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All you need to know about the science of gut health and it's relationship with bloating, digestion, fat loss, mental health!
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Some of my favourite papers/articles/sources:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433529/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264926/
https://www.cell.com/cell-reports/fulltext/S2211-1247(17)30119-5
https://www.nature.com/news/gut-microbe-swap-helps-mice-shed-weight-1.12688
https://www.sciencedaily.com/releases/2018/09/180906141640.htm
https://www.cell.com/cell/fulltext/S0092-8674(18)31102-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867418311024%3Fshowall%3Dtrue
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829625/
http://www.jneuropsychiatry.org/peer-review/efficacy-of-probiotics-on-anxiety-a-metaanalysis-of-randomized-controlled-trials.pdf
https://www.monashfodmap.com/ibs-central/i-have-ibs/starting-the-low-fodmap-diet/
https://gut.bmj.com/content/67/9/1716
http://commonfund.nih.gov/hmp/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385025/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881382/
https://www.sciencedaily.com/releases/2014/03/140310090921.htm
https://www.bmj.com/content/361/bmj.k2179
https://www.nature.com/articles/s41598-017-05772-5
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045147/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064361/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933040/
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Kevin R. Gendreau, MD, is a board-certified obesity medicine physician, author, and advocate for metabolic health based in Fall River, Massachusetts. With a personal journey of losing 125 pounds and reversing type II diabetes through lifestyle modifications, Dr. Gendreau brings a unique and compassionate perspective to his work.
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Semaglutide is a medication that has been gaining attention in the medical field for its potential to aid in weight loss. Originally developed for the treatment of type 2 diabetes, semaglutide has shown promising results in clinical trials for weight management. As obesity rates continue to rise globally, the search for effective weight loss solutions has become more pressing. In this article, we will evaluate the pros and cons of semaglutide for weight loss.
Effectiveness of Semaglutide for Weight Loss
Semaglutide works by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1), which regulates blood sugar levels and appetite. By activating GLP-1 receptors in the brain, semaglutide can help reduce food cravings and increase feelings of fullness, leading to a decrease in caloric intake. Clinical trials have shown that patients who took semaglutide experienced significant weight loss compared to those who took a placebo.
Furthermore, semaglutide has been found to be more effective than other weight loss medications currently on the market. In one study, participants who took semaglutide lost an average of 15% of their body weight, compared to just 2-4% with other medications. This makes semaglutide a promising option for individuals struggling with obesity and related health conditions.
In addition to its weight loss benefits, semaglutide has also been shown to improve overall metabolic health. By improving insulin sensitivity and reducing inflammation, semaglutide may help reduce the risk of developing type 2 diabetes and cardiovascular disease in overweight individuals.
Potential Side Effects of Semaglutide
Like any medication, semaglutide is not without its side effects. Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are typically mild and tend to decrease over time as the body adjusts to the medication. However, some individuals may experience more severe side effects, such as pancreatitis or gallbladder problems.
There is also a risk of hypoglycemia (low blood sugar) with semaglutide, especially in individuals with diabetes or those taking insulin or other blood sugar-lowering medications. It is important for patients taking semaglutide to monitor their blood sugar levels closely and seek medical attention if they experience symptoms of hypoglycemia, such as dizziness, sweating, or confusion.
Additionally, there have been concerns about the long-term safety of semaglutide, particularly its potential to increase the risk of certain types of cancer. While studies have not shown a definitive link between semaglutide and cancer risk, more research is needed to fully understand the safety profile of this medication.
Cost and Accessibility of Semaglutide
One of the major drawbacks of semaglutide for weight loss is its cost. As a relatively new and innovative medication, semaglutide can be expensive, especially for individuals without insurance coverage. The high cost of semaglutide may limit access for some patients who could benefit from its weight loss effects.
Furthermore, semaglutide is currently only available as an injectable medication, which may be a barrier for individuals who are uncomfortable with self-injections or have a fear of needles. The inconvenience of daily injections may also affect adherence to treatment, potentially impacting the effectiveness of semaglutide for weight loss.
Despite these barriers, the potential benefits of semaglutide for weight loss are significant, and many patients may find the investment worthwhile if other weight loss strategies have been unsuccessful. It is important for individuals considering semaglutide to weigh the pros and cons carefully with their healthcare provider to determine if this medication is the right choice for their weight loss goals.
Conclusion
Semaglutide shows promise as a novel treatment for weight loss, with proven effectiveness in clinical trials and potential benefits for metabolic health. However, like any medication, semaglutide is not without risks, and patients should be aware of the potential side effects and long-term safety concerns associated with this medication. Ultimately, the decision to take semaglutide for weight loss should be made in consultation with a healthcare provider, taking into consideration individual health needs, cost considerations, and treatment preferences.
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Dr. Mejia is back with important information regarding GLP-1 medications! He's sharing the latest news about fasting before surgery if you take medications like ozempic or tirzepatide. Patient safety is the top priority!
If you're currently using GLP-1 medications like Semaglutide or Tirzepatide for weight loss or blood sugar control, I want to share an important new update that can help keep you safe during any upcoming medical procedures."
A new consensus statement, published in the British Journal of Anesthesia and co-sponsored by the American Association of Clinical Endocrinology, now recommends That you should fast from solid food for at least 24 hours before going under anesthesia—even for a routine procedure.
That you should only stick to clear liquids during this time.
And that you can continue your GLP-1 medication if you’re tolerating it well.
So, Why do you need to fast for 24 hours before anesthesia?
As you all know, GLP-1 medications slow gastric emptying to help with weight loss and blood sugar control. However, that same effect can leave food in your stomach longer. If you go under anesthesia with undigested food present, you may be at increased risk of aspiration—a serious complication.
These new guidelines were based on a comprehensive review of 112 studies and developed using a rigorous consensus method. As lead author explains:
“Fasting times are the most important factor to reduce the risk of residual gastric content in patients on GLP-1s.”
So the bottom line is this:
If you're scheduled for a procedure that requires anesthesia, you do not have to stop your GLP-1 if you are tolerating them well, but be sure to fast from solids for 24 hours, and only consume clear liquids.
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