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Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity
NEJM : DOI: 10.1056/NEJMoa2302392
Orforglipron es un agonista oral no peptídico del receptor GLP-1 que se está desarrollando para el control del peso y el tratamiento de la diabetes tipo 2.
Orforglipron actúa como un potente agonista parcial del receptor GLP-1. GLP-1 (Péptido similar al glucagón-1) es una hormona que juega un papel en la regulación de la glucosa y el control del apetito.
Orforglipron tiene un mecanismo único de activación del receptor GLP-1. Produce señalización cAMP similar a la producida por el GLP-1 nativo. Sin embargo, conduce a una baja activación de la vía β-arrestina, que regula la internalización del receptor. Este efecto de señalización sesgada puede contribuir a su eficacia.
272 participantes fueron asignados aleatoriamente para recibir diferentes dosis de orforglipron: 12 mg, 24 mg, 36 mg, etc.
Participantes del Estudio: El estudio se centró en participantes que tenían obesidad (índice de masa corporal IMC 30) o estaban con sobrepeso (IMC entre 27 a 30) con al menos una condición relacionada con el peso, como hipertensión, dislipidemia, enfermedad cardiovascular o apnea obstructiva del sueño. Se requería que los participantes tuvieran un peso corporal estable (5% de ganancia o pérdida) durante los 3 meses anteriores a la aleatorización.
Semana 26:
Orforglipron 12 mg: -9.0 kg
Orforglipron 24 mg: -12.3 kg
Orforglipron 36 mg: -12.9 kg
Orforglipron 45 mg: -13.3 kg
Placebo: -2.1 kg
Semana 36:
Orforglipron 12 mg: -9.8 kg
Orforglipron 24 mg: -13.6 kg
Orforglipron 36 mg: -14.2 kg
Orforglipron 45 mg: -15.4 kg
Placebo: -2.4 kg
Estos valores representan el cambio medio estimado en el peso corporal desde el inicio para cada grupo. Se observó que la reducción de peso dependía de la dosis, con dosis más altas de Orforglipron resultando en una mayor pérdida de peso en comparación con el grupo placebo.
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One of the key selling points of Keto Charge is its powerful blend of ingredients designed to help the body reach and maintain ketosis. These ingredients include beta-hydroxybutyrate (BHB) salts, MCT oil, and exogenous ketones. BHB salts are known for their ability to increase ketone levels in the blood, which can kickstart the fat-burning process. MCT oil is a type of fat that is quickly converted into ketones by the liver, providing a fast source of energy for the brain and body. Exogenous ketones are ketones produced outside the body, which can help increase ketone levels and enhance the effects of the ketogenic diet.
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One of the main benefits of Keto Charge is its ability to help the body enter ketosis faster and stay in this fat-burning state longer. By providing the body with a source of exogenous ketones, Keto Charge can help reduce the time it takes for the body to transition from using glucose as fuel to using fat for energy. This can lead to faster weight loss and increased energy levels, making it easier to stick to the ketogenic diet and achieve desired results.
In addition to promoting weight loss, Keto Charge may also offer other health benefits, such as improved mental clarity, reduced cravings, and increased endurance during exercise. These benefits can make it easier to maintain a ketogenic lifestyle and support overall health and well-being.
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While Keto Charge is generally considered safe for most people, there are some potential side effects to be aware of. Some individuals may experience symptoms such as headaches, fatigue, or digestive issues when first starting the product. These side effects are often temporary and can be minimized by starting with a lower dose and gradually increasing as the body adjusts to ketosis.
It is also important to consult with a healthcare provider before starting Keto Charge, especially if you have any underlying health conditions or are taking medications. Pregnant or nursing women, as well as individuals with diabetes or other metabolic disorders, should avoid using Keto Charge without medical supervision.
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Overall, Keto Charge offers a promising solution for individuals looking to jumpstart their ketogenic diet and achieve weight loss goals. The ingredients in Keto Charge are backed by science and have been shown to support ketosis and fat burning. However, it is important to remember that there is no magic pill when it comes to weight loss, and results may vary depending on individual factors such as diet, exercise, and overall health.
Before starting Keto Charge or any other dietary supplement, it is important to do your research, consult with a healthcare provider, and set realistic expectations for your weight loss journey. With dedication, consistency, and the right support, you can achieve your health and wellness goals on the ketogenic diet.
Summary
In conclusion, Keto Charge is a dietary supplement that promises to help the body enter ketosis faster and burn fat for fuel, leading to rapid weight loss. The ingredients in Keto Charge are backed by science and have been shown to support ketosis and fat burning. While the product may offer benefits such as improved mental clarity and increased energy levels, it is important to consult with a healthcare provider before starting Keto Charge, especially if you have underlying health conditions or are taking medications. With dedication and the right support, Keto Charge may help you achieve your health and wellness goals on the ketogenic diet.
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