Even as we prioritize natural interventions in functional medicine, GLP-1 agonist drugs such as Wegovy and Ozempic offer sometimes life-changing support for those who have long struggled with resistant overweight/obesity and high blood sugar. However, there are side effects, including the risk of substantial muscle loss and sagging, aged skin ("Ozempic face" as it's indelicately known). It's a concern that hits home for me, considering the pivotal role we know that muscle plays in overall health and longevity.
In this New Frontiers podcast episode I welcome back Dr. Anurag Singh to unravel the complexities of these issues. We explore the interplay between metabolic health and muscle preservation, touching on everything from the mechanisms of GLP-1 agonists and their long-term effects on aging and sarcopenia, to the promising potential of dietary and lifestyle interventions to counteract negative effects. We consider the potential for one of my all-time fave postbiotic epinutrients - Urolithin A - to assist by supporting mitochondrial health and preserving/enhancing muscle quality. This timely conversation is one you won't want to miss. Tune in and please leave us a review wherever you listen to New Frontiers. – DrKF
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.
*Guest information*
Anurag Singh, MD, PhD
Chief Medical Officer at Timeline
*Thank you to our sponsor*
Timeline: https://tinyurl.com/4npjcvjf
Mitopure: https://tinyurl.com/ypfjws2e
Research from Timeline: https://tinyurl.com/53p6yjc9
[email protected]
*Timeline Discount for New Frontiers Listeners*
Timeline is offering Dr. Fitzgerald’s readers a 10% discount on Timeline products. Head on over to https://tinyurl.com/ypfjws2e and use the code KARA10 at the checkout.
*Show Notes*
Study: Once-Weekly Semaglutide in Adults with Overweight or Obesity: https://tinyurl.com/y3c2ypkw
Pre-clinical trial (Recruiting): Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55= Years Old: A Randomized Triple-Masked Controlled Clinical Trial - https://https://tinyurl.com/bdzfccr8
Study: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults - https://tinyurl.com/2p9pjpxc
Study: Antidiabetic Effect of Urolithin A in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Glucose Intolerance - https://tinyurl.com/2jkhmu9w
Study: Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis - https://tinyurl.com/mvrjxxsm
Study: Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial - https://tinyurl.com/fscfdd85
Study: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans - https://tinyurl.com/mr2hd4ms
Study: Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population - https://tinyurl.com/e6npdvyp
Preprint article: Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials - https://tinyurl.com/2m2nzd56
Preclinical trial: Effects of Mitopure (Urolithin A) on Skeletal Muscle Function, Iron Metabolism and Endurance Performance (ENDURO) - https://tinyurl.com/nhkw2pvc
Study: The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome - PubMed (nih.gov) - https://tinyurl.com/mrkk33e5
Study: Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice | PLOS Biology - https://tinyurl.com/3s38vtau
Study: Urolithin A production drives the effects of pomegranate on the gut microbial metabolism of bile acids and cholesterol in mild dyslipidaemic overweight and obese individuals - PubMed (nih.gov) - https://tinyurl.com/wdzk3tx7
*DrKF Resources*
FxMed Podcast: Beyond Mitochondrial Health: Can Urolithin A Slow Down Aging? - https://tinyurl.com/svzahswu
DrKF Blog: Beyond Beauty: Targeting Skin Longevity with Urolithin A - https://tinyurl.com/5n6zfu9s
DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb
Bio Age Lab Test: https://tinyurl.com/b7bjmfj9
Bio Age Self Assessment Quiz: https://tinyurl.com/4z8f7ucc
Younger You Group Program: https://tinyurl.com/4hvusavw
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw
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For personal sports nutrition and weight loss plans, please contact me directly via message, email [email protected] , or Instagram Ingrid Kick.
The number of calories you burn will vary from person to person depending on your body composition, workout intensity and also fitness level but this might serve as a guideline.
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D I S C L A I M E R
This is my own personal workout and may not be suited for you. It is strongly recommended that you consult with your physician before beginning any exercise program. By engaging in this exercise or exercise program, you agree that you do so at your own risk.
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I have lost 123 pounds from my highest weight with the help of both weight loss surgery (gastric sleeve) and GLP1 (semaglutide). Ive gotten a lot of questions about why am I taking a GLP1 after VSG and so in this video, I am going to let you know why.
