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Catecholamines play a key role in nutrient metabolism and the generation of body heat, aka thermogenesis
They stimulate not only oxygen consumption but also consumption of fuels, such as glucose and free fatty acids, thereby generating heat
They stimulate glycogenolysis and the breakdown of triglycerides, the stored form of fat, to free fatty acids (lipolysis)
Study - Journal of the International Society of Sports Nutrition
Researchers looked at the effects of a fat loss supplement on resting metabolic rate and hemodynamic variables in resistance-trained males
10 resistance-trained male participants underwent two testing sessions separated by at least 24 hours
On their first visit, participants arrived to the laboratory after an overnight fast and a 24 hour avoidance of exercise, and underwent a baseline RMR, HR, and BP assessment
Next, each participant ingested a thermogenic fat loss supplement (TFLS) or a placebo (PLA) and repeated the RMR, HR, and BP assessments at 60, 120, and 180 min post-ingestion
During the second visit the alternative supplement was ingested and the assessments were repeated in the exact same manner
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The thermogenic fat loss supplement (Iron Cuts) treatment and placebo were ingested in capsule form, and three capsules were ingested per dose
Capsules were identical in appearance and taste, and the ingredients in the thermogenic fat loss supplement treatment were:
L-Carnitine Tartrate, Green Tea Leaf Extract, Caffeine Anhydrous, Panax Ginseng Root Powder, N-Acetyl-L-Tyrosine, Thermodiamine™ (98 % Evodiamine), Vinpocetine, Inositol.
The placebo contained only inert ingredients (650 mg of maltodextrin and 88.8 mg of hemp protein)
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TFLS significantly increased RMR at 60-min, 120-min, and 180-min post ingestion as compared to baseline RMR values
No significant changes in RMR were observed for the PLA treatment
Specifically, RMR was increased by 7.8 % (from 1,906 to 2,057 kcal), 6.9 % (from 1,906 to 2,037 kcal), and 9.1 % (from 1,906 to 2,081 kcal) in the TFLS, while the PLA treatment increased RMR by 3.3 % (from 1,919 to 1,981 kcal), 3.1 % (from 1,919 to 1,978 kcal), and 2.1 % (from 1,919 to 1,959 kcal) above baseline at 60, 120, and 180-min post ingestion, respectively
Additionally, the TFLS significantly elevated RMR at the 3-hour time point as compared to the PLA treatment (2,081 vs 1,959 kcal)
A main effect for groups was observed for systolic blood pressure, and a significant interaction and main effect for time were observed for diastolic blood pressure
It should be noted that although changes in diastolic blood pressure were significant, all values stayed within normal clinical ranges (less than 80 mmHg)
Concluded that the fat burner led to significant elevations in RMR as compared to baseline, and that these elevations came with no adverse effect relative to resting heart rate, but a slight increase in blood pressure values
So taken on a daily basis, the fat burner may increase an individual’s overall energy expenditure
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818444/
*A meta-analysis published in the journal Appetite 20 of which were selected for inclusion, involving 563 participants looked at capsaicin in the potential role for weight management
that consumption of capsaicinoids increases energy expenditure by approximately 50 kcal/day, and that this would produce clinically significant levels of weight loss in 1-2 years
https://www.ncbi.nlm.nih.gov/pubmed/22634197
Fat burners are designed to have a thermic effect on the body, causing your resting RMR to increase - the idea is that they’re additional calories being burned without the additional work,
However, it’s unclear whether this effect leads to significant weight loss or reductions in body fat in the long run - likely would, but chronic use would be required
References
1) Jeukendrup AE and Randell R. (n.d.). Fat burners: nutrition supplements that increase fat metabolism. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21951331
2) The effects of a fat loss supplement on resting metabolic rate and hemodynamic variables in resistance trained males: a randomized, double-blind, placebo-controlled, cross-over trial. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818444/
3) Whiting S , et al. (n.d.). Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22634197
4) Thermogenesis - an overview | ScienceDirect Topics. (n.d.). Retrieved from https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/thermogenesis
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The weight loss industry has seen significant growth over the years, with new products and methods constantly being introduced to help individuals achieve their desired body goals. One of the most anticipated developments in this field is the emergence of a new weight loss drug in 2024. While details about this new drug are still limited, experts are already speculating about its potential impact on the market and what individuals can expect from it.
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Researchers have been working tirelessly to develop a weight loss drug that can effectively help individuals shed excess pounds without causing harmful side effects. The new drug is said to target specific mechanisms in the body that regulate metabolism and fat storage, making it a promising solution for those struggling to lose weight through traditional methods.
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Finding an effective weight-loss solution can be a challenging task for many individuals. With countless products and diets on the market, it can be overwhelming to determine which option is right for you. For years, Oprah Winfrey has been a beacon of inspiration for those seeking to improve their health and wellness. Recently, she revealed her single secret weapon against weight: Oprah Keto Gummy. This revolutionary product has taken the weight-loss world by storm, promising incredible results without the need for drastic diet changes or intense exercise regimens. Let’s explore the power of Oprah Keto Gummy and how it can help you achieve your weight-loss goals.
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