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Welcome back to The Visser Podcast! 👋 Today, I’m diving deep into Retatrutide, often called the 'triple G' agonist, and why it's poised to be a game-changer in metabolic health and longevity. We're talking about the next frontier in weight management and beyond. What is Retatrutide? This groundbreaking compound targets three crucial hormones – GLP-1, GIP, and glucagon. This unique multi-hormonal approach has shown truly remarkable results, even surpassing current leading medications like tirzepatide and semaglutide in weight loss efficacy. The Latest Clinical Insights: In its Phase 2 trials, participants saw an average of 24.2% body weight reduction (that’s about 58 lbs!) over 48 weeks. Some even experienced up to 31% loss, which is quite significant and required careful dose management. We're eagerly anticipating more data from the ongoing Phase 3 TRIUMPH program. Look out for results on obesity and OA knee studies coming in 2025, with further insights into obstructive sleep apnea (OSA) and type 2 diabetes expected by mid-2026. Plus, we'll see Phase 2b renal function trial results in Q4 2025. Safety & What We Know So Far: Like many medications in this class, common side effects include nausea and abdominal pain. The rapid weight loss observed means careful dosing is key, with some participants needing to increase caloric intake to stabilize weight. We did see one reported case of kidney stones, though its direct link to the drug is still being investigated. Beyond Weight Loss: The Broader Benefits: What truly excites me are the potential benefits beyond just weight loss. Early data suggests significant improvements in comorbidities like reduced knee pain, better cholesterol levels, and even improved fatty liver disease. There's promising data pointing to liver fat reduction and potential benefits for MASH (metabolic dysfunction-associated steatohepatitis). The Competitive Edge: Retatrutide could really solidify Eli Lilly's leadership in obesity therapeutics, potentially offering a new solution for those who haven't responded to existing therapies. It's an exciting time with new innovations like oral GLP-1 pills and once-yearly shots also in the pipeline. Key Upcoming Milestones: 2025: Phase 3 obesity/OA knee data release. 2026: Full Phase 3 results (TRIUMPH-1/-2) and potential FDA submission. 2027: Head-to-head trial vs. tirzepatide (TRIUMPH-5). This medication represents a significant step forward in our journey toward better health and longevity. I'll keep you updated as more data emerges! Let me know your thoughts and questions in the comments below! 👇 Relevant Studies & Resources: https://doi.org/10.1093/ehjcvp/pvad080 https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=915087 https://sciencehub.novonordisk.com/content/dam/sciencehub/global/en/congresses-and-scientific-publications/congresses/ow2024/Garvey/documents/Garvey_OASIS_4_OW24-oral_Final_23Oct24.pdf https://doi.org/10.1001/jamainternmed.2024.2525 https://investor.lilly.com/news-releases/news-release-details/lillys-tirzepatide-successful-phase-3-study-showing-benefit https://investor.lilly.com/news-releases/news-release-details/lillys-tirzepatide-was-superior-placebo-mash-resolution-and-more https://investor.lilly.com/news-releases/news-release-details/lillys-phase-2-retatrutide-results-published-new-england-journal https://www.boehringer-ingelheim.com/human-health/metabolic-diseases/survodutide-top-line-results-mash-fibrosis https://ir.altimmune.com/news-releases/news-release-details/correction-altimmune-presents-results-phase-2-mri-based-body https://investors.amgen.com/static-files/0176d78e-920b-45b3-b9cc-a727e58e80da https://investor.lilly.com/news-releases/news-release-details/lillys-phase-2-results-published-new-england-journal-medicine https://ir.vikingtherapeutics.com/2024-11-04-Viking-Therapeutics-Reports-New-Data-from-VK2735-Obesity-Program-at-ObesityWeek-R-2024 https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=915082 https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=915251 https://medically.roche.com/global/en/medical-material.3d8d7ba5-5a5d-4b7d-bed7-f4f5e05e5a6e.qr.html?cid https://www.kailera.com/press-release/jiangsu-hengrui-pharmaceuticals-and-kailera-therapeutics-report-positive-topline-data-from-8-mg-dose-of-phase-2-obesity-trial-of-glp-1-gip-receptor-dual-agonist-hrs9531/

