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This is an 18+ Adult Cannabis Channel!!! Welcome to The HotBox🔥 In this video we went to the Aquarium high AF on THC Gummies!! This video was recorded to be a vlog so sorry for us not having enough smoking sessions but we were there for some good times & fish🐟🦈 Make sure to Like & Subscribe for more like this!! Big ideas in mind and want to branch out and have more fun with everyone🙏💯 SUPPORT US!!! Check out our Twitch!!! @TheHotBox710 Link: https://www.twitch.tv/thehotbox710 Follow us on Instagram!! @thehotbox.ig Link: https://www.instagram.com/thehotbox.ig/ Music: (Prod. @WonderlustBeats ) VIDEOS!! Check out our last Vlog Styled Video!! Link: https://youtu.be/O8fHgkIMvog Go watch The HotBox Playlist!! Link: https://www.youtube.com/watch?v=fxxIhUKBJqM&list=PLj-5_TZdkeKKtPsOlww3A1m-iF6zZnKbb #aquarium #edibles #thc THANK YOU EVERYONE FOR ALL THE LOVE THIS YEAR!! BIG THINGS COMING IN 2022!!
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https://www.evopure.co.uk/ The Endocannabinoid System (ECS) plays a significant part in balancing our bodies' most significant functions from rest, to mood, to appetite, to bowel movements, and more. The ECS was discovered in the 1990s when researchers were investigating plant-like atoms, found cannabinoids that were delivered by the human body. The ECS's principal job is to maintain bodily homeostasis and natural amiability in light of ecological changes, for example, physical and mental stress. Science has since discovered that ECS is present in anything with a vertebra. For example, mammals, birds, reptiles, amphibians, and fish. At first, research indicated endocannabinoid receptors were just present in the mind and nerves, but they have since been found all through the whole body including our skin. Today we know that the endocannabinoid framework is engaged with various processes including pain, memory, state of mind, hunger, stress, rest, digestion, immune system, and our conceptive functions. Endocannabinoids are arguably one of the fastest and versatile atoms. The Endocannabinoid System is anything but a basic framework, it's complex, and when in balance, offers wellbeing and joy. Let’s take a look into how CBD interacts with our bodies.
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CBD is one of a class of compounds known as cannabinoids, which are found in the cannabis plant. Unlike THC (the main psychoactive component of cannabis), CBD is not thought to have intoxicating effects. It is, however, believed to interact with the nervous system. In this video, I discuss what we know about CBD’s mechanism of action and its potential in treating various conditions like epilepsy and anxiety. TRANSCRIPT: CBD is one of a class of compounds known as cannabinoids, which are found in the cannabis plant. Unlike THC (the main psychoactive component of cannabis) CBD is not thought to have intoxicating effects. It is, however, believed to interact with the nervous system, which may enable it to modulate the effects of thc as well as have actions of its own. CBD is chemically similar to THC, but it does not have the same mechanism of action, and some evidence suggests it may even interfere with some of the actions of THC. One way it may do this is by binding to receptors that THC binds to known as CB1 receptors, but instead of activating them, causing a change in the receptor that reduces THC’s ability to interact with it. This type of effect is known as negative allosteric modulation, and it may enable CBD to mitigate some of the adverse effects of THC, like anxiety. Other research, however, suggests CBD can enhance certain effects of THC, and CBD is also thought to act at a number of other targets besides the CB1 receptor. For example, CBD is believed to activate serotonin receptors and may increase levels of a natural cannabinoid called anandamide by blocking anandamide reuptake and inhibiting the enzymatic breakdown of anandamide. Overall, although a number of targets for CBD have been identified, its mechanism of action is still poorly understood. CBD is generally well-tolerated, but some have raised concerns about the need for more research before we can be confident about its safety in all populations. CBD, however, is not thought to have potential for abuse, and some believe it does have potential for treating a number of conditions, like anxiety, insomnia, and pain. But most of these claims don’t yet have strong evidence to support them, and more research is needed, although CBD has been found to be a viable treatment for at least some types of epilepsy. REFERENCES: Laprairie RB, Bagher AM, Kelly ME, Denovan-Wright EM. Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor. Br J Pharmacol. 2015;172(20):4790-4805. doi:10.1111/bph.13250 McPartland JM, Duncan M, Di Marzo V, Pertwee RG. Are cannabidiol and Δ(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review. Br J Pharmacol. 2015;172(3):737-753. doi:10.1111/bph.12944 Pisanti S, Malfitano AM, Ciaglia E, et al. Cannabidiol: State of the art and new challenges for therapeutic applications. Pharmacol Ther. 2017;175:133-150. doi:10.1016/j.pharmthera.2017.02.041 World Health Organization (WHO). Cannabidiol (CBD): Pre-Review Report. November 2017. Accessed June 28, 2020. https://www.who.int/medicines/access/controlled-substances/5.2_CBD.pdf Special thanks to Srikar Gade for help with fact-checking this video.
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