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Tips and Tricks for Semaglutide, Ozempic and Wegovy Hi, I am Dr. Craig Primack, and today I'm coming to you from Scottsdale Weight Loss Center. It has been quite some time since I've done a medical minute. Semaglutide So this weight loss drug is called semaglutide. It is a GLP-1 style drug. What does that mean? So semaglutide comes in two forms. The first form is something called Ozempic, in this blue pen. And the other one is called Wegovy, in the white pen. It is the same drug, although it is a different delivery system. You and I both have a hormone called GLP-1. It comes from the small intestine, the ileum, the area right past the stomach. The way I think about it is as food goes through the stomach and gets to the small intestine, the body is absorbing it. Even though that's not exactly what it's doing, it kind of says that "I'm full" and sends a hormonal signal to the brain that tells your body "I'm full" so you don't go out and get more food right away, because it's working on absorbing that food right then and there. The half life, so the amount of time that this hormone lasts in your system, half of it is gone in two minutes. And another quarter of it would be gone in a little bit later. So in a couple minutes, let's call it 10 minutes or less, that hormonal signal is completely gone. This is an artificial form of the drug GLP-1 called semaglutide. And the half life is a week long. It lasts in your system for a week at a time. So your body fuels fullness all the time. That is a great benefit for many of us in weight loss. Tips and Tricks So I'm going to show you a few tips and tricks I've learned throughout the last year. The first part is when should I take this drug? It is a once a week drug. When you read the package insert, it takes between one and three days to fully kick in. So I love to have my patients use this drug on a Wednesday. Why on a Wednesday? Because it takes between one and three days, so by Friday night, it's fully kicked in. It's fully kicked in through the rest of your... If there is social eating on the weekend, social eating. And then in the beginning at the lower doses, it may start to wear off before the end of your week. So maybe that's one day before on a Tuesday. Tuesday's typically not a big eating day. So first thing is Wednesday. Ozempic So the first one, Ozempic, you actually have to put a needle on. And what I'll show you is it has a cap on it right now. You take the cap off, you take this little needle and there's two pieces of plastic on the needle. You screw it on very simply. There's this first cap you take off right there. There's a second cap that you take off right there. And you guys can't see it, but this is a 32 gauge tiny, tiny needle. The next you do is you look at this little window where there's a zero. The first time you ever use the pen, you prime it by putting it to these first two little dots and you push the button and it goes back down to zero. That's before you even give yourself a dose. The next time you do it, you turn it all away, let's do it that way, to 0.25, which is about 18 clicks here. These little clicks. That may come into use in the future if we decide to try to adjust your dosing at all. But you put it at 0.25. You put this tiny little needle usually in your abdomen. It can go also in your thigh or arm and you push the button down. And as you can see, it goes all the way back to zero. When it goes back to zero, you then count to 5. 1, 2, 3, 4, 5, and you are done. Find a Sharps container. Or what I tell a lot of people is take an old medicine bottle, the yellow with the safety cap that's empty. Take this little needle off. Just like that. And throw it in your safety container. When it is full, then take it back to your pharmacy. So you do have to use, or at least touch the outside part of the needle on this one. Wegovy On Wegovy, another version of this, this is an auto injecting needle. You can see there's a little window here. What I have found is the best place to put this one, even though it can be in your abdomen or your arm, it is in your thigh when you're sitting in a chair. So you pull the plunger out and I'm going to show you the little window and pretend my thigh is my arm right here. And you push it down, you're going to hear two clicks. You're going to hear a click right away. You're going to see this little yellow bar. It's going to go about three quarter. Click again, and then move a little bit more. When it is done moving after the second click you are done, you never saw a needle and you have the full dose in you. Both of these medicines are adjusted somewhat differently, so please ask your medical professional what is the best way to do that. Hopefully this has helped you a little bit learn something about semaglutide, a great drug for many of us here in weight loss. I will be back soon with another medical minute.

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people keep telling me that injecting in the arm produces fewer side effects and creates higher weight loss! I'll be testing the theory myself! Let me just say OUCH 😌 that hurt! Debbie seemed unphased by it!

