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Start your year off by tuning in to the NEW EPISODE of Kickback Science: "Behind the Curtain: The Real Deal With GLP-1 Agonists". https://bit.ly/40fWMxC
Here is a clip where we are discussing some issues with the clinical trials that were done on the popular new GLP-1 weight-loss injections.
These medications have shown to be incredibly effective at helping people lose weight. The weight-loss is believed to be due to GLP-1's ability to activate satiety signaling (making people feel fuller), reducing reward-driven signals that trigger overeating, and slowing down digestion.. Yaaaaayyyy finally something to help stop my non-stop craving of chocolate chip cookie dough ice cream!!! Diet is the most difficult part of the weight-loss journey, and now we have a tool to make it easy?!!!
You're probably thinking that these medications sound too good to be true. And you might be right. You see, these clinical trials do a great job showing weight loss with these medications, but they fail to reports WHAT KIND OF WEIGHT the participants are losing (is it fat or muscle?). And that's because the FDA only requires pharmaceutical companies to report weight loss, as opposed to body composition changes. This is SUCH a bummer!
Fortunately, a small subset of participants in the STEP1 clinical trial (PMID: 33567185) underwent body composition testing (included in the supplemental files of the publication), which showed that they were losing almost as much muscle as fat. THIS IS NOT HEALTHY! If you haven't yet, tune in to the Kickback Science episode titled: "MUSCLE MANIA! Why Muscle is The Most Important Organ in Your Body". Then you'll understand what I mean when I say that there is reason to be concerned about the loss of muscle with these medications. https://bit.ly/3VXv9a8
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In her series on popular diets and cancer, Dartmouth Cancer Center clinical dietician Dianne Kelecy, MS, RD, LD, covers the “why or why not” of a ketogenic diet.
About Dartmouth Cancer Center: Dartmouth Cancer Center combines the advanced cancer research in partnership with Dartmouth and the Geisel School of Medicine, with award-winning, personalized, and compassionate patient-centered cancer care based at the Norris Cotton Cancer Care Pavilion at Dartmouth Hitchcock Medical Center. With 14 locations around New Hampshire and Vermont, Dartmouth Cancer Center is one of only 57 National Cancer Institute-designated Comprehensive Cancer Centers. Each year the Dartmouth Cancer Center schedules 74,000 appointments seeing more than 4,500 newly diagnosed patients and currently offers patients more than 240 active clinical trials. Celebrating its 50th anniversary in 2022, Dartmouth Cancer Center remains committed to excellence, outreach and education. We strive to prevent and cure cancer, enhance survivorship and to promote cancer health equity through pioneering interdisciplinary research and collaborations. Learn more at http://cancer.dartmouth.edu.
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