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Dr. Friedman provides an important update on compounded GLP-1 medications, including tirzepatide and semaglutide. He discusses their uses, effectiveness, safety concerns, and what patients need to know about compounded versions. Learn how these medications work for weight loss and blood sugar control, potential risks, and differences from FDA-approved versions. Stay informed on the latest guidelines and best practices for using GLP-1 receptor agonists. Whether you're a patient or healthcare provider, this update will help you navigate compounded tirzepatide and semaglutide safely and effectively. Watch now to get Dr. Friedman’s expert insights on these popular medications.
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In this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Jens Juul Holst, a renowned Danish physician and physiologist, to discuss GLP-1, a hormone transforming our understanding of metabolic health. Dr. Holst, who discovered and described GLP-1, explains its role as a gut-derived hormone that regulates appetite, insulin secretion, and digestion, offering a groundbreaking approach to managing obesity and type 2 diabetes.
The conversation explores how GLP-1 receptor agonists, have evolved into powerful medications. These drugs help patients achieve significant weight loss, reverse diabetes, improve cardiovascular health, reduce inflammation, and potentially enhance cognitive function. Dr. Holst delves into their long-term implications for preventing diabetes, extending health spans, and even reducing the risks of obesity-related cancers and improving fertility.
Dr. Holst emphasizes that while GLP-1 offers life-changing benefits, sustainable health still hinges on balanced diets and regular physical activity. This episode provides a fascinating look at the intersection of science, medicine, and lifestyle in promoting longevity.
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View show notes here: https://blog.insidetracker.com/longevity-by-design-podcast-jens-juul-holst
Episode highlights:
Introduction: 00:00:00
What is GLP-1: 00:03:00
what is a GLP-1 agonist: 00:04:15
what are the target organs of the GLP-1 agonist?: 00:06:30
what is the effect of the GLP-1 agonist on a diabetic patient?
: 00:10:00
What percentage of a diabetic patient on GLP-1 have complete remission: 00:11:30
How long did it take to bring a drug to market from the moment you first discovered it: 00:23:30
What is the GLP-1 effect on cognition and dementia: 00:29:00
GLP-1 effect on kidney diseases: 00:32:00
GLP-1 positive effect on fertility: 00:35:00
GLP-1 positive effect on cancer: 00:37:30
Should a patient be on GLP-1 for life: 00:41:00
GLP-1 related side effects: 00:48:00
GLP-1 effect on resting heart rate: 00:52:30
GLP-1 related side effects: 00:48:00
GLP-1 from Lilly vs novo nordisk: 00:55:00
GLP-1 oral versus the injectable: 00:58:00
GLP-1 effect on lifespan: 01:00:30
GLP-1 effect on lifespan: 01:00:30
What led you to become a scientist: 01:03:00
The story of discovering the GLP-1: 01:04:30
How did you successfully extend the half-life of the GLP-1 agonist: 01:09:00
GLP-1 moving from once a day to once a week: 01:16:00
Top tip to improve healthspan: 01:18:00
GLP-1 Agonists: A Game-Changer for Diabetes and Obesity
Dr. Jens Juul Holst explores the revolutionary impact of GLP-1 agonists in treating diabetes and obesity. These medications mimic a natural gut hormone to regulate insulin secretion, appetite, and weight. Through their ability to normalize blood glucose levels and promote significant weight loss, GLP-1 agonists have transformed the lives of patients with type 2 diabetes and obesity. Holst highlights their success in enabling over 50% of diabetes patients to achieve normal glucose levels while addressing the systemic health risks tied to obesity. This innovation represents a monumental leap in metabolic disease management.
Beyond Weight Loss: Cardiovascular and Inflammatory Benefits of GLP-1
Dr. Holst emphasizes the additional health advantages of GLP-1 agonists, beyond their effects on diabetes and obesity. These drugs improve cardiovascular outcomes by reducing major adverse events such as heart attacks and strokes. They also decrease systemic inflammation, a common issue in metabolic diseases. Holst points out that GLP-1 therapy’s dual action on vascular health and inflammation positions it as a comprehensive solution for improving long-term health outcomes in patients with diabetes or obesity.
