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Family practitioner Catherine Varney, DO is the Obesity Medicine Director for UVA Health. Katie George, DNP, AG-ACNP, is a board-certified Adult-Gerontology Acute Care Nurse Practitioner within the UVA Department of Family Medicine. They speak with us about caring for patients who live with obesity.
Learn more at: https://blog.uvahealth.com/2025/01/07/weight-loss-medication/
Transcript
Catherine Varney, DO: Patients coming to UVA Health and our Obesity Medicine clinic can expect a very individualized plan. Some people just need lifestyle changes and don't need medications, but if those medications are indicated and the patient would like to explore that, we see which one is best for them and we try to pick the right medication based on their overall health and other medications that they're taking.
Katie George, DNP, AG-ACNP: Obesity medication is indicated for patients that have a BMI of 27 or greater with a comorbidity. And the typical comorbidities that are included in that are high blood pressure or hypertension, hyperlipidemia or high cholesterol or type two diabetes, or a BMI greater than 30.
Catherine Varney: So anti-obesity medications have been used since the 1960s, and there's lots of options out there. And some of the ones that we were using in the '60s we still use today. But there are new medications, a newer generation of anti-obesity medications that seems to be kind of the hot topic right now. And they're very safe, they're very effective. And we previously used them for treatment of type two diabetes, and so we have almost 20 years of data showing their safety. So we pick those medications based on what's right for the patient, and also we have to consider what's covered and affordable for patients.
Katie George: As far as what risks are involved with medication treatment, I think you have to first step back and ask what are the risks associated with not treating the disease process? So I tell patients, we basically have two buckets when we're looking at medical therapy. We have oral therapy or pills. We also have the GLP-1 receptor agonist injections that get so much attention in the media.The GLP-1 receptor agonist injections, some people have no side effects whatsoever. Most people have mild-to-moderate nausea, but it can be mitigated and managed with dietary modifications. Other side effects can include other GI side effects, including constipation or diarrhea. Some people will tell me, "I know I'm not going to feel great for a day or so." But then they look back six months or a year later, and I have had people say to me, "Oh my gosh, I thought those side effects were so bad. I am so glad I stuck with this."In the care of the patient that has obesity, we have a really broad team base that supports the work we do. The entire team is really passionate about taking care of patients that are struggling with weight.
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Tirzepatide and Semaglutide are two promising medications that have recently gained attention for their potential in helping individuals achieve weight loss. Both drugs belong to a class of medications known as GLP-1 receptor agonists, which work by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1) in the body. GLP-1 helps to regulate blood sugar levels, reduce appetite, and promote weight loss. In this article, we will compare Tirzepatide and Semaglutide in terms of their weight loss outcomes and effectiveness.
Tirzepatide
Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist that is being developed by Eli Lilly for the treatment of type 2 diabetes and obesity. It is currently in phase 3 clinical trials for these indications. Tirzepatide has shown promising results in early studies, with significant reductions in body weight observed in patients with obesity and type 2 diabetes.
Tirzepatide works by stimulating both the GIP and GLP-1 receptors, which leads to increased insulin secretion, reduced appetite, and improved glycemic control. This dual mechanism of action may make Tirzepatide more effective at promoting weight loss compared to other GLP-1 receptor agonists. Clinical trials have reported that patients treated with Tirzepatide experienced greater reductions in body weight compared to those treated with Semaglutide.
One of the potential advantages of Tirzepatide is its dosing flexibility. It is available in a once-weekly or once-monthly injection, which may be more convenient for patients compared to daily injections. This dosing flexibility may also improve patient adherence to treatment, leading to better weight loss outcomes in the long term.
Semaglutide
Semaglutide is a long-acting GLP-1 receptor agonist that is currently approved for the treatment of type 2 diabetes under the brand name Ozempic. In addition to its glucose-lowering effects, Semaglutide has also been shown to promote weight loss in patients with obesity. It is available as a once-weekly injection.
Recent clinical trials have demonstrated that Semaglutide is highly effective at promoting weight loss, with some patients achieving significant reductions in body weight of up to 15% or more. Semaglutide works by activating the GLP-1 receptors in the body, which leads to increased insulin secretion, decreased appetite, and reduced food intake.