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Are GLP-1 medications like Ozempic and Wegovy a weight loss miracle—or just the latest trend? In this video, I break down what GLP-1 receptor agonists actually do, how effective they are according to the research, the side effects to know, and why they’ve taken over social media. We’ll look at the science behind semaglutide and tirzepatide, the celebrity effect, and the real risks and benefits. Whether you’re managing diabetes, obesity, or just curious about what’s driving the #Ozempic conversation, this video gives you the full picture—with evidence. #ozempic #weightlossjourney #doctorreacts #mounjaro #ozempicface __________________________________________________________________________ 📲 Follow Me on Instagram! 📸 @theradishhealer → https://www.instagram.com/theradishhealer __________________________________________________________________________ ⏱ Time Stamps: 00:00 – Intro: The GLP-1 Hype Explained 00:33 – What Are GLP-1 Agonists? (Ozempic, Wegovy, Mounjaro) 01:30 – Do They Actually Work? (STEP + SURMOUNT Trial Results) 02:56 – Appetite, Cravings & “Food Noise” 04:45 – The Celebrity Effect: Why These Drugs Went Viral 06:37 – Side Effects, Risks & Misconceptions 08:17 – When Are GLP-1s a Good Option? 09:37 – My Final Thoughts as a Doctor 10:15 – Outro + Link to Next Video (GLP-1 Foods) __________________________________________________________________________ 📚 Cited Studies: https://www.nejm.org/doi/full/10.1056/NEJMoa2206038 https://www.nejm.org/doi/full/10.1056/NEJMoa2032183 https://pubmed.ncbi.nlm.nih.gov/33755728/ __________________________________________________________________________ 👩‍⚕️ About Me Hey there! I’m Nisha, an internal medicine resident physician passionate about preventative care, lifestyle medicine, and making health & wellness accessible to everyone! Subscribe for more content on: ✅Evidence Based Medicine ✅Healthy lifestyle tips ✅Lifestyle vlogs 💜Don’t forget to LIKE & SUBSCRIBE for more videos! Thanks for watching! _________________________________________________________________________ DISCLAIMER: This video is for educational and informational purposes only and is not intended to provide medical advice, diagnosis, or treatment. Always consult with a licensed healthcare professional before making any changes to your diet, medications, or treatment plan. The information presented is based on current research but should not replace professional medical guidance tailored to your individual health needs. What I Eat In A Day For Fat Loss Episode 8 Dieting Weightmanagement

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Dr. Spencer Nadolsky joins Ethan on the American Glutton Podcast to dive into the revolutionary impact of GLP-1 drugs on obesity and cardiometabolic health, exploring their benefits, risks, and societal implications. From debunking myths about weight loss to discussing emerging treatments like myostatin inhibitors, they tackle the science and real-world applications head-on. The conversation also touches on the future of these medications, their potential to prevent weight gain, and the importance of combining them with lifestyle changes like resistance training. SHOW HIGHLIGHTS 00:00 - Introduction and Catching Up 00:35 - Obesity as a Choice and GLP-1 Drugs 01:58 - Misuse of GLP-1s and Social Media Hype 05:08 - The Science Behind GLP-1 and Incretin Effect 07:37 - How GLP-1 Drugs Work for Weight Loss 10:00 - Benefits vs. Risks of GLP-1 Drugs 11:57 - Common Side Effects and Nausea Discussion 13:15 - Fatigue and Anhedonia as Side Effects 14:54 - Fat Cell Memory and Weight Regain 17:41 - GLP-1s as a Breakthrough for Obesity 19:33 - Comparing Risks of GLP-1s to Other Drugs 20:24 - Big Pharma and Advisory Boards 23:57 - Importance of Protein and Resistance Training 27:34 - Myostatin Inhibitors and Muscle Growth 31:39 - Timeline for New Drug Approvals 33:31 - Drug Costs and Accessibility 37:51 - Comparing GLP-1 Drugs and Zepbound 39:57 - Glucagon and Triple Agonist Drugs 41:58 - Future of GLP-1s in Preventing Weight Gain 43:43 - Microdosing and Anti-Inflammatory Effects 44:33 - GLP-1s and Type 1 Diabetes Considerations 48:50 - Historical Context and Obesity Trends 52:37 - Moralizing Weight and Pharmaceutical Solutions 54:03 - Closing Thoughts and Future Support

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