The Impact of GLP-1 on Fertility
Dr. Holst explores GLP-1’s surprising potential in fertility treatments, particularly for individuals with metabolic-related infertility issues, such as polycystic ovary syndrome (PCOS). He explains that improving metabolism and reducing insulin resistance with GLP-1 therapy can enhance fertility outcomes for both men and women. Although he urges caution due to limited long-term data, Holst notes the promising effects observed in clinical experiences.
“If you can ameliorate the metabolism of these individuals, they will immediately become pregnant. And we knew that already. You can even do it with metformin…Once GLP-1s were introduced, it turned out that yes, these people became pregnant.”
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As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast
For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
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🔥 LIVE: The Truth About GLP-1 Weight Loss! Zepbound, Mounjaro, Ozempic, Wegovy & More 🔥
Welcome to Downsized Live — the raw, unfiltered GLP-1 conversation you’ve been waiting for. We’re Laraine and Christopher Durham, and we’ve lost over 150 pounds using GLP-1 medications for weight loss. If you’re taking or considering medications like Zepbound, Mounjaro, Ozempic, Wegovy, tirzepatide, or semaglutide, this live stream is for YOU.
This week’s episode is all about your most pressing GLP-1 questions. We’re breaking down what works, what doesn’t, and what we wish someone had told us sooner.
✅ We’ll take your questions LIVE
🎉 Celebrate your wins and milestones with the community
🤝 And most importantly, help you build a support system that lasts
Whether you’re just starting your GLP-1 adventure or well into your transformation, this is the support, connection, and honest conversation you’ve been looking for.
👇 Stay connected & explore more:
🛳️ Book your spot on the Downsized at Sea Cruise 2025
https://thedownsized.org/downsized-at-sea-2025/
🛒 Shop GLP-1 Companion Products
https://thedownsized.org/downsized-store/
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https://www.youtube.com/@thedownsized/join
🌐 Visit our website for resources, updates & more:
https://thedownsized.org/
💬 Hit that reminder. Bring your questions. Share your wins. Let’s grow this GLP-1 community—together.
See you live!
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Mitolyn Weight Loss 2025 Review 🔥 | Real Mitochondria Support or Just Overhyped Buzz? (WATCH BEFORE YOU BUY!)
Thinking about trying Mitolyn for weight loss in 2025? 🧬 In this video, we dive deep into what makes Mitolyn stand out and whether it’s truly worth your money—or just another weight loss gimmick.
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Perfect for anyone battling a slow metabolism due to age, chronic stress, or lifestyle habits, Mitolyn supports:
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Made in the USA and available in various package sizes to match your fitness goals.
✅ Does Mitolyn Really Work?
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By revitalizing mitochondrial function, Mitolyn helps your body convert stored fat into usable energy more effectively—especially important as we age.
✅ Are There Any Side Effects?
Mitolyn is made with natural ingredients and is generally safe for most users. Mild side effects can include:
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Always consult a healthcare provider before starting any supplement, especially if pregnant, nursing, or on medication.
🟢 Final Verdict: Hype or Health Game-Changer?
Mitolyn isn’t a magic pill, but it is a science-backed formula that supports real, lasting weight loss—especially when combined with a healthy lifestyle. For those looking to improve mitochondrial health, metabolism, and overall energy, Mitolyn may be a game-changer in 2025.
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Burn a few extra calories with this faster flowing yoga sequence that is designed to keep your heart rate more elevated than more traditionally slower paced yoga practices. Target the muscles in your arms, abs, butt, hips, thighs (and even your shoulders, back, chest, calves and feet too!) with this at home, non stop yoga inspired workout that requires minimal space and equipment to complete.
Plank positions are used in this series so if you have wrist issues, please be sure to modify or skip any exercises that cause you pain or discomfort (check out our "how to modify push ups" video for ideas: http://bit.ly/1OLIIOu).
Level: Intermediate (best for those with prior yoga experience)
Equipment: A mat is recommended (though not required)
Intensity: Low to Moderate, Low Impact
Did you try the workout? Leave me a comment below and tell me your favorite move!
