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PSA for all the women on GLP-1s and hormone replacement therapy (HRT): you’re going to want to hear this. 👩‍⚕️ If you’ve been prescribed a GLP-1 medication (like Ozempic, Wegovy, Mounjaro, etc.) and you’re on HRT, there’s something important you need to know: these medications can impact estrogen levels. What does that mean? It means your estrogen levels may drop without you realizing it—and that can bring back symptoms you thought were behind you (hot flashes, night sweats, mood swings, low libido... sound familiar?). The fix? You may need to adjust your estrogen dose or consider alternative delivery methods (like transdermal patches or gels) that aren’t affected by GI absorption. This isn’t about fear—it’s about being informed and empowered. If this sounds like you, have a conversation with your clinician. You deserve to feel your best. 💛 Don't forget to follow for all things perimenopause, menoapuse, midlife and HRT.

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FDA's Bold Move on Drug Approvals & Promising GLP-1 Research In this episode of Downsized News, hosts Laraine and Christopher Durham delve into the latest developments surrounding GLP-1 medications and their broader implications for obesity and related health issues. Key highlights include the FDA's ambitious plan to expedite drug approval times with the Commissioner's National Priority Voucher (CNPV) program, a significant court ruling favoring the FDA and Novo Nordisk on Semaglutide compounding, and promising research showing GLP-1's potential benefits for fibromyalgia sufferers. Moreover, updates on new drugs like DDO-1 and Dapaglutide, and emergent therapies such as Sana for fat burning and gene-editing treatments for cardiovascular disease, are discussed. The episode wraps up with perspectives on the ongoing policies potentially curbing drug advertisements and the notable phase-out of Saxenda in favor of more advanced medications like Wegovy. DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store As an Amazon Associate I earn from qualifying purchases. Join CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED WEBSITE: https://thedownsized.org/ FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Introduction and Welcome 01:07 FDA Ruling on Semaglutide Compounding 02:30 New FDA Pilot Program for Drug Approval 05:21 GLP-1s and Fibromyalgia Relief 08:45 New GLP-1 Drug from South Korea 12:28 Discontinuation of Saxenda in Australia 14:51 Zealand Pharma's Dapiglutide 17:02 Experimental Obesity Pill: Sana 21:26 Potential Ban on Drug Ads 24:57 Eli Lilly's Acquisition of Verve Therapeutics 28:01 Conclusion and Farewell