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Investigation on the Effects of GLP1 analog and SGLT2 inhibitor against Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms
Background: The present study investigated the possible cardioprotective effects of GLP1 and SGLT2i against diabetic cardiomyopathy (DCM) in type 2 diabetic rats and the possible underlying mechanisms. DCM is defined as the presence of heart failure in absence of coronary artery disease.
Methods: Thirty-two male Sprague Dawley rats were randomly subdivided into 4 equal groups; a) control group, b) DM group, type 2 diabetic rats with saline daily for 4 weeks, c) DM+ GLP1, as DM group with GLP1 analogue (liraglutide) at a dose of 75 µg/kg for 4 weeks, and d) DM+ SGLT2i: as DM group with SGLT2 inhibitor (dapagliflozin) at a dose of 1mg/kg for 4 weeks. By the end of treatment (4 weeks), serum blood glucose, HOMA-IR, insulin and cardiac enzymes (LDH, CK-MB) were measured. Also, the cardiac histopathology, myocardial oxidative stress markers (MDA, GSH and CAT) and norepinephrine (NE), myocardial fibrosis, the expression of caspase-3, TGF-, TNF- and tyrosine hydroxylase (TH) in myocardial tissues were measured. Results: T2DM caused significant increase in serum glucose, HOMA-IR, serum CK-MB and LDH (p less than 0.05). Also, DM caused significant myocardial damage and fibrosis, elevation of myocardial MDA, NE with upregulation of myocardial caspase-3, TNF-, TGF- and TH and significant decrease in serum insulin and myocardial GSH and CAT (p less than 0.05). Administration of either GLP1 analog and SGLT2i caused in significant improvement in all studied parameters (p less than 0.05). Conclusion: We concluded that either of GLP1 and SGLT2i exhibited cardioprotective effects against DCM in T2DM with the upper hand for SGLT2i. This might be due to attenuation of fibrosis, oxidative stress, apoptosis (caspase-3), sympathetic nerve activity and inflammatory cytokines (TNF- and TGF-).
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In today's video I am going to be talking about if you should do cardio before or after weight training. This question is most often asked by people looking to get the most amount of fat burn out of their cardio program. Obviously we would like to do that without sacrificing precious muscle mass.
Since we're trying to get to the bottom of the most effective way to time our cardio program. We want to make sure that doing the cardio is actually burning fat. Doing the cardio before your workout, unless you're working out on an empty stomach, is going to burn a mix of carbs and dietary fat. That means that you're essentially going to be burning what you ate earlier that day during your cardio workout not fat. In fact it'll probably take you a full half hour to just start burning body fat especially with steady state cardio.
The other downside to doing cardio before a workout is also related to the fact that we're going to be burning the food we ate instead of fat. The food we ate, and the stored glycogen from previous meals was going to be valuable fuel for a beast mode workout. All I got to say is good luck with those squats after an hour of running.
You're probably already thinking that cardio after the workout is the only way to go, but I haven't even mentioned the biggest benefit to doing it after rather than before. You see when you're doing cardio usually your goal is to burn body fat, and glycogen is like brick wall between you and you're goal. Imagine that there's a very busy highway and every car on this highway represents glycogen. There's a cross street with a yield sign where cars are trying make a turn and get onto this highway. These cars represent your fat cells. While all the glycogen "cars" are zooming by the fat cell "cars" are just sitting there at the stop sign waiting their turn. Occasionally a fat cell "car" gets through, but for the most part when the glycogen cars are around the fat's not getting through.Finally once there are no more glycogen cars the fat cell cars start going through one after the other at a much faster rate.
What all that means is that your body, which in this case is the highway prefers to use glycogen for energy. Meaning if you do cardio before your weight training you're probably going to be using mostly glycogen to supply the energy. Fat cells on the other hand will be at the "stop sign" and will get used here and there at a low rate. Once all the glycogen is gone that's when we start burning fat at a faster rate. Well how the heck do we get rid of all that glycogen?
Glycogen happens to be the body's go to fuel when lifting weights, and whats even more awesome is that when you weight train glycogen is converted used for energy in mass quantities. So you're going to burn right through that glycogen quick. After an hour or so of intense weight training you will have probably depleted the majority of the glycogen in your body. This means that directly after the weight training would be an ideal time to start cardio because now you're body will have no choice but to burn fat at a higher rate.
