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Welcome back to The Visser Podcast! 👋 Today, I’m diving deep into Retatrutide, often called the 'triple G' agonist, and why it's poised to be a game-changer in metabolic health and longevity. We're talking about the next frontier in weight management and beyond. What is Retatrutide? This groundbreaking compound targets three crucial hormones – GLP-1, GIP, and glucagon. This unique multi-hormonal approach has shown truly remarkable results, even surpassing current leading medications like tirzepatide and semaglutide in weight loss efficacy. The Latest Clinical Insights: In its Phase 2 trials, participants saw an average of 24.2% body weight reduction (that’s about 58 lbs!) over 48 weeks. Some even experienced up to 31% loss, which is quite significant and required careful dose management. We're eagerly anticipating more data from the ongoing Phase 3 TRIUMPH program. Look out for results on obesity and OA knee studies coming in 2025, with further insights into obstructive sleep apnea (OSA) and type 2 diabetes expected by mid-2026. Plus, we'll see Phase 2b renal function trial results in Q4 2025. Safety & What We Know So Far: Like many medications in this class, common side effects include nausea and abdominal pain. The rapid weight loss observed means careful dosing is key, with some participants needing to increase caloric intake to stabilize weight. We did see one reported case of kidney stones, though its direct link to the drug is still being investigated. Beyond Weight Loss: The Broader Benefits: What truly excites me are the potential benefits beyond just weight loss. Early data suggests significant improvements in comorbidities like reduced knee pain, better cholesterol levels, and even improved fatty liver disease. There's promising data pointing to liver fat reduction and potential benefits for MASH (metabolic dysfunction-associated steatohepatitis). The Competitive Edge: Retatrutide could really solidify Eli Lilly's leadership in obesity therapeutics, potentially offering a new solution for those who haven't responded to existing therapies. It's an exciting time with new innovations like oral GLP-1 pills and once-yearly shots also in the pipeline. Key Upcoming Milestones: 2025: Phase 3 obesity/OA knee data release. 2026: Full Phase 3 results (TRIUMPH-1/-2) and potential FDA submission. 2027: Head-to-head trial vs. tirzepatide (TRIUMPH-5). This medication represents a significant step forward in our journey toward better health and longevity. I'll keep you updated as more data emerges! Let me know your thoughts and questions in the comments below! 👇 Relevant Studies & Resources: https://doi.org/10.1093/ehjcvp/pvad080 https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=915087 https://sciencehub.novonordisk.com/content/dam/sciencehub/global/en/congresses-and-scientific-publications/congresses/ow2024/Garvey/documents/Garvey_OASIS_4_OW24-oral_Final_23Oct24.pdf https://doi.org/10.1001/jamainternmed.2024.2525 https://investor.lilly.com/news-releases/news-release-details/lillys-tirzepatide-successful-phase-3-study-showing-benefit https://investor.lilly.com/news-releases/news-release-details/lillys-tirzepatide-was-superior-placebo-mash-resolution-and-more https://investor.lilly.com/news-releases/news-release-details/lillys-phase-2-retatrutide-results-published-new-england-journal https://www.boehringer-ingelheim.com/human-health/metabolic-diseases/survodutide-top-line-results-mash-fibrosis https://ir.altimmune.com/news-releases/news-release-details/correction-altimmune-presents-results-phase-2-mri-based-body https://investors.amgen.com/static-files/0176d78e-920b-45b3-b9cc-a727e58e80da https://investor.lilly.com/news-releases/news-release-details/lillys-phase-2-results-published-new-england-journal-medicine https://ir.vikingtherapeutics.com/2024-11-04-Viking-Therapeutics-Reports-New-Data-from-VK2735-Obesity-Program-at-ObesityWeek-R-2024 https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=915082 https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=915251 https://medically.roche.com/global/en/medical-material.3d8d7ba5-5a5d-4b7d-bed7-f4f5e05e5a6e.qr.html?cid https://www.kailera.com/press-release/jiangsu-hengrui-pharmaceuticals-and-kailera-therapeutics-report-positive-topline-data-from-8-mg-dose-of-phase-2-obesity-trial-of-glp-1-gip-receptor-dual-agonist-hrs9531/
