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Struggling to find Ozempic or Mounjaro? You're not alone! In this video, we explore the skyrocketing demand and supply shortages of weight loss medications like Ozempic (Semaglutide) and Mounjaro (Tirzepatide). Discover the frustrations of patients and doctors, the impact of insurance barriers, compounded medication bans, and cultural perceptions shaping accessibility in the US and Australia. Whether you're a healthcare professional or someone searching for solutions, this episode breaks it down with evidence-based insights. Stay informed on these hot health topics and join the conversation about the future of obesity treatments. Ozempic = Semaglutide (the US and Australia) Wegovy (= Semaglutide, Australia only, weight loss) Mounjaro = Tirzepatide (the US and Australia Zepbound (= Tirzepatide, the US only, weight loss, sleep apnoea) REFERENCES Weight regain after discontinuing medications like Ozempic and Mounjaro 1. “Discontinuation of semaglutide and weight regain”Diabetes, Obesity and Metabolism (2022) 2. “Here’s How Much Weight People Regain After Stopping Mounjaro or Zepbound” Author: Sarah Fielding; Healthline (2023) 3. “Effect of Continued vs Discontinued Semaglutide Treatment on Weight Maintenance” Authors: Rubino D, Greenway FL, Khalid U, et al.;The Lancet Diabetes & Endocrinology (2021) The Frustration and Struggles of Physicians 1.“Insurance Coverage of Obesity Medications.” JAMA. 2022 2.“Obesity Medications and Access to Care: Challenges in Insurance Coverage.” Obesity Medicine News, 2023. 3. “Barriers to Accessing FDA-Approved Obesity Medications.” American Journal of Managed Care. 2023 4. “Insurance Barriers and Access to Weight Loss Drugs.” Endocrine Reviews, 2023. 5. “Economic Impact of Insurance Denials on Obesity Treatment Access.” Health Affairs. 2023 6. Australian Physicians’ Concerns: RACGP; Simple Online Doctor Australia Accessibility and Supply: TGA.gov.au; RACGP; (Source: Chemist2U) Compounded Medications Ban: RACGP; Diabetes Victoria; Private Health Insurance Landscape; Insurance Business Australia; Bupa FAQs Approval and Prescribing Practices: (Source: TGA, Source: RACGP). PBS Subsidies and Costs: Health.gov.au; MyDr.com.au United States Approval and Prescribing Practices: (Source: FDA, Source: Lilly Pricing Info). Accessibility and Supply: (Source: FDA) Cultural Perception and Media Coverage Australia:(Source: The Australian) United States:(Source: Bloomberg) #Ozempic, #Mounjaro, #WeightLossMedication, #HealthPodcast, #Semaglutide, #Tirzepatide, #ObesityTreatment, #InsuranceBarriers, #Wegovy, #Zepbound, #HealthTips, #WeightLossJourney, #HealthCareAccess, #AustraliaHealth, #USHealth
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GLP-1 agonist medications have been a popular topic of discussion recently. While this weight loss drug was designed for obesity, GLP-1 agonists like Ozempic have made their way into Hollywood. This has people questioning their safety and possible health risks, especially in the long run. Are GLP-1 agonists a quick fix for weight loss or a lifetime prescription? Who should be prescribed this medication, and what are the possible side effects? This Longevity by Design episode features an interview with Dr. Spencer Nadolsky—An obesity and lipid specialist physician. Dr. Nadolsky explains how GLP-1 medications cause weight loss, answers questions about safety concerns, and discusses interesting patient stories about how people react to this medication. Dr. Nadolsky has extensive patient experience with GLP-1 agonist drugs and is very knowledgeable about their current use and future potential. Why Dr. Nadolsky became a physician: (2:00–4:13) What is cardiometabolic medicine?: (4:13–5:17) What is a “healthy” metabolism?: (5:17–7:37) How does diet impact glucose regulation: (7:37–10:20) Why has insulin resistance increased in the past decade?: (10:20–11:45) Ethnicity impacts BMI cutoffs: (11:45–12:57) Is obesity a choice?: (12:57–17:40) How socioeconomic status impacts obesity: (17:40–21:30) What's better: A BMI score or a DEXA scan?: (21:30–25:33) How strength training improves healthspan: (25:33–32:32) What a fasting insulin blood test tells you: (32:32–36:58) Health risks of insulin resistance: (35:15–38:08) How insulin resistance can increase ApoB: (38:08–39:25) How does ApoB predict heart disease risk?: (39:25–42:50) Why isn't ApoB included in typical lipid panels?: (42:50–44:25) Behavioral science and clinical practice: (44:25–50:06) How do GLP-1 agonists cause weight loss? (50:06–56:03) Negative side effects of GLP-1 medications: (56:03–57:36) Price of GLP-1s: (57:36–58:53) GLP-1: A short term quick fix or a lifetime prescription?: (58:53–1:02:19) Biggest health myths on social media: (1:02:19–1:08:45) Top tip for healthspan: (1:08:45–end) Longevity by Design is produced by InsideTracker, your data-driven wellness guide for optimizing your healthspan. For a limited time, visit https://hubs.li/Q021Z4gp0 for 20% off any InsideTracker plan. __________________________________________ Let’s Connect! Instagram - https://www.instagram.com/insidetracker Twitter - https://twitter.com/InsideTracker Facebook - https://www.facebook.com/InsideTracker LinkedIn- https://www.linkedin.com/company/insi... TikTok- https://www.tiktok.com/@insidetracker_ Pinterest- https://www.pinterest.com/insidetrack... Website - https://www.insidetracker.com/ In the Press - https://www.insidetracker.com/press-p...
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Downsized News: Breakthroughs and Industry Shifts in GLP-1 Treatments In this episode of the Downsized News, Laraine and Christopher Durham deliver the latest updates on GLP-1 medications on Monday, June 2nd, 2025. Key topics include significant data releases by Eli Lilly at the upcoming American Diabetes Association's Scientific Sessions concerning Tirzepatide's effects on kidney function and weight loss compared to Semaglutide. The episode also explores new forms of GLP-1 treatments, such as the Orfroglipron pill and the Retatrutide triple-action hormone, as well as an updated weekly insulin option by Lilly. Additionally, a comprehensive breakdown of a study on high-dose Semaglutide treatments for diabetes and obesity discusses the balance between increased weight loss and rising side effects. The discussion shifts to industry challenges, like Hims Inc.'s layoffs due to FDA crackdowns on compounded GLP-1s, and a new ISSA course designed to help athletic trainers support GLP-1 users. Also covered is the intense industry debate over compounded medications, a major court ruling in India impacting Semaglutide sales, and competitive developments in China's obesity treatment market. The episode concludes with highlights of an innovative partnership between Nxtera Pharma and Eli Lilly aiming at new metabolic treatments. The hosts encourage viewers to stay informed and share personal insights on navigating GLP-1 treatments. DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store Join CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED WEBSITE: https://thedownsized.org/ FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Introduction and Overview 01:04 Eli Lilly's Latest Data and Innovations 05:21 High Dose Semaglutide Study Insights 10:14 Hims Layoffs and FDA Crackdown 11:51 New Training Course for GLP-1 Trainers 13:58 Compounded Medications Debate 17:08 Legal Battles and Market Dynamics in India 20:16 NextEra Pharma and Eli Lilly Partnership 21:52 Upcoming Competition in China's GLP-1 Market 24:25 Conclusion and Final Thoughts
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