If you still only want to do cardio before you're workout then just understand that your going to run into a couple roadblocks. The major one is that your strength and energy levels are going to be depleted if you do a full out cardio session. The only time to do cardio before a workout is as a warm up at a low intensity. You don't really need longer than 10 or 15 minutes to warm up.
Whether you do a HIIT workout or a steady state cardio workout you're still going to burn more fat after weights because you'll be in a glycogen depleted state. I prefer a HIIT workout because you can usually get the same if not better results than steady state cardio in half the time. An example of steady state cardio would be jogging on a treadmill, where as an example of HIIT cardio would be sprinting or boxing at a high intensity. Again you'll burn more fat doing either one directly after weights, but I just prefer HIIT, it saves time.
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Trisha Yearwood Gummies For Weight Loss Celebrityendorsed Health Solutions
Rebel Wilson has been popular for her infectious character and funny acts in movies for years. However, she now inspires numerous people because she started losing weight, and it was effective. Clearly, usage of the weight loss gummies is an area that seems to have attracted a lot of interest from many. Consequently, these gummies have brought up significant buzzes in health and wellness circles with many wondering how Rebel Wilson’s weight loss became successful.
Insight into Rebel Wilson’s Weight Loss Gummies
There is no doubt that Rebel Wilson’s transformation journey through weight loss has been exceptional but how instrumental were ‘weight loss gummies’? Gummies referred here are supplements mainly recommended for weight reduction by decreasing hunger cravings; increasing body metabolism levels as well as providing more energy. As a means to losing some added pounds naturally without complications, Rebel stated that she resorted to this product.
Most times, weight-loss gummy vitamins are made containing natural components such as green tea extract, Garcinia Cambogia, and raspberry ketones among others which have unique fat burning properties. These elements work together targeting cravings suppression; fat burning alongside boosting of energy levels thereby making it easier for individuals who follow healthy diet plans and occasionally do exercises with ease. For Rebel Wilson might be these were a game changer on her journey towards losing excess fats.
Why Choose Weight Loss Gummies?
Weight loss can be done through using slimming gummy vitamins among other methods. What makes this method superior to the rest? Their convenience is one thing that gives them an upper hand over other forms – you can grab some and go or take them on trips when you cannot swallow pills easily. Additionally, these natural ingredients found in most brands are not associated with harmful side effects hence could act as a safer way to enhance fat reduction.
Moreover, such products often contain important antioxidants plus essential minerals designed to boost your entire health system. Such additional benefits will make one feel more motivated, focused as well as energized towards making healthier choices. In the case of Rebel Wilson, this combination of a weight loss aid and general fitness bonuses might have amounted to her victory story.
How to Add Weight Loss Gummies to Your Routine
For those interested in losing weight like Rebel Wilson and considering trying out weight loss gummies, it is crucial that they should engage in some research. Moreover, bear in mind that these are no miracle workers but just a part of maintaining an even diet and doing exercise as well.
When you take on weight loss gummies though you must be sure about when and how much will it be right for your body. As such candies may significantly assist you in shedding off some pounds, however the long-term outcomes will only come through sticking to a healthy lifestyle instead. Like Rebel Wilson’s holistic approach to good health using these gummies goes a long way in helping you achieve your desired body mass.
FAQs: All You Need To Know About Rebel Wilson’s Weight Loss Gummy-Bears
1.Does rebel wilson’s fat burner bears work?
Weight reduction gummies are a useful aid in maintaining weight loss, but they work best when used along with a healthy eating plan and an exercise regimen.
2. Are slimming gummies safe to use?
But, it’s always better seek advice from a medical professional before incorporating any new supplements into your daily routine since natural Weight Loss Gummies are normally safe for many folks.
3. How long does it take to see results from weight loss gummies?
How quickly the effects of weight loss gummies can be seen depends on factors such as metabolism, diet and physical activity that differ from individual to individual. You need to keep consistent and be patient within the routine to get the best results.
4. Can anyone use weight loss gummies?
In case you have some worries or pre-existing conditions, it is essential to check out the ingredients list and speak with your healthcare advisor before using such products even though most people will find them fairly innocuous.
5. How did Rebel Wilson incorporate weight loss gummies into her routine?
According to reports, Rebel Wilson used these supplements for body weight management added in her food programs and regular activities mixed with Weight Loss Gummy Bears which she took every day made her achieve desired health outcomes.