One of the key advantages of Semaglutide is its proven track record in promoting weight loss. It has been extensively studied in clinical trials and has consistently shown efficacy in helping patients achieve and maintain weight loss. Semaglutide may be a preferred option for patients who have not achieved their weight loss goals with other medications or lifestyle interventions.
Comparison
When comparing Tirzepatide and Semaglutide for weight loss outcomes, several factors should be considered, including efficacy, dosing convenience, and side effects. Both medications have shown promising results in promoting weight loss, but there may be differences in their effectiveness and tolerability for individual patients.
In clinical trials, both Tirzepatide and Semaglutide have demonstrated significant reductions in body weight, with Semaglutide showing slightly greater weight loss outcomes in some studies. However, Tirzepatide’s dual mechanism of action may make it more effective for certain patients who do not respond well to traditional GLP-1 receptor agonists.
Ultimately, the choice between Tirzepatide and Semaglutide will depend on individual patient factors, such as treatment goals, preferences, and medical history. It is important for patients to discuss their options with their healthcare provider to determine the most suitable treatment for their weight loss journey.
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Embracing Change: The Journey of Kelly Clarkson
Kelly Clarkson is a name that resonates with many. She burst onto the music scene as the winner of the first season of American Idol in 2002, capturing hearts with her powerful voice and infectious personality. However, beyond the glitz and glamour of Hollywood, Clarkson’s journey has been marked by struggles and triumphs, one of which includes her remarkable weight loss transformation. Over the years, she has candidly shared her struggles with body image, weight fluctuations, and the pursuit of self-acceptance. This article delves deep into Kelly Clarkson’s transformative journey, exploring how she managed to shed the pounds while maintaining a positive mindset. Clarkson’s evolution is not just about weight loss; it encapsulates empowerment, resilience, and the pursuit of a healthier lifestyle.
In a world where societal pressures dictate beauty standards, Kelly has been outspoken about her body image struggles. She experienced significant weight changes throughout her music career, often feeling the weight of expectations from the public and media. Clarkson’s candid conversations surrounding her body have encouraged many to embrace their unique journeys. Rather than succumbing to societal pressures, she made a conscious decision to focus on her health rather than simply losing weight for aesthetics. This approach parallels a broader cultural shift towards accepting body diversity and promoting health at every size.
Furthermore, Kelly’s journey highlights the importance of mental health in the pursuit of physical well-being. Through her weight loss story, she emphasizes the significance of mental clarity, stress management, and self-care routines. Her openness about the emotional aspect of weight loss has offered solace and support to many, reminding individuals that our worth is not determined by a number on a scale but rather by how we feel within our own bodies. By sharing her personal experiences, Clarkson encourages others to pursue their health goals holistically, blending physical fitness with emotional stability.
The Start of a New Chapter
The journey of Kelly Clarkson’s weight loss began with a personal commitment to change. After years of fluctuating weight, she reached a turning point where she decided that her health needed to be a priority. Acknowledging the toll that constant dieting and body image issues took on her mental health, Clarkson sought a more sustainable approach to weight management. Instead of restrictive diets, she started focusing on moderation, balanced nutrition, and regular physical activity. This pivotal shift illuminated a path towards not only losing weight but also enhancing her overall wellness.
In her journey, Clarkson has emphasized the importance of finding a workout routine that aligns with her lifestyle. She explored various fitness modalities, ultimately discovering that enjoyable activities were essential for maintaining motivation. From strength training to cardio, she shared that exercise should never feel like a punishment but rather an empowering tool for self-improvement. Moreover, she often engaged in workouts that fit her schedule as a busy mom and artist, showcasing that even small increments of physical activity can lead to substantial health benefits over time.
Nutrition played a crucial role in Clarkson’s transformation. Transitioning from a mindset of deprivation to one of nourishment allowed her to build a healthier relationship with food. Her focus became incorporating wholesome, nutrient-dense foods into her meals while still indulging in her favorite treats occasionally. This balance illustrates her commitment to a sustainable lifestyle change rather than a quick fix. Throughout this process, Clarkson learned to listen to her body, honing in on hunger cues and understanding when to eat for fuel or enjoyment—a practice that many strive to master in their own journeys.