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🔥 Java Burn Reviews: Is It Worth the Hype? Are you struggling with weight loss and looking for a natural way to boost your metabolism? ⚡ Java Burn claims to help by enhancing fat burning and increasing energy levels. But does it really work? Let’s break it down! 👇 🤔 What is Java Burn? Java Burn is a tasteless powdered supplement designed to mix with coffee ☕. It contains natural ingredients like green tea extract 🍵, chromium, and L-theanine, which may help improve metabolism and support fat loss. ✅ How Does Java Burn Work? 🔥 Boosts metabolism – Helps your body burn more calories. ⚡ Increases energy – Keeps you active throughout the day. 🔥 Supports fat oxidation – Aids in breaking down stored fat. 🍽️ Reduces cravings – May help control appetite and prevent overeating. 📝 Key Ingredients 🍵 Green Tea Extract – Rich in antioxidants, helps burn fat. 🧂 Chromium – May regulate blood sugar and curb cravings. 🧘 L-Theanine – Promotes focus and reduces caffeine jitters. 🌿 Ginger & Cinnamon – Support digestion and metabolism. 💡 How to Use Java Burn? Mix one packet with your morning coffee ☕ for the best results. Consistency, along with a healthy diet and exercise 🏋️♂️, can improve outcomes. ⭐ Final Thoughts Java Burn might be a good addition for those looking to support their weight loss journey naturally. However, results may vary. Have you tried it? Share your thoughts in the comments! 👇💬 🚀 Link to the Official Website👉: https://shorturl.at/8t8Jb #javaburn #javaburnreview #javaburncoffee #weightloss #supplementreview #metabolismboost #healthsupplements Disclaimer: This video is for informational purposes only and is not intended as medical advice. Always consult with a healthcare professional before starting any new supplement.
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Get our Fit Father 30-Day Fat Loss Program here → https://www.fitfatherproject.com/youtube-ff30x-program Get our Fit Father Old School Muscle Building Program here → https://www.fitfatherproject.com/youtube-osm-program Subscribe to our channel here → https://goo.gl/wxghQ5 Our free resources: 1-Day Weight Loss Meal Plan → https://www.fitfatherproject.com/youtube-1-dmp-optin 24-Min Fat Burning Workout → https://www.fitfatherproject.com/youtube-24-min-optin 5 Best Muscle Building Exercises → https://www.fitfatherproject.com/youtube-5-muscle-builder-optin When it comes to finding a weight loss diet plan for men, you want the best, right? In this video, I dive into 10 key principles that make a weight loss diet for men effective, simple, and sustainable. If it is all of these things, you can be sure it’s the best and will help you achieve your weight loss results. *#1 - Which Diet Is Best? If you’ve heard of all the different types of diet out there, like Paleo, Low-Carb, Vegan or Vegetarian, or the Caveman Diet, you want to know which one to follow. Essentially, you want to follow a diet that isn’t restrictive, if you want to follow it long term. Your diet should be balanced with all the macronutrients (Protein, Carbs, and Fat), along with vegetables. *#2 - Build 'Perfect Plates' Following on from principle #1, you should use the balanced approach of ALL the macronutrients to prepare ‘perfect plates’, which is a guide to how you should portion these. A ‘perfect plate’ is simply ¼ plate Protein, ¼ plate of Carbs, ½ plate Vegetables, and a small serving of healthy fats. *#3 - The 4 x 4 Meal Timing Strategy This strategy basically means that you should have 4 meals per day, spaced 4 hours apart. This could be breakfast at 8am, Lunch at 12pm, Snack at 4pm, and Dinner at 8pm. This setup helps to keep your blood sugar stable, helping to control cravings and keeps your metabolism high the whole day too. This, paired with the ‘perfect plates’ also controls your calorie intake without you needing to count calories. *#4 - Eat a low-carb breakfast This is the only small tweak to the ‘perfect plates’ principle, which is for breakfast you should eat a low-carb meal. This helps kick-start your metabolism at the beginning of the day and helps hormone levels that let you know you’re satiated. Protein and healthy fats do this much better than carbs, so you’ll feel full until your next meal. *#5 - Pick your 3 "Go-To Foods" Picking your ‘go-to’ foods is basically the easiest way to ensure consistency when following a weight loss diet plan for men over 40. This is simply picking your favorite foods within each of the macronutrient categories. *#6 - Plan one free meal each week Another approach that makes this the best weight