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Are you looking for a way to support your ketogenic lifestyle with a delicious and convenient option? Fit Science Keto Gummies may be the answer you’ve been searching for. These gummies are designed to help boost your ketosis levels, making it easier for you to stay in fat-burning mode. But are they truly effective? In this scientific review, we will take a closer look at Fit Science Keto Gummies and examine their potential benefits for ketosis support.
What Are Fit Science Keto Gummies?
Fit Science Keto Gummies are a dietary supplement that aims to support ketosis, the metabolic state in which your body burns fat for energy instead of carbohydrates. These gummies are formulated with a blend of exogenous ketones, which are designed to help increase the levels of ketones in your blood. By doing so, they may help you achieve and maintain the state of ketosis more easily.
Each serving of Fit Science Keto Gummies contains a precise combination of key ingredients that are intended to work synergistically to support your ketogenic lifestyle. These ingredients may include beta-hydroxybutyrate (BHB) salts, medium-chain triglycerides (MCTs), and other natural compounds that are known to promote ketosis and enhance energy levels.
Fit Science Keto Gummies are intended to be taken as a dietary supplement to complement your ketogenic diet. They are not meant to replace healthy eating habits or regular exercise. Instead, they are designed to provide additional support for your body as you strive to achieve and maintain ketosis.
The Science Behind Fit Science Keto Gummies
The key ingredient in Fit Science Keto Gummies is beta-hydroxybutyrate (BHB), a type of ketone body that is naturally produced in the liver during periods of fasting or carbohydrate restriction. BHB is a crucial component of the ketosis process, as it is used by the body as an alternative fuel source when glucose levels are low.
By supplementing with exogenous ketones like BHB, you may be able to increase the levels of ketones in your bloodstream, which can help induce and sustain ketosis more effectively. This, in turn, may lead to enhanced fat burning, improved energy levels, and other benefits associated with the ketogenic diet.
Additionally, Fit Science Keto Gummies may also contain other ingredients like medium-chain triglycerides (MCTs), which are a type of fat that is easily converted into ketones by the liver. MCTs have been shown to support ketosis by increasing the production of ketones in the body and promoting fat metabolism.
Potential Benefits of Fit Science Keto Gummies
One of the primary benefits of Fit Science Keto Gummies is their ability to help you achieve and maintain ketosis more easily. By providing your body with a source of exogenous ketones and other ketosis-supporting nutrients, these gummies may help kickstart the fat-burning process and keep you feeling energized throughout the day.
In addition, Fit Science Keto Gummies may also help reduce cravings and promote feelings of fullness, making it easier for you to stick to your ketogenic diet and avoid unhealthy snacking. This can be especially helpful for individuals who struggle with food cravings or have a hard time controlling their appetite while following a low-carb diet.
Furthermore, the ingredients in Fit Science Keto Gummies have been shown to support cognitive function and mental clarity, which can be beneficial for individuals who are looking to enhance their focus and productivity while on a ketogenic diet. By providing your brain with a source of ketones, these gummies may help improve cognitive performance and support overall brain health.
Are Fit Science Keto Gummies Right for You?
Before incorporating Fit Science Keto Gummies into your daily routine, it is important to consult with a healthcare professional or nutritionist to determine if they are suitable for your individual needs and goals. While these gummies may offer potential benefits for ketosis support, they are not a one-size-fits-all solution and may not be suitable for everyone.
It is also important to remember that Fit Science Keto Gummies are meant to be used in conjunction with a balanced diet and regular exercise routine. They are not a magic pill that will automatically help you lose weight or achieve your fitness goals. Instead, they should be seen as a tool to support your overall health and wellness as you work towards your desired outcomes.
If you are looking for a convenient and tasty way to enhance your ketogenic lifestyle, Fit Science Keto Gummies may be worth considering. With their blend of exogenous ketones and other key nutrients, these gummies are designed to provide you with the support you need to stay on track with your keto goals and maximize your results.
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Season 2 Episode 18
IM BACCCCKKK with another video on my weightloss journey. I've had so many people reach out to me asking me questions on how I lost my weight. I'm still not done as I have 40 lbs left to lose but I hope that this video can help you on your journey!
If you have any questions or comments, please comment down below or dm me!
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