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In this episode of the Talking Studies Series, I cover a fairly hot topic: GLP-1 receptor agonists (GLP-1RAs), the popular weight-loss drugs. Specifically, I cover a study that tested exercise, liraglutide (a GLP-RA), and liraglutide plus exercise as interventions for maintaining weight-loss. And, I zero in on how both the original liraglutide-free weight-loss period and the different interventions during the maintenance phase impacted lean mass—a proxy for muscle mass. --------------------------------------------------------------------------------------------------------------------------- Links from the video: Main study discussed: https://www.nejm.org/doi/10.1056/NEJMoa2028198 “Preserving Healthy Muscle during Weight Loss”: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421125/ “A systematic review of the separate and combined effects of energy restriction and exercise on fat-free mass in middle-aged and older adults: implications for sarcopenic obesity”: https://academic.oup.com/nutritionreviews/article/68/7/375/1821484?login=false “Resistance Training Prevents Muscle Loss Induced by Caloric Restriction in Obese Elderly Individuals: A Systematic Review and Meta-Analysis”: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946208/ “GLP-1 receptor agonists: an updated review of head-to-head studies”: https://journals.sagepub.com/doi/10.1177/2042018821997320?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed --------------------------------------------------------------------------------------------------------------------------- More From Shortcut U: - Blog: https://shortcutu.substack.com/ - Free Beginner Lifting Program: https://open.substack.com/pub/shortcutu/p/the-beginners-build-program?r=qcnj7&utm_campaign=post&utm_medium=web - Free Spring Break Program: https://springbreakbuild.com/
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