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The Future of Obesity Therapy and the Development of GLP-1 Drugs
Today, we have Tirzepatide (brand names: Zepbound, Mounjaro) and Semaglutide (Ozempic, Wegovy).
Who’s next?
When will the next weight loss injection — or finally a weight loss pill — be released in the coming years?
Let’s take a look at the overview table together.
From left to right:
This table provides an overview of upcoming and future pharmaceutical drugs for weight loss or metabolic disorders, categorized by year, company, drug name, and pharmaceutical formulation (oral or injection).
Orforglipron (Eli Lilly) – Oral GLP‑1RA small molecule taken once daily
Clinical results:
Phase III ACHIEVE‑1 (type 2 diabetes): Lowered A1C by 1.3–1.6 pp and body weight by ~7.9% (~16 lb) at 40 weeks vs ~1.6% weight loss for placebo businessinsider.com+5
Oral Semaglutide – Novo Nordisk (“Rybelsus”)
Novo Nordisk has submitted an application to the U.S. Food and Drug Administration (FDA) for oral semaglutide (a 25 mg once‑daily formulation of Wegovy) aimed at chronic weight management:
,based on encouraging Phase III OASIS‑4 data 25md oral Semaglutide is showing around 13.6 % mean weight loss at 64 weeks
In May 2025, the FDA officially accepted the NDA and will decide in Q4 2025
Retatrutide (LY‑3437943) – Eli Lilly
Mechanism: A triple agonist targeting GLP‑1, GIP, and glucagon receptors prnewswire.com+15
hase 2 (48 weeks):
8 mg dose → –22.8% body weight reduction
12 mg dose → –24.2% body weight reduction (~58 lb)
Also reduced liver fat in patients with metabolic steatotic liver disease
VK2735 – Viking Therapeutics (injectable + oral)
Mechanism: Dual GLP‑1 and GIP receptor agonist (similar to tirzepatide) en.wikipedia.org.
Formulations:
Subcutaneous (weekly): Phase 2 data showed up to 14.7% weight loss in 13 weeks, with 88% of subjects achieving ≥10% weight loss pharmexec.com.
Oral (daily): Phase 1 MAD study:
Up to 8.2% weight loss over 28 day
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Semaglutide 6 Week Belly Ozempic Weight Loss Before and After: A Comprehensive Transformation Journey
Introduction
Weight loss is a journey that many individuals embark on, seeking to improve their health and well-being. For some, traditional methods such as diet and exercise may not yield the desired results. In such cases, medications like Semaglutide 6 Week Belly Ozempic have emerged as a promising solution. This article will delve into the before and after results of using Semaglutide for weight loss, exploring the transformation journey of individuals who have taken this medication.
Starting Point
Before beginning their journey with Semaglutide, many individuals struggled with excess weight that not only took a toll on their physical health but also impacted their mental and emotional well-being. The decision to try Semaglutide was often a last resort after years of failed attempts with traditional weight loss methods. Despite initial skepticism, these individuals were willing to try a new approach in the hopes of achieving lasting results.
Upon starting Semaglutide, individuals were closely monitored by healthcare professionals to ensure proper dosage and frequency of administration. They were educated on the mechanisms of action of Semaglutide and how it could aid in weight loss. With regular check-ins and adjustments to their treatment plan, individuals embarked on their transformation journey with optimism and determination.
As the weeks progressed, individuals began to notice significant changes in their weight and overall health. With consistent use of Semaglutide and adherence to lifestyle modifications, many experienced gradual but sustainable weight loss. This not only boosted their confidence but also motivated them to continue on their path towards better health.
Transformation Journey
Throughout the 6-week period of using Semaglutide, individuals documented their progress through before and after photos, showcasing the remarkable changes in their physical appearance. Belly fat, in particular, was a common problem area for many, and the reduction in waist circumference was a visible indicator of the effectiveness of Semaglutide in targeting stubborn fat deposits.
Aside from weight loss, individuals also reported improvements in their energy levels, mood, and overall quality of life. The reduction in cravings and hunger pangs allowed them to make healthier food choices and maintain a balanced diet. This newfound sense of control over their eating habits was empowering and contributed to their continued success on the weight loss journey.
By the end of the 6 weeks, individuals were not only lighter on the scale but also lighter in spirit. The transformation journey with Semaglutide had brought about profound changes in their lives, instilling a sense of confidence and self-assurance that they had never experienced before. With the support of healthcare professionals and their own dedication, they had achieved what once seemed impossible.
Conclusion
In conclusion, the before and after results of using Semaglutide for weight loss highlight the transformative power of this medication in helping individuals achieve their health goals. Through dedication, perseverance, and the support of healthcare professionals, individuals can embark on a comprehensive transformation journey that not only results in physical changes but also cultivates a mindset of self-care and empowerment. The success stories of these individuals serve as inspiration for others who may be struggling with weight loss, showing that with the right tools and mindset, lasting change is possible.
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