The Role of Mindset in Transformation
The significance of mindset in Kelly Clarkson’s weight loss journey cannot be overstated. Acknowledging the emotional component of health, she has expressed that a positive outlook is pivotal for achieving lasting change. Cultivating a mindset focused on appreciation and self-love rather than self-criticism allowed Clarkson to navigate her transformation more compassionately. She voiced that consistent self-affirmation helps in battling negative thoughts and building confidence, which ultimately contributes to a healthier approach to weight management.
Furthermore, Clarkson’s story resonates with many who grapple with societal expectations and the pressure to conform to certain body ideals. By sharing her experiences publicly, she has inspired countless individuals to redefine success in their health journeys. Kelly emphasizes that health looks different for everyone, and it is about finding what works for the individual. Rather than comparing oneself to others, she advocates for focusing on personal goals and progress, which often leads to more sustainable and fulfilling outcomes.
Tracking emotional well-being is also essential to his narrative. Clarkson has underscored the importance of mental health in the weight loss equation—it’s about feeling good, being active, and emotionally supporting oneself. She has often advocated for seeking professional help when necessary offering workshops or support groups can be transformational for anyone struggling with similar issues. Recognizing when to ask for help and understanding that it’s okay to not have everything figured out are vital steps in the journey to health and happiness.
Celebrating Achievements and Lessons Learned
As Kelly Clarkson continues her journey, she is open about celebrating each milestone, no matter how big or small. She has learned to take pride in her achievements and appreciates the journey of self-discovery that her weight loss has sparked. Rather than fixating solely on the number on the scale, Clarkson now values the strength, energy, and confidence that come with her healthier lifestyle. Each stride forward represents a commitment to wellness and embracing a life that supports her goals as an artist, mother, and individual.
In her reflections, Kelly often highlights the lessons learned along the way. One of the most crucial takeaways is the understanding that health is not linear; there will be ups and downs in the process. By reframing setbacks as learning experiences, she encourages her followers to be kind to themselves and remember that consistency over time yields results. Her resilience exemplifies the notion that commitment to oneself is what truly matters in the long run.
Celebrating progress also includes acknowledging the supports that surround her. Clarkson attributes part of her success to her loved ones, who play an instrumental role in her journey. Having a solid support system fosters motivation and creates an environment where healthy habits can flourish. She often emphasizes the importance of community, urging others to connect with those who uplift them and share similar aspirations. In this way, her journey becomes a collective narrative that inspires and empowers those around her.
Navigating Challenges and Inspiring Others
Despite the success Kelly Clarkson has experienced in her weight loss journey, she has encountered challenges along the way. It is critical to acknowledge that transformation does not come without its hurdles. Whether it is balancing her career in the entertainment industry with her personal life or handling public scrutiny, Clarkson’s vulnerability has become a beacon of hope for many. By discussing both her triumphs and struggles openly, she inspires others to speak about their own experiences and destigmatize conversations around body image and emotional health.
Moreover, Clarkson’s platform as a celebrity amplifies her outreach, allowing her to influence broader discussions on health and wellness. She has utilized her voice to encourage healthy habits, self-acceptance, and the importance of mental health advocacy. Her authenticity fosters a culture that embraces individual journeys rather than creating unrealistic standards based on appearance. Thus, Clarkson has forged a path for empowerment, urging her audience to embrace their uniqueness and to prioritize well-being.
In closing, Kelly Clarkson’s journey serves as an inspiration; it highlights the interplay between physical change and emotional growth. By being transparent about her road to weight loss, she invites others to reflect on their own experiences with body image issues and societal pressures. Her story encourages a sense of community and shared understanding, reinforcing that everyone deserves to celebrate their own unique transformation story, regardless of where they begin.
Frequently Asked Questions about Kelly Clarkson’s Transformation
Many fans and followers have been curious about Kelly Clarkson’s transformation journey. The frequently asked questions reflect the desire for understanding and the inspiration drawn from her story. One frequently asked question revolves around the specifics of Clarkson’s weight loss plan. While she has shared elements of her regimen, like embracing a balanced diet and regular exercise, she emphasizes that there is no one-size-fits-all approach. Each person’s journey in health and fitness is highly personal and should be tailored to individual needs and goals.