This is the scale and measuring tape that I use and it comes with the free app:
Weight Scale with App - https://amzn.to/3UoqVbO
Measuring Tape - https://amzn.to/42oSvHU
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T I M E C O D E S
0:00 - Intro
1:15 - Not Medical Advice
1:33 - Stalling after Weight Loss Surgery
2:28 - Honeymoon stage after Weight Loss Surgery
3:03 - Weight Loss Medication
3:52 - Food Noise
5:50 - GLP1 after Weight Loss Surgery
6:21 - What is GLP1
6:41 - Compound GLP1 Medications
7:37 - Starting Semaglutide
8:34 - Why am I taking GLP1 after WLS
9:18 - My Weight Goals
11:05 - How long am I going to be on Semaglutide
11:51 - Want to add a GLP1 to your journey
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B U S I N E S S I N Q U I R I E S
[email protected]
M Y F A V O R I T E L I N K S
https://linktr.ee/Janeeleesanders
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F O L L O W M E O N M Y S O C I A L S
Instagram: https://instagram.com/janeeleesanders
TikTok: https://tiktok.com/@janeeleesanders
C H E C K O U T M Y W E B S I T E
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M U S I C
Music by STUDIO BEYOND - Love Week - https://thmatc.co/?l=02039EEB
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E Q U I P M E N T U S E D
Camera: Sony ZV-1 - https://amzn.to/328LujJ
Editing: Final Cut Pro
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The use of Keto diet plans has become increasingly popular in recent years as people seek effective ways to lose weight and improve their overall health. One product that has gained attention in the weight loss industry is Power Keto, which claims to offer a sustainable weight loss solution. The product was even featured on the popular television show Shark Tank, which sparked curiosity among viewers about its effectiveness.
What is Power Keto?
Power Keto is a dietary supplement that is designed to help individuals achieve ketosis, a metabolic state where the body burns fat for fuel instead of carbohydrates. The supplement contains a blend of natural ingredients, including BHB (Beta-Hydroxybutyrate) salts, that are supposed to help kickstart the body into ketosis and promote weight loss.
When the body is in ketosis, it is believed to be more efficient at burning fat for energy, which can lead to weight loss. This is why many people turn to Keto diet plans and supplements like Power Keto to help them reach their weight loss goals.
Does Power Keto Really Work?
While Power Keto and similar supplements may help some individuals reach ketosis faster, it is important to note that there is no magic solution when it comes to weight loss. The effectiveness of Power Keto will vary from person to person, depending on factors such as diet, exercise, and overall health.
It is always recommended to consult with a healthcare professional before starting any new dietary supplement or weight loss program. This will ensure that you are approaching your weight loss goals in a safe and healthy manner.
Are There any Side Effects?
As with any dietary supplement, there may be potential side effects when taking Power Keto. Some common side effects reported by users include digestive issues, headaches, and difficulty sleeping. It is important to listen to your body and discontinue use if you experience any adverse reactions.
If you have any underlying health conditions or are pregnant or breastfeeding, it is especially important to consult with a healthcare professional before taking Power Keto or any other dietary supplement. Your doctor can provide personalized guidance based on your individual health needs.
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Is Power Keto a Sustainable Weight Loss Solution?
While Power Keto may offer some benefits in terms of assisting with ketosis and promoting weight loss, it is not a long-term solution on its own. Sustainable weight loss requires a combination of healthy eating habits, regular exercise, and lifestyle changes.
Using Power Keto as a supplement to support your weight loss goals can be effective, but it should not be relied upon as the sole method for achieving and maintaining a healthy weight. Remember that consistency and dedication to a healthy lifestyle are key components of sustainable weight loss.
Final Thoughts on Power Keto
Power Keto may provide some assistance in reaching your weight loss goals, but it is not a miracle solution. As with any dietary supplement, it is important to approach it with caution and consider the potential risks and benefits. Remember that sustainable weight loss is a journey that requires dedication, patience, and a commitment to healthy habits.
Ultimately, the decision to try Power Keto or any other weight loss supplement is a personal one. It is recommended to do thorough research, consult with healthcare professionals, and listen to your body to make informed decisions about your health and wellness goals.
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