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#GLP #thyroidcancer #type2diabetes Does GLP-1 drug affect thyroid cancer risk? A study published in the journal The BMJ found no significant increase in thyroid cancer risk for people with type 2 diabetes on GLP-1 agonists compared with people treated with DPP4 inhibitors. Glucagon-like peptide-1 receptor (GLP-1) agonists are an effective treatment for controlling blood glucose levels in people with type 2 diabetes, particularly those who do not respond, or stop responding to, first-line treatments, such as metformin. One concern about the medications is that some studies suggest they may increase the risk of thyroid cancer. However, these studies point out that the health benefits of the drugs are likely to outweigh this increased risk. The study used data on more than 145,000 people treated with GLP-1 agonists, and almost 292,000 people treated with DPP4 inhibitors. The researchers followed up participants after a mean of 3.9 years for the GLP-1 group and 5.4 years for the DPP4 group. They identified cases of thyroid cancer from nationwide cancer registers. The results revealed that in the GLP-1 group, 76 of 145, 410 people developed thyroid cancer, and in the DPP4 group, 184 of 291, 667 developed the disease. The researchers concluded that the relative risk was increased by no more than 31% for those on GLP-1 agonists. “The meaning of relative risk is the risk compared to someone not taking the medication — 31% is very low and indicates that the risk of developing thyroid cancer due to this medication is relatively low,” said Mir Ali, MD, medical director of Memorial Care Surgical Weight Loss Center. Check full updates on Medical Dialogues Also check out - Medical Dialogues Academy, a renowned academic wing of Medical Dialogues - India's premier health and news online portal, proudly presents this comprehensive course tailored for healthcare professionals eager to delve into the realm of medical journalism. 🔗 Enroll Today: https://academy.medicaldialogues.in/courses/certificate-course-in-medical-journalism/ 📚 Explore More With Us: 📌 Medical Content Writing: https://academy.medicaldialogues.in/courses/medical-content-writing/ 📌 Certificate Course in Pharmaceutical Medico-Marketing: https://academy.medicaldialogues.in/courses/certificate-course-in-pharmaceutical-medico-marketing/ Join us on this enlightening journey and become a part of a community pushing the boundaries of healthcare communication and reporting. Get the latest medical and health news at medicaldialogues.in Follow us on Twitter: https://twitter.com/medicaldialogs Facebook: https://www.facebook.com/medicaldialogues/ Instagram: https://www.instagram.com/medicaldialogues LinkedIn: https://www.linkedin.com/company/medical-dialogues Website: https://medicaldialogues.in/

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Introduction

The ketogenic diet has become increasingly popular over the past few years, attracting individuals who are seeking effective weight-loss solutions. This low-carbohydrate, high-fat eating plan is designed to encourage the body to enter a state of ketosis, where fat is used as the primary source of energy instead of carbohydrates. As more people have turned to the keto lifestyle, the demand for supplements that can enhance and support this diet has surged. One such product that has gained notable attention is Keto IQ. Touted as a potent supplement for anyone following a ketogenic diet, Keto IQ promises to improve mental clarity, energy levels, and overall health by helping the body to achieve and maintain ketosis. However, like any dietary supplement, it is essential to assess its benefits and drawbacks critically to make an informed decision regarding its use.

Keto IQ is often marketed as a nootropic supplement, which means it is designed to enhance cognitive function while supporting the metabolic changes associated with a ketogenic diet. Users are often drawn to its claim of aiding in fat burning, elevating energy levels, and enhancing mood. However, the keto supplement market is rife with products, each claiming to stand out due to unique ingredients or formulations. Thus, it can be overwhelming for consumers to navigate and decide which products truly deliver on their promises.

This article will delve deeply into Keto IQ, exploring its pros and cons to provide potential users with a well-rounded view of what to expect from this supplement. We will examine its ingredients, effectiveness, side effects, and user reviews. By the end, readers should be equipped with the knowledge necessary to determine whether Keto IQ aligns with their health and wellness goals. If you are considering incorporating Keto IQ into your regimen, understanding both its advantages and disadvantages will help you make a choice that benefits both your diet and overall lifestyle.

Understanding the Ingredients

The effectiveness of any supplement largely relies on its ingredients. Keto IQ is formulated with several key components that are designed to support the ketogenic process. Some of its primary ingredients include medium-chain triglycerides (MCTs), which are natural fats that can rapidly convert into energy. Studies have shown that MCTs may help increase ketone levels in the body, thus promoting faster entry into ketosis. This immediate energy source can be particularly beneficial for individuals adhering to a strict keto diet, as it helps to mitigate the fatigue often referred to as the “keto flu.”

Another significant ingredient found in Keto IQ is beta-hydroxybutyrate (BHB). BHB is a type of ketone that provides an alternative energy source for the brain and body when carbohydrates are scarce. Supplementing with BHB can enhance mental focus and concentration, helping users to achieve greater productivity and cognitive clarity. Numerous studies have indicated that BHB supplementation may also help to reduce appetite, which can assist with weight management efforts, making it an appealing option for many on a ketogenic journey.

In addition to MCTs and BHB, Keto IQ often contains a variety of vitamins and minerals that support overall health. These can include Vitamin B6, which is known for its role in energy metabolism, and magnesium, which is crucial for maintaining proper bodily functions in those following a restrictive diet. Together, these ingredients create a synergistic effect aimed at boosting energy levels, supporting cognitive function, and enhancing overall well-being while on a keto diet. However, as with any supplement, it is essential to examine how these ingredients interact with individual health conditions and dietary needs.