loss diet plan is allowing yourself 1 pre-planned meal each week that is a free meal. You don’t need to follow the perfect plates principle or worry about what macronutrients it contains. This one small indulgence each week will keep your diet plan sustainable over the long term. *#7 - Hit your ideal water target When you’re following a weight loss diet for men over 40, you need to consider hydration as well as food intake, so you should set a target of around 100–150 oz of water each day. Water keeps you full, and it keeps your metabolism going by keeping your liver clear to metabolize fat. *#8 - Time calories around workouts This is a great tip that you don’t often hear, but timing your calories around workouts means eating your meal after your workout. For example, if you work out in the morning, do so fasted, then eat breakfast. If you train in the evening, have your dinner straight afterward. Timing your free meal for after a workout is great advice too. *#9 - Track your weight & adjust portions Tracking your weight at least twice per week is beneficial to keep an eye on how your weight loss diet plan for men is working. If you weigh yourself Thursday and Sunday, for example, you’ll be able to see trends that occur around any changes or deviations you’ve made throughout the week. It also offers positive feedback loops as you see progress. *#10 - Eat more Cholesterol Eating more cholesterol can sound a bit counter-intuitive, but cholesterol-rich foods like eggs will help balance your cholesterol levels as well as testosterone levels, which is super important as a man over 40, looking to lose weight. Wishing you every success on your journey. Your friends here at the FFP, -Dr. Balduzzi + The Men's Health Experts @ The Fit Father Project **Disclaimer: This information is for reference purposes ONLY and cannot replace personal information you can and should discuss with your Doctor. If you have any concerns about your health, you should see your Doctor immediately. Results vary by individual, so we do not guarantee you will get the same results as any shown here or on our website.
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Four steps to how I lost some of this belly fat! Also, make sure you mostly eat Whole Foods. Processed everything now and then. You can see some of what I was eating, starting back in June, on my page. "What I Ate" videos Watch: How to Lose Fat | Women Over 40 | Before/After Pics | How to Use Cronometer | High Raw Plant Based https://youtu.be/3zCwNsXoRCI?si=ArCp2khJTTgG12mA Watch this. My fat loss journey from June to November in menopause https://youtu.be/kWdOYCIbrik?si=xE2GMEUig9vh4ujK Watch: Vegan Meal Plan For Fat Loss | What I Took for Work | High Raw Plant Based Lifestyle! 12/8/24 https://youtu.be/F_iE-cgmjfs?si=1CzEHXaRVx6ucCd6 How to Eat Raw Plant Based at Work! https://youtu.be/eGqSKOqox-s?si=zN_9zFN-eS2jm_IE What I Ate High Raw Plant Based | Tried Chickpea Salad For The First Time! https://youtu.be/i0zfe1kIvkI?si=LZqEyxBZMQvE2rzA Check out my video everything I ate and did in LA for my 50th birthday https://youtu.be/0Tf28Cja_yQ?si=2vRUsD6TCSsHA_HZ thank you for watching! Please like, comment and let me know you're watching, and subscribe. And, please follow my Instagram pages! plant-based page https://www.instagram.com/plantbasednicolershae/ lifestyle page https://www.instagram.com/nicolershaeholiday/ Tiktok @plantbasedNicolershae Cash app $Nicolershaeholiday #menopausefatLoss #menopauseweightLoss #menopauseweightlossbeforeandafter #weightlossbeforeandafter #healthyveganeating #youtuber #Contentcreator #highrawplantbased #13yearsplantbased #plantbasedliving #plantbaseddiet #plantbasedeating #blackplantbased #blackplantbaseddiet #plantbaseddiet #plantbasednicolershae #vegandiet #veganeats #veganeating #blackvegans #blackvegan #blackvegansofig #Highrawvegan #highrawvegandiet #blackveganofig #vegan #vegans #blackveganwomen