Another popular inquiry concerns her mental approach to weight loss. Clarkson advocates for a mindset that prioritizes self-love and appreciation over comparison. She believes that fostering a positive relationship with oneself can significantly enhance the journey toward health. Fans often inquire about the emotional challenges she faced during her transformation, and she has openly discussed moments of insecurity. However, she reiterates the importance of resilience and self-compassion, reminding others that setbacks can be part of the process.
Many people also wonder how Kelly balances her busy career with her commitment to a healthy lifestyle. Clarkson shares that time management is critical; she prioritizes her health by scheduling workouts and meal prep into her routine. Despite her hectic lifestyle, she emphasizes that even small, consistent efforts can lead to significant change over time. Ultimately, her journey serves as a motivational blueprint for those seeking genuine transformation—illustrating that dedication to health can coexist with a fulfilling life, inspiring a community ready to support one another.
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Semaglutide, a medication originally developed to treat type 2 diabetes, has recently gained popularity for its potential as a weight loss aid. Clinical trials have shown promising results, with participants experiencing significant reductions in body weight when taking semaglutide. However, determining the optimal dosage for weight loss can be a complex process, as individual responses to the medication can vary. In this article, we will explore the factors that influence semaglutide dosage for weight loss and how to determine the right amount for you.
Factors Influencing Semaglutide Dosage
When prescribing semaglutide for weight loss, healthcare providers take several factors into consideration to determine the optimal dosage for each individual. One important factor is the patient’s current weight and body mass index (BMI). Higher doses of semaglutide may be prescribed for individuals with a higher BMI, as they may require more medication to achieve significant weight loss.
Another factor that influences semaglutide dosage is the individual’s response to the medication. Some patients may experience more significant weight loss with lower doses of semaglutide, while others may require higher doses to see the same results. Healthcare providers may adjust the dosage based on the patient’s weight loss progress and any side effects they may be experiencing.
Additionally, healthcare providers take into account any underlying health conditions that the patient may have when determining the optimal semaglutide dosage for weight loss. Certain health conditions, such as cardiovascular disease or kidney impairment, may require a lower dosage of semaglutide to minimize potential risks and side effects.
Determining the Right Semaglutide Dosage for You
When starting semaglutide for weight loss, it is important to work closely with your healthcare provider to determine the right dosage for you. Your healthcare provider will consider your individual characteristics, such as your weight, BMI, and any underlying health conditions, to prescribe the most effective dose of semaglutide for your weight loss goals.
It is essential to follow your healthcare provider’s instructions carefully when taking semaglutide for weight loss. Do not adjust the dosage on your own or take more medication than prescribed, as this can increase the risk of side effects and complications. If you experience any side effects or have concerns about your dosage, contact your healthcare provider immediately.
In conclusion, determining the optimal semaglutide dosage for weight loss is a personalized process that takes into account individual factors such as weight, BMI, response to the medication, and underlying health conditions. By working closely with your healthcare provider and following their guidance, you can achieve significant weight loss results with semaglutide while minimizing any potential risks or side effects.
Summary and FAQ
In this article, we discussed the factors that influence semaglutide dosage for weight loss and how to determine the right amount for you. It is essential to work closely with your healthcare provider to find the optimal dosage that will help you achieve your weight loss goals safely and effectively.
Here are some frequently asked questions about semaglutide dosage for weight loss:
1. How long does it take to see weight loss results with semaglutide?
2. What are the common side effects of semaglutide for weight loss?
3. Can I take semaglutide if I have a history of diabetes or cardiovascular disease?
4. How often do I need to follow up with my healthcare provider while taking semaglutide for weight loss?
5. Is semaglutide safe for long-term use for weight loss?
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Christina Aguilera Looks 'Unrecognizable' On The Stage In Mexico City After 40 Lb Weight Loss
Christina Aguilera, a Grammy winner, has been rumored to be undergoing weight loss medication, Ozempic, due to her appearance at the Tecate Emblema Festival in Mexico City. Despite her 40-lb weight loss, many fans believe she looks unrecognizable, with her slimmer frame and racy outfit. Aguilera has never confessed to taking Ozempic, but fans believe she must be taking the weight loss medication. Despite her seemingly unrecognizable appearance, many fans are gushing over her appearance, with some comparing her to a teenager and others comparing her to Ozempic. Some fans have even commented on her aging backwards, comparing her to a 25-year-old girl.
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