Treatment of men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance. In order for Aggra to be effective, sexual stimulation is required. Aggra is also indicated in pulmonary arterial hypertension.
Aggra is a selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). When sexual stimulation causes the local release of nitric oxide; inhibition of PDE5 by Aggra produces increased levels of cGMP in the corpus cavernosum. This results in smooth muscle relaxation and inflow of blood into the penile tissues, thereby producing an erection. Aggra has no effect in the absence of sexual stimulation.
Mechanism of Action: The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by Sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.
Pharmacokinetics and Metabolism: Sildenafil is rapidly absorbed after oral administration, with a mean absolute bioavailability of 41% (range 25-63%). It is eliminated predominantly by hepatic metabolism (mainly cytochrome P450 3A4) and is converted to an active metabolite with properties similar to the parent, Sildenafil. Both Sildenafil and the metabolite have terminal half lives of about 4 hours.
Absorption and Distribution: Sildenafil is rapidly absorbed. Maximum observed plasma concentrations are reached within 30 to 120 minutes (median 60 minutes) of oral dosing in the fasted state. When Sildenafil is taken with a high fat meal, the rate of absorption is reduced.
Metabolism and Excretion: Sildenafil is cleared by hepatic microsomal isoenzymes. After either oral or intravenous administration, Sildenafil is excreted as metabolites predominantly in the feces (approximately 80% of administered oral dose) and to a lesser extent in the urine (approximately 13% of the administered oral dose).
Pharmacokinetics in Special Populations: Geriatrics: Healthy elderly volunteers (65 years or over) had a reduced clearance of Sildenafil, resulting in approximately 84% and 107% higher plasma AUC values of Sildenafil compared to those seen in healthy younger volunteers.
###Pharmacist Ahamadullah ###
###Aggra 100###
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For many men in Canada, erectile dysfunction (ED) can be a difficult and embarrassing issue to deal with. Fortunately, there are various treatment options available on the market, one of which includes blue gummies specifically designed to help with ED. In this article, we will explore the effectiveness of blue gummies for ED in Canada, based on user reviews and availability.
User Reviews of Blue Gummies for ED in Canada
Many men in Canada have turned to blue gummies as a natural and discreet way to address their ED issues. User reviews of blue gummies for ED in Canada have been overwhelmingly positive, with many reporting noticeable improvements in their symptoms after incorporating these supplements into their daily routine.
One user, John from Toronto, praised the effectiveness of blue gummies in helping him maintain a firm erection and improve his overall sexual performance. He noted that the gummies were easy to take and did not cause any adverse side effects.
Another user, Mark from Vancouver, shared a similar experience, stating that blue gummies had significantly boosted his confidence in the bedroom and strengthened his relationship with his partner. He highlighted the convenience of being able to discreetly take the gummies without needing a prescription.
Availability of Blue Gummies for ED in Canada
Blue gummies for ED are readily available in Canada through various online retailers and health stores. These supplements can be purchased without a prescription, making them a convenient option for men seeking a natural remedy for their ED symptoms.
Many users appreciate the accessibility of blue gummies for ED in Canada, as it allows them to discreetly purchase and use the supplements without having to visit a doctor or disclose their condition to anyone else. The widespread availability of these gummies has made it easier for men to take control of their sexual health and improve their quality of life.
Overall, blue gummies for ED have emerged as a popular choice among men in Canada looking for a natural and effective solution to their erectile dysfunction issues. With positive user reviews and easy availability, these supplements have proven to be a viable option for those seeking to enhance their sexual performance and regain confidence in the bedroom.
Summary and Frequently Asked Questions (FAQ) about Blue Gummies for ED in Canada
As we have explored in this article, blue gummies for ED have garnered positive reviews from users in Canada, with many reporting significant improvements in their symptoms and overall sexual performance. These supplements are widely available online and in stores, making them a convenient and discreet option for men seeking to address their ED issues.
Some frequently asked questions about blue gummies for ED in Canada include:
1. Are blue gummies for ED safe to use?
Yes, blue gummies for ED are typically safe to use and are made from natural ingredients. However, it is always recommended to consult with a healthcare professional before starting any new supplement regimen.
2. How long does it take to see results with blue gummies for ED?
Results may vary for each individual, but many users report seeing improvements in their symptoms within a few weeks of consistent use.
3. Can blue gummies for ED be used in conjunction with other ED medications?
It is recommended to consult with a doctor before combining blue gummies with other ED medications to ensure there are no potential interactions or adverse effects.
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