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WOW! This ride will leave you feeling alive and unstoppable!! This ride is INTENSE! Heart rate will be pumping legs will be shaking, and fat will be burning! In 30 minutes we will focus on heavy training to improve your overall power and endurance on the bike and in life! This ride will not only increase your physical strength but also your mental strength! The intensity of this ride will activate that after-burn and keep your metabolism up after the ride! IMPORTANT to note! Listen to your body during this ride and take extra recovery or decrease resistance or speed if needed! BONUS CHALLENGE!!! If you want to work on improving your stamina and strength even more, every time we hit a 10, add just a little more resistance! If you have any questions about resistance, scroll down just a bit further in this description to get the full explanation! IMPORTANT! The RPMs noted throughout the ride are just a range! Make sure to ride where you feel comfortable! That may be above or below the range indicated. 🇮🇸 We're hosting a trip to ICELAND in JUNE 2024! Reserve your spot here! 👉 https://www.trovatrip.com/trip/europe/iceland/iceland-with-kaleigh-cohen-jun-2024 Check out what's included and the itinerary above! 👆 Spots are limited | ONLY 15 SPOTS AVAILABLE! The first 10 people to sign up get an early bird rate and SAVE $100! Payment plan options are available! Need a longer WARM-UP? https://youtu.be/tOjKOmtPcqs MY LINKS: Looking for indoor cycling shoes?- https://ride.shimano.com/KCF15 Amazon Storefront- https://www.amazon.com/shop/kaleighcohenfitness Like to know about my outfit?- https://amzn.to/41ZammW Become a member here- https://www.buymeacoffee.com/kaleighcohen KCF merch- https://kaleighcohen.com/shop/ Spotify playlist- https://open.spotify.com/playlist/0kJwgXCBhpSbfNMvel0Yku?si=2fe093b636f74e6d Instagram- https://www.instagram.com/kaleighacohen/ Facebook- https://www.facebook.com/kaleighcohenfitness ADD IT: ENCORE!- https://youtu.be/CSJm2ThlAOc DESSERT!- https://youtu.be/eumN5TrtnzI RESISTANCE for my classes You always want to feel something under your feet, this will ensure you are doing the work, prevent you from bouncing in the saddle, and protect your knees! 6 - Working your way up that hill | Moderately Light 7 - Mid-hill already, you can definitely feel this! | Medium 8 - This is where heavy really starts to kick in | Moderately Heavy 9 - We are really starting to climb now! This is a challenging resistance! | Heavy 10 - Top of your hill! You should be able to keep a smooth pedal stroke. | VERY Heavy Watch this for more detail: https://youtu.be/8DbpBXGAB8Q POSITIONS for my classes 1st position: Seated position. 2nd position: Standing with hands at the front of handlebars, also called jogs. 3rd position: Standing with hands at the end of handlebars, also called climbs. Over the Saddle: 3rd position, hips shifted back slightly and chest over the front of the handlebars. Jumps: seated to 2nd position. Freezes: 2nd position, minimizing upper body up and down movement. Leaps: seated to 3rd position. The Trio: seated, 2nd, 3rd, 2nd, seated position. Switchbacks: 3rd to 2nd position. Tick Tocks: 3rd to over the saddle. MODIFICATIONS for seated options 2nd position jogs and moves: Stay seated and increase speed a bit, really focus on the pull-up to activate the quadriceps. 3rd position climbs and moves: Stay in the saddle and increase resistance a smidge, really focus on the push-down and pull-up of the pedal stroke to activate the glutes, hamstrings, and quadriceps maximizing power with the heavy resistance. CHAPTERS: 0:00 - 2:42 WARM UP | Let's Go by The Prizefighter 2:43 - 6:46 ROLLING HILLS | The Throne by Heyson 6:47 - 9:59 JUMPS/FREEZES | I Ain't Afraid to Get Dirty by enemyrun 10:00 - 12:46 ROLLING HILLS | HEIST MUSIC by NIGHTCAP 12:47 - 14:47 SEATED CLIMBS | Tik Tik by Graffiti Ghosts 14:48 - 17:28 INVERTED SPRINTS | Let's Get to Work by Hotline 17:29 - 21:19 JUMPS | FEARLESS (feat WOLVES) by Kairo 21:20 - 25:47 ROLLING HILLS | My Mind by NM 25:48 - 29:34 CLIMBS | Legacy by Kirsten Collins 29:35 - 32:05 COOL DOWN | Back to Your Love by Hector Gabriel Some of the links listed above are affiliate links, such as Amazon, and if you make a purchase through the link, I may make a small commission, this is totally free for you, but really does help support these workouts for you! Thank you in advance, it is very much appreciated! _________________________________________________________________________________________________ 🔴 DISCLAIMER 🔴 When beginning any fitness workout or regimen, it is important to consult your physician to ensure this program is right for you. Do not start this program if your healthcare provider advises otherwise. Any exercises or information on this channel, through videos or comments, is to be used at your own risk. Kaleigh Cohen Fitness will not be responsible or liable for the harm, damage, or injury as a result of any information provided. MB01CPYIIF24FH0
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