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Over a quarter of the Indian adult population is either obese, at risk of diabetes or are diabetic. This has become a marketing & business opportunity for a lot of fitness & healthtech companies with plain vanilla no science interventions focussed on either high protein, calorie counting, CGM driven or at worst GLP-1 drugs. But these companies fail to understand how human biochemistry works. These interventions, if they help in weight loss, is a stop gap arrangement. Weight gain is not the cause but the effect & symptom. Obesity is triggered by low grade chronic inflammation & our body tries its best to maintain a metabolic homeostasis. However, regular insults we do to our body by consuming toxins or ingesting those foods that are transformed by your microbiome into toxins or pro-inflammatory metabolites makes it hard for us to lose weight. Some of these metabolites include LPS, TMAO, P-cresol & more. While microbes living in our mouth & gut also produce certain beneficial metabolites & incretin hormones ( providing we are feeding them with the right food substrates) that maintain our metabolic health & make it hard for us to gain weight. One of the most important metabolites ( incretin hormone) is GLP-1. Yes, our body automatically produces GLP-1 by synthesising fibre & polyphenols in the food we eat. GLP-1 has multiple benefits via regulating various metabolic pathways-regulates blood sugar response, communicates with brain via gut-brain axis , telling that you are full & even tells stomach & intestine to slow the movement of digestive tract. However, these GLP-1 drugs which lot of companies claim mimics natural GLP-1 brings multiple side effects & just ingesting these drugs does not mean it will help you lose weight. -Effectiveness of GLP-1 drugs depends upon the functions of your microbiome. Certain microbes can synthesise these drugs into beneficial stuff that have positive correlation with glycemic reduction while some others if active & expressing virulence genes can interfere with synthesis of GLP-1 drugs . -Certain microbes if active & expressing virulence genes can degrade GLP-1, making you gain weight or develop type 2 diabetes. In such scenario, these drugs cannot help. -It has been found that obese have underexpressed NOS attributed to overexpression of tumour necrosis factor-α caused by microbial derived endotoxin LPS. Besides, there are multiple other factors that can suppress NOS/cause endothelial cell dysfunction such as overexpression of ADMA, oxidative stress( caused by P-cresol &/or Indoxyl Sulphate Production), TMAO & more. In order to understand the root cause of obesity, there is a need to understand multiple molecular pathways that trigger its onset/progression. We at Genefitletics measures these pathways to construct nutritional therapeutics interventions aligned with your biochemistry that reinstates yout metabolic homeostasis Citations https://pmc.ncbi.nlm.nih.gov/articles/PMC4112002/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7021470/ https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.14725 https://pmc.ncbi.nlm.nih.gov/articles/PMC10391832/ https://diabetesjournals.org/care/article/33/2/453/27096/GLP-1-Based-Therapy-for-Diabetes-What-You-Do-Not https://pmc.ncbi.nlm.nih.gov/articles/PMC5082693/ #obesity #obesityfreeindia #obesityfreenation #obesityawareness #viralvideo #virlshort #viralreels #viral_video #viralshorts #viralnews #healthnews #healthtips #health #healthylifestyle #supplements #obesitymedicine #obesityprevention #obesityawareness #type2diabetes #diabetesawareness #diabetesmanagement #diabetescare #diabetescure

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Are your weight loss efforts falling short? The science behind fat loss is shifting—let's uncover the latest breakthroughs you need to know! The weight loss industry is changing, and it's time to update the old methods. In this episode, we dive into groundbreaking research that reveals the crucial biological factors impacting your weight. From metabolic adaptation to the power of hormones, we'll explore why traditional diets often fail and how new weight loss drugs like Wegovy are changing the game for good. Don’t miss these insights! 🎯 Join us. Like what you're seeing? Hit that Subscribe button and turn on the bell — we’ve got new episodes every week breaking down the science behind weight loss. 💬 Got thoughts on this topic? Agree, disagree, or just curious? Drop a comment below — I read them all and use your input to shape future episodes. ▶️ Watch the full playlist here for more episodes on weight loss science, breakthrough meds, and industry trends: https://www.youtube.com/playlist?list=PLNeSkKrCzsVYuvKK-K7Npt58kCSRyKgEy 📌Timestamps 00:00 Intro 01:49 The Problem with Traditional Advice (metabolism, hormones, food) 04:02 What Science Says Now (metabolism, hormones, food) 05:50 Why this Matters to You (hormones, bug microbiota, foods) 07:29 Thinking Thin Spotlight (body fat shaped by birth month) 08:24 The Meme Report 09:13 Outro 🛍️Affiliate Disclosure Some links in this video may be affiliate links, meaning that we could earn a commission if you make a purchase. 🗒️Content Disclaimer The information shared in this video reflects opinions, not absolute facts. While we make every effort to verify details, errors can occur. We are not responsible for inaccuracies or omissions. Any critiques or discussions are made in good faith for educational and informational purposes. ©️ Copyright Notice All content, including videos, graphics, and captions, is copyrighted by TTR. Unauthorized use, reproduction, or distribution is strictly prohibited. ⚕️Medical Disclaimer I am not a doctor. This video is for informational purposes only and should not be considered medical advice, or as a substitute for medical advice. Individual medical needs vary, so do not assume that details about specific treatments or outcomes apply to your situation. Always consult a qualified healthcare provider regarding any medical concerns. Hashtags #WeightLossDrugs #GLP1 #Wegovy #Zepbound #Metabolism #hormones Full Spotlight article available at: https://www.sciencealert.com/your-body-fat-may-be-shaped-by-the-month-you-were-conceived

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