The Pros of Keto IQ

Keto IQ boasts several advantages for those following a ketogenic lifestyle. One of the primary benefits is its ability to provide a quick source of energy. Since ketogenic dieters often experience a lag in energy levels as their bodies transition from burning carbohydrates to fats, the inclusion of MCTs and BHB in Keto IQ can help counteract this dip. Users frequently report an increase in energy levels shortly after consumption, which can be especially helpful for those who may struggle with fatigue during the initial stages of ketosis.

Another significant advantage of Keto IQ is its potential impact on mental clarity and cognitive function. Many users have noted improvements in focus and mental performance after taking the supplement. This enhancement can be attributed to the presence of BHB, which serves as an alternative energy source for the brain, making it more efficient during ketosis. As a nootropic supplement, Keto IQ aims to support users in maintaining peak cognitive function, particularly during periods of restricted carbohydrate intake when traditional energy sources may be unavailable.

Keto IQ also appears to be user-friendly in terms of incorporation into daily routines. Available in convenient forms such as capsules or powders, it can easily be mixed into beverages or taken on-the-go, allowing individuals to maintain their supplement regimen without substantial disruption to their lifestyle. This ease of use can be particularly appealing to people who are busy or frequently travel, supporting their commitment to the ketogenic diet regardless of their location.

The Cons of Keto IQ

Despite its benefits, Keto IQ also has some disadvantages that potential users should carefully consider. One of the primary concerns associated with this supplement is the potential for gastrointestinal discomfort. Some users have reported experiencing digestive issues, such as bloating or diarrhea, especially when they are first starting usage or when consuming high doses. This side effect can be particularly troublesome for those who are already navigating a new diet and may be sensitive to changes in their digestive health.

Furthermore, while many individuals may experience positive results with Keto IQ, it is crucial to recognize that not everyone will respond the same way to the supplement. The effectiveness may vary based on individual metabolic rates, dietary habits, and overall health conditions. Users seeking immediate and significant weight loss may find that the supplement alone is not sufficient; it needs to be combined with a well-structured dietary plan and exercise regimen for maximal effectiveness.

Lastly, the cost of Keto IQ can also be a drawback for some. As a dietary supplement, it is an additional expenditure that individuals may not have initially budgeted for when starting their keto journey. While some may view the investment as worthwhile for the potential benefits, others might find it challenging to justify the expense, particularly if they are already purchasing various other supplements or groceries to adhere to their diet.

User Testimonials and Experiences

Real-world experiences from users can provide valuable insights into the effectiveness and practicality of Keto IQ. Many users have shared positive testimonials about the supplement’s role in their keto journey. For some, the quick energy boost and enhanced mental clarity have made a noticeable difference in daily life, aiding in activities ranging from workouts to cognitive tasks at work. Testimonials emphasize how users have been able to maintain their energy and productivity levels throughout the day, combating feelings of fatigue that can accompany the keto diet.

However, not all experiences have been uniformly positive. Some users have reported side effects, including gastrointestinal issues or headaches after starting Keto IQ. These side effects can lead to frustration, especially for those looking for a straightforward supplement to accelerate their weight loss efforts. Additionally, some feedback emphasizes the learning curve involved in understanding how to properly incorporate the supplement into a diet to minimize discomfort while maximizing its benefits.

Importantly, user experiences highlight the need for realistic expectations. Many testimonials discuss that while Keto IQ improved energy levels and cognition, it was not a standalone solution for weight loss. Consistent dietary practices and regular exercise remained critical components of success. Users recommend combining Keto IQ with a balanced keto dietary plan, as well as staying hydrated and listening to the body’s signals to achieve optimal results.

FAQs and Summary

When evaluating any supplement, it is common for potential users to have questions. Frequently, individuals wonder about the safety of Keto IQ. Generally, the supplement is regarded as safe for most healthy adults when taken as directed. However, those with pre-existing medical conditions or individuals taking medications should consult with a healthcare provider before beginning any new supplement regimen. Additionally, pregnant or breastfeeding women are advised to exercise caution and seek medical advice beforehand.

Another common inquiry is related to the expected timeline for results. While some users report an energy boost immediately after consumption, noticeable changes in weight or cognitive performance may take longer, often a few weeks of consistent use. It is essential for users to remain patient and recognize that supplements are meant to enhance an existing diet and lifestyle, rather than serve as quick fixes.

In summary, Keto IQ presents both advantages and disadvantages for those following a ketogenic diet. Its primary benefits include enhanced cognitive function, increased energy levels, and ease of incorporation into daily routines. Conversely, potential gastrointestinal discomfort, varied effectiveness among individuals, and associated costs are key drawbacks to consider. Ultimately, prospective users should engage in thorough research, reflect on their specific health needs, and consult with healthcare professionals to determine if Keto IQ aligns with their wellness journey.

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