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My guest is Dr. Herman Pontzer, Ph.D., a professor of evolutionary anthropology and global health at Duke University, known for his research on human bioenergetics, particularly energy expenditure and the exercise paradox. We discuss his work comparing highly active hunter-gatherer groups to more sedentary cultures, exploring their total energy expenditure and the surprising similarities. We examine the impact of factors such as age, sex, exercise, and pregnancy on daily energy expenditure. We also break down whether diet or exercise plays a greater role in weight management and weight loss. Additionally, we explore how genetics and the environment interact to shape human physiology, highlighting how population-level findings often overlook individual variation and emphasizing the need for medical and diagnostic practices to account for this diversity. Read the full episode show notes: https://go.performpodcast.com/FAtfelj *Thank you to our sponsors* AG1: https://drinkag1.com/perform David Protein: https://davidprotein.com/perform LMNT: https://drinklmnt.com/perform Renaisance Periodization: https://rpstrength.com/perform Eight Sleep: https://www.eightsleep.com/perform *Timestamps* 00:00:00 Dr. Herman Pontzer 00:01:18 Energy Expenditure & Metabolism 00:03:59 Hunter-Gatherers, Energy Expenditure vs Sedentary Cultures 00:07:19 What is Energy Expenditure?; Maintaining Energy Budget 00:13:42 Sponsors: David Protein & LMNT 00:16:23 Weight Gain; Calories In, Calories Out 00:22:18 Exercise & Calories Burned, Energy Expenditure Changes? 00:29:56 Movement Efficiency, Exercise & Metabolism Research 00:37:55 Metabolic Recalibration & Exercise Threshold 00:43:33 Hunter-Gatherer Groups, Energy Expenditure, Fertility 00:47:23 Sponsors: AG1 & Renaissance Periodization 00:49:53 Pregnancy & Energy; Overtraining, Relative Energy Deficiency Syndrome (REDs) 00:57:37 Metabolism “Slowing Down”, Age or Sex Differences? 01:04:22 Metabolism & Age, Puberty, Older Adults 01:11:51 Body Composition, Individual Food Intake 01:16:49 Sponsor: Eight Sleep 01:18:12 Anthropology, Natural Fallacy, Diversity & Adaptations, Physical Activity 01:27:59 Population, Individual Variation, Diversity, Race 01:34:33 Kidney, eGFR Calculation; Clinical Equations & Race 01:40:51 Genetics, Diversity, Populations; Genetic Testing 01:49:29 One-to-One Gene Fallacy, Height, Environment, Diversity 01:51:20 Height & Weight, Genetics & Environment Interplay 01:56:31 Science Literacy & Research; Diabetes, Heart Disease & Race 02:02:33 Diversity, Physiology & Medicine, EMT 02:07:08 Upcoming Projects, Metabolic Ceilings 02:09:39 Metabolism, Diet & Exercise, Individual Approach 02:14:57 Crash Metabolism?, Herman’s Links 02:17:30 Zero-Cost Support, YouTube, Spotify & Apple Subscribe & Reviews, Sponsors, YouTube Feedback, Social Media, Perform Newsletter #science #health #caloriedeficit #weightloss Disclaimer & Disclosures: https://performpodcast.com/disclaimer-disclosures

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📢 GLP-1 Medications – April 2025 Legal Update from Lengea Law 🚨 If your wellness clinic or med spa is offering (or planning to offer) GLP-1 medications like Ozempic, Wegovy, Mounjaro, or compounded semaglutide/tirzepatide, this legal update is a must-watch. The regulatory landscape is changing fast, and staying compliant is critical. In this video, we break down everything you need to know from a legal and compliance perspective. 🔍 What You’ll Learn: • 🆕 Recent FDA Actions & Legal Developments • ⚖️ Current Legal Status of Compounded GLP-1s • 📄 Consent & Disclosure Requirements • 👩‍⚕️ Scope of Practice: Who Can Prescribe & Administer • 🚫 Legal Risks of Off-Label Marketing & Delegation • ✅ How to Stay Compliant in 2025 and Beyond 💬 Have legal questions about offering GLP-1s in your practice? Visit us at LengeaLaw.com or send us a message to schedule a compliance consultation. 📅 Follow for more updates on medical spa regulations, healthcare law, and aesthetic compliance. #GLP1 #Ozempic #Wegovy #Mounjaro #Semaglutide #Tirzepatide #CompoundingLaw #HealthcareCompliance #MedSpaLaw #LengeaLaw #WellnessClinic #MedicalAesthetics #FDARegulations #LegalUpdate

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Do I Need A Prescription For Weight Loss Medication? In this informative video, we’ll discuss the important topic of weight loss medications and the requirements for obtaining them. Weight management is a significant concern for many, and understanding the role of medications in this process can help you make informed choices. We’ll cover the criteria for qualifying for weight loss medications, including the necessary Body Mass Index (BMI) thresholds and the health conditions that may influence eligibility. Additionally, we’ll highlight the essential role healthcare professionals play in assessing individual health needs and determining the appropriate course of action. Lifestyle changes, such as improved nutrition and regular exercise, are key components of any weight management plan. We’ll also touch on the importance of a thorough health assessment before any medication is prescribed, including medical history and physical examinations. It’s vital to recognize that medications should complement a healthy lifestyle rather than replace it. Understanding local regulations regarding prescriptions is also important, as these can vary by location. Join us as we unpack these topics and provide guidance on navigating weight loss medications effectively. Don't forget to subscribe for more helpful information on health and wellness! ⬇️ Subscribe to our channel for more valuable insights. 🔗Subscribe: https://www.youtube.com/@ObesityFightersClub/?sub_confirmation=1 #WeightLoss #WeightManagement #Obesity #HealthyLiving #Nutrition #Exercise #Healthcare #BMI #WeightLossJourney #LifestyleChanges #HealthAssessment #Medication #Diet #Fitness #HealthTips #Wellness About Us: Welcome to Obesity Fighters Club! Our channel is dedicated to helping you achieve your weight loss goals and embrace a healthier lifestyle. We cover a variety of topics, including effective weight loss tips, healthy eating habits, and fitness motivation tailored for all levels. Whether you're seeking fat-burning workouts or meal planning strategies for sustainable weight loss, we’ve got you covered.The content provided is for general, informational, and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

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