder inflammation 7. Pancreatitis (Rare but Serious): Less than 1 percent, but can be life-threatening. Symptoms include severe abdominal pain and vomiting. 8. Thyroid Cancer Warning: Based on mouse studies, not humans. However, still contraindicated in people with MEN2 or family history of MTC. MEN2 patients almost always develop MTC by age 40. 9. Patent Timeline for Semaglutide: Core patent expires in 2026 → generics possible by 2027 Secondary patents (like pen design) expire by 2033 → price drop expected 10. Price Differences: USA: ~$1,000/month without insurance Georgia (country): ~$500 for 3 months Disclaimer: This information is provided for general knowledge and educational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always consult with your doctor for any questions or concerns you may have about your health.
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