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Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA) originally formulated to treat diabetes, has gained traction as the latest and greatest weight loss drug. Amongst the hype, anecdotal observations from patients and providers alike have suggested the drug may also play a role in treating alcohol use disorder and other substance use disorders.

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The term ‘fat burning’ often gets thrown around & people assume it is the same thing as fat loss, it is NOT. Fat burning or fat oxidation (scientific term) are part of the process of losing body fat. You see, fat is stored in adipose tissue mostly as triacylglycerides. These stored TAGs must undergo lipolysis where the glycerol molecule & 3 fatty acid tails are cleaved from each other & released. Then those free fatty acids can undergo a process called beta-oxidation (I’m skipping over quite a few steps here to keep it simple) where the fats are oxidized. But fat burning does not occur in isolation. Fats are constantly being released from adipose tissue & burned but fats are also simultaneously being stored in adipose tissue. The simple equation looks something like this: Fat Balance = Rate of Fat Storage - Rate of Fat Burning So if Fat Storage more than Fat Burning, body fat is gained If Fat Storage is less than Fat Burning, body fat is lost If Fat Storage = Fat Burning, there is no change in body fat Low carb diets often claim superiority over other diets because they cause a large increase in fat burning. That is true, but it only tells one side of the story. You see, less than 2% of dietary carbohydrate is stored as body fat, & over 98% of fat stored in body fat originates as dietary fat (PMID: 8675642). Since carbs don’t have a storage form, they must be preferentially burned, which reduces fat burning So on a high carb, low fat diet, you don’t burn much fat, but you also don’t store much fat On a low carb, high fat diet, you burn a lot of fat but you also store a lot of fat. What determines overall fat loss or gain will be energy balance, how many calories you consume vs. how many you expend. This is why diets equal in calories & protein, but vary in carb & fat amounts produce equal fat loss in research studies (PMID: 28193517) Get my research review REPS: biolayne.com/REPS Get my new nutrition coaching app, Carbon Diet Coach: http://onelink.to/9h4d62 My research based supplements: http://www.outworknutrition.com Get my books on how to lose fat: http://www.biolaynestore.com Take my online course "The Science of Nutrition": https://chfi.click/laynenorton_online Get Custom Workouts by me for $12.99/month: https://biolayne.com/workout-builder/ http://www.facebook.com/laynenorton http://www.twitter.com/biolayne http://www.instagram.com/biolayne

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RNY Gastric Bypass post-op Meg L. answers the question: "Do you notice people treating you any differently now?" 1 year 4 months post-op RNY Gastric Bypass Peak weight was 350 lbs. Weight at interview: 221 lbs.