This Harvard Medical School Continuing Education video examines these key questions: What role do GLP1 receptor agonists (GLP1 RA) play in weight loss? What are the risks and benefits of using GLP1 RA for weight loss?
Lee-Shing Chang, MD, an endocrinologist at Brigham and Women’s Hospital, identifies FDA-approved medications for weight loss and explains GLP1 and the role GLP1 receptor agonists play in weight management. Key studies including the SCALE and STEP trials are highlighted and the efficacy of the GLP-1 receptor agonists liraglutide and semaglutide are compared.
00:00 | Introduction
00:37 | Pharmacotherapy for weight management
01:25 | What is GLP1 and what does it do?
02:35 | Clinical trials of liraglutide and semaglutide for weight loss
This video was peer reviewed by Dr. Jonathan Salik, TMD, MHPEd, Instructor of Medicine, Massachusetts General Hospital; and Dr. Sugantha Sundar, MD, Assistant Professor of Anesthesia, Beth Israel Deaconess Medical Center, to validate the quality and accuracy of the content.
References:
Muskiet MHA, Tonneijck L, Smits MM, et al. GLP-1 and the kidney: from physiology to pharmacology and outcomes in diabetes. Nat Rev Nephrol. 2017;13(10):605-628. doi:10.1038/nrneph.2017.123
Pi-Sunyer X, Astrup A, Fujioka K, et al. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. N Engl J Med. 2015;373(1):11-22. doi:10.1056/NEJMoa1411892
Wilding JPH, Batterham RL, Calanna S, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989. doi:10.1056/NEJMoa2032183
Rubino DM, Greenway FL, Khalid U, et al. Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial. JAMA. 2022;327(2):138-150.
Rubino D, Abrahamsson N, Davies M, et al. Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial. JAMA. 2021;325(14):1414-1425. doi:10.1001/jama.2021.3224
Notice: At this time, the content in this video is not accredited.
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Primero de todo, gracias por tu tiempo y espero que te haya gustado el vídeo, no olvides suscribirte (si aún no lo estas) y en darle al me gusta. Es muy importante para mí para seguir creciendo.
Si quisieras que tocara un nuevo tema, déjamelo en comentarios. Y si queréis apoyarme en esta travesía únete como miembro del canal y me apoyarás directamente y además tendrás la opción de resolver dudas personalmente y tener los yanezaptos de los principales y más conocidos supermercados nacionales.
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Para descuentos en SCIENTIFFIC NUTRITION utilizad el código = YANEZ
Os dejo la bibliografía a continuación:
Amini, M. R., Sheikhhossein, F., Naghshi, S., Djafari, F., Askari, M., Shahinfar, H., ... & Shab-Bidar, S. (2020). Effects of berberine and barberry on anthropometric measures: A systematic review and meta-analysis of randomized controlled trials. Complementary therapies in medicine, 49, 102337.
Asbaghi, O., Ghanbari, N., Reiner, Ž., Amirani, E., Hallajzadeh, J., Mirsafaei, L., & Asemi, Z. (2020). The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials. Clinical Nutrition ESPEN, 38, 43-49.
Fisher, L. (2021). Retraction: Berberine alleviates amyloid beta-induced injury in Alzheimer’s disease by miR-107/ZNF217. RSC Advances, 11(9), 5001-5001.
Lu, Z., Lu, F., Wu, L., He, B., Chen, Z., & Yan, M. (2021). Berberine attenuates non-alcoholic steatohepatitis by regulating chemerin/CMKLR1 signalling pathway and Treg/Th17 ratio. Naunyn-Schmiedeberg's Archives of Pharmacology, 394(2), 383-390.
Qiu, F., Lu, W., Ye, S., Liu, H., Zeng, Q., Huang, H., ... & Dai, Z. (2021). Berberine Promotes Induction of Immunological Tolerance to an Allograft via Downregulating Memory CD8+ T-Cells Through Altering the Gut Microbiota. Frontiers in immunology, 12, 324.
Wang, Y., Tai, Y. L., Zhao, D., Zhang, Y., Yan, J., Kakiyama, G., ... & Zhou, H. (2021). Berberine Prevents Disease Progression of Nonalcoholic Steatohepatitis through Modulating Multiple Pathways. Cells, 10(2), 210.
Wang, Y., Tong, Q., Ma, S. R., Zhao, Z. X., Pan, L. B., Cong, L., ... & Jiang, J. D. (2021). Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota. Signal transduction and targeted therapy, 6(1), 1-20.
Wang, Y., Tong, Q., Ma, S. R., Zhao, Z. X., Pan, L. B., Cong, L., ... & Jiang, J. D. (2021). Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota. Signal transduction and targeted therapy, 6(1), 1-20.
Xiong, X., Cheng, Z., Wu, F., Hu, M., Liu, Z., Dong, R., & Chen, G. (2021). Berberine in the treatment of ulcerative colitis: A possible pathway through Tuft cells. Biomedicine & Pharmacotherapy, 134, 111129.
Yan, Y. Q., Fu, Y. J., Wu, S., Qin, H. Q., Zhen, X., Song, B. M., ... & Jiang, Z. Y. (2018). Anti‐influenza activity of berberine improves prognosis by reducing viral replication in mice. Phytotherapy research, 32(12), 2560-2567.
