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With millions of people now taking GLP-1 agonists like Ozempic and Wegovy, I was curious to learn if there are known genetic mutations that predispose people to have serious side effects from these medications. So exploring the pharmacogenomic aspects of Ozempic and Wegovy. To answer these questions Dr. Josiah Allen is joining the show. Josiah Allen, PharmD, has spent over 15 years in the field of pharmacogenomics, beginning at the Mayo Clinic where he helped develop the GeneSight test. As a founding employee and the first medical science liaison at Assurex Health, he helped GeneSight become one of the fastest growing molecular diagnostic tests in history. He later served as director of medical affairs at OneOme and now works at St. Elizabeth Healthcare in Edgewood, KY, as a precision medicine pharmacist and PGY2 Clinical Pharmacogenomics pharmacy residency program director. He earned his bachelor's degree in psychology from Wheaton College and his Doctor of Pharmacy degree from the University of Minnesota. Topics Covered: The basics of pharmacogenomics and its role in personalized medicine. How genetic mutations, like those in the RET gene, influence medication risks. The pharmacogenomics of GLP-1 agonists (like Ozempic and Wegovy), including their contraindications for patients with RET mutations. Insights into the overlap between ACMG secondary findings and pharmacogenomic implications. Case studies illustrating the real-world impact of pharmacogenomics. Key Takeaways: GLP-1 agonists, such as Ozempic and Wegovy, carry a black box warning due to an association with thyroid cancer, particularly in individuals with RET gene mutations. Over one-third of the ACMG secondary findings genes have pharmacogenomic implications, emphasizing the need for clinicians to integrate genetic insights into prescribing practices. Pharmacists and geneticists need closer collaboration to bridge the gap between clinical genomics and pharmacogenomics for safer medication use. Get ready, genetic nerds—another brand-new episode of DNA Today drops next Friday! You can always count on us to deliver fresh content every Friday. While you wait, why not dive into our library of over 300 episodes? Binge them all on Apple Podcasts, Spotify, our website, or wherever you love to listen—just search “DNA Today.” DNA Today is hosted and produced by Kira Dineen, MS, LCGC, CG(ASCP)CM . Our Video Lead is Amanda Andreoli. Our Social Media Lead is Kajal Patel. Our Outreach Intern is Liv Davidson. And our logo Graphic Designer is Ashlyn Enokian, MS, CGC. See what else we are up to on Instagram, X (Twitter), BluSky, Threads, LinkedIn, Facebook, YouTube all at DNATodayPodcast. Our website is DNAToday.com. Questions/inquiries can be sent to [email protected].

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How did Christina Aguilera Lose Weight? DIET & EXERCISE My Site: https://www.supplementsuperhero.com/how-did-christina-aguilera-lose-weight-diet-exercise-secrets-revealed FREE Fat Burner: supplementsuperhero.com/burn (affiliate link) What's up Heroes!? In this video I go over how Christina Aguilera was able to lose weight successfully over the course of a couple years. The 36 year-old stands 5'2” and weighs approximately 110 lbs. Over the years leading up to 2014, Christina Aguilera underwent a good amount of criticism in regards to her weight fluctuations. There were also rumors going around about how she underwent liposuction. It turns out that those rumors were false. I don't know the specific time frame, but in the year or 2 leading into 2014, Christina lost an incredible 50 POUNDS! It was not liposuction. It was through consistent hard work and developing good habits. Christina Aguilera Weight Loss Tips: 1. Eat a well-balanced diet 2. Yoga 3. Workout regularly with a personal trainer 4. Suggested foods: blueberries, healthy fats like avocado, chicken breast, salads, shrimp cocktail 5. She cut back on alcohol but still enjoys an occasional glass of wine 6. She has 2 children, so taking care of her kids and keeping up with them keeps her active She is also encourages people to simply embrace their body no matter what their shape or size is. She wishes that more women would be proud of their bodies and not diss other women for being proud of theirs. Supp. It. Up. -David Hoang Other videos on my channel: Paleo vs Keto Diet https://youtu.be/QiJLiw8SKLQ 5:2 Diet Review https://youtu.be/0f58Pp0nTq8 How to Reduce Thigh Fat WITHOUT Exercise! https://youtu.be/thOZwNSnHsk 3 SIMPLE Thigh Fat Burning Exercises at Home https://youtu.be/RnRpED63mx8 How to Lose Thigh Fat: 10 Tips You MUST Know!! https://youtu.be/Lun41e3dj8Y How to Lose Thigh Fat Pt 2: 6 EXTRA Tips You SHOULD Know! https://youtu.be/eYWbpbkoUzI Matcha Green Tea Powder Review https://youtu.be/rU7RVWfGoY4 Lose Thigh Fat While Being Lazy: 6 EASY Tricks https://youtu.be/asFSsI-j7D0 How to Decrease Thigh Fat as a Busy College Student https://youtu.be/gBGx9eR36_E How to get Rid of Thigh Fat FAST at the OFFICE? 8 EASY Tips https://youtu.be/_iAHE0WaKyU It Works Fat Fighters Review: Personal Testimonial https://youtu.be/R2ii_doZSaw Ketogenic Diet Review: https://youtu.be/qS8lAfEG7fE How Keto Coffee Helps to Reduce Thigh Fat https://youtu.be/jsWQwagNt04 MSM-related videos: https://youtu.be/IENPean1rys https://youtu.be/w9Gl2ecYyAE Note: The content I produce on both my site and this YouTube channel are based on my own personal experiences and research. My statements have not been evaluated by the Food and Drug Administration. None of the products I review and talk about are intended to diagnose, treat, cure, or prevent any disease.

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Ack! Everything's changing! In this week’s GLP-1 weight loss journey update, everything changed when I meant to stay the course. I'm sharing the unexpected twists I faced while navigating menopause, weight loss, and GLP-1 medications like semaglutide and my new prescription, tirzepatide (Zepbound). 👉 In this video, I talk about: * Why I'm switching from compounded semaglutide to Zepbound * The surprising results from my DEXA scan * How I'm adjusting my protein intake, calories, and strength training * Real talk about fat loss vs. muscle loss and how I’m course-correcting Whether you're on Wegovy, Mounjaro, Tirzepatide, Zepbound, or just curious about GLP-1 medications, this video offers real-life insights from a postmenopausal woman managing hormonal weight gain, emotional wellness, and sustainable health changes. 🔔 Subscribe for weekly updates on my wellness journey and helpful tools for thriving through midlife. #menopauseweightloss #weightloss #Wegovy #Semaglutide #Mounjaro #Tirzepatide #weightlossjourney #GLP1WeightLoss #MenopauseWeightLoss #TirzepatideJourney #Zepbound #CompoundedSemaglutide #WeightLossOver50 #HormonesAndHealth #MenopauseFitness

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