Zhang, D., Jiang, L., Wang, M., Jin, M., Zhang, X., Liu, D., ... & Xu, X. (2021). Berberine inhibits intestinal epithelial barrier dysfunction in colon caused by peritoneal dialysis fluid by improving cell migration. Journal of Ethnopharmacology, 264, 113206.
Zhao, Y., Yang, X., Zhao, J., Gao, M., Zhang, M., Shi, T., ... & Chen, L. (2021). Berberine inhibits chemotherapy-exacerbated ovarian cancer stem cell-like characteristics and metastasis through GLI1. European Journal of Pharmacology, 895, 173887.
Espero que aprendáis algo nuevo sobre #dietas #alimentación #nutrición #entrenamiento #salud #yanezaptovideo #yanezapto #estilodevida #comida
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Si tenéis alguna duda o queréis que toque algún tema más dejádmela en comentarios y si os ha gustado pues dadle un like muy apto y compartid con vuestros conocidos.
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Drink enough water to make a difference. This episode features audio from:
https://nutritionfacts.org/video/does-drinking-more-water-help-you-lose-weight/
https://nutritionfacts.org/video/how-much-water-should-you-drink-every-day-to-lose-weight/
Visit the video pages for all sources and doctor's notes related to this podcast.
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How Much Water To Drink To Lose Weight In 3 Days
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There are many reasons why you might want to lose weight. If you have been significantly overweight or obese for a long time, then you might have concerns about what the extra weight could be doing to your health. Obesity increases your risk of many health problems, including diabetes, non-alcoholic fatty liver disease, gallbladder disease, and some types of cancer.[1] If you have recently gained a bit of weight, then you might just want to lose some weight to fit back into your old jeans. Whatever your reason for wanting to lose weight, there are some important strategies that you should know about.
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Are you looking to shed some extra pounds and transform your diet? Oprah Winfrey may have just the solution for you with her latest product – ACV Weight Loss Gummies. These gummies claim to harness the power of apple cider vinegar (ACV) to support weight loss and improve overall health. But do they really work? In this article, we will take a closer look at Oprah’s ACV Weight Loss Gummies and explore whether they can truly transform your diet.
The Power of Apple Cider Vinegar
Apple cider vinegar has long been touted for its potential health benefits, including aiding in weight loss. ACV is made from fermented apple juice and contains acetic acid, which is believed to help suppress appetite, increase metabolism, and reduce fat storage. Some studies have shown that consuming apple cider vinegar can lead to modest weight loss and improved body composition.
However, it is essential to note that the effects of apple cider vinegar on weight loss are not drastic, and results may vary from person to person. While ACV can be a useful tool in a weight loss journey, it is essential to combine it with a healthy diet and regular exercise for the best results.
Oprah’s ACV Weight Loss Gummies aim to provide a convenient and tasty way to incorporate apple cider vinegar into your daily routine. These gummies are infused with ACV and other ingredients that are believed to support weight loss, making it easier for users to reap the benefits of ACV without the unpleasant taste and smell.
Benefits of Oprah’s ACV Weight Loss Gummies
One of the main benefits of Oprah’s ACV Weight Loss Gummies is their convenience. Unlike traditional liquid apple cider vinegar, these gummies are easy to take on the go and can be incorporated into your daily routine without any hassle. This makes it easier for users to stay consistent with their ACV consumption and potentially see better results.
In addition to convenience, Oprah’s ACV Weight Loss Gummies also aim to improve the taste of apple cider vinegar. Many people find the strong taste and smell of ACV off-putting, making it challenging to incorporate into their diet. These gummies offer a more palatable option for users who want to enjoy the benefits of ACV without the unpleasant flavor.
Furthermore, Oprah’s ACV Weight Loss Gummies may provide additional health benefits beyond weight loss. Apple cider vinegar is believed to have antioxidant and antimicrobial properties, which can support overall health and well-being. By incorporating these gummies into your daily routine, you may experience improved digestion, better immune function, and increased energy levels.
Potential Drawbacks of Oprah’s ACV Weight Loss Gummies
While Oprah’s ACV Weight Loss Gummies offer many benefits, it is essential to consider potential drawbacks before incorporating them into your diet. One concern is the added sugars and other ingredients in the gummies, which may not align with a healthy eating plan. Some gummies may contain high amounts of sugar, calories, or artificial additives, which can undermine weight loss efforts.
Additionally, the effectiveness of ACV gummies compared to traditional liquid ACV is a topic of debate among health experts. Some argue that the process of turning ACV into a gummy form may reduce its potency and effectiveness, leading to fewer benefits for the user. It is essential to research the quality and ingredients of Oprah’s ACV Weight Loss Gummies before making a purchase.
Lastly, while ACV can support weight loss, it is not a magic solution on its own. To see significant results, it is crucial to combine ACV consumption with a balanced diet, regular exercise, and healthy lifestyle habits. Oprah’s ACV Weight Loss Gummies should be used as part of a comprehensive weight loss plan, rather than a standalone solution.
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Kelly Clarkson Says Being Told She's 'Pre-Diabetic' Prompted Recent Weight Loss
The three-time Grammy winner has embraced a more active lifestyle since moving cross-country.
