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In this video, Dr. Eric Westman reacts to the newly released Keto CTA trial results on lean mass hyper-responders — individuals with extremely high LDL cholesterol levels on a keto diet but otherwise healthy profiles. Was the study a failure? Or does it challenge everything we thought we knew about LDL and heart disease? 👁️ Seen a video you'd like me to react to? Leave a comment below or join the YouTube membership for priority comments where your video recommendation will be seen first and any questions you may have will be answered 🎬 For more Reacts Video Click Here: https://www.youtube.com/playlist?list=PL55Chm2jfDSpOrkAYNuux9Pri4k5QmrZu 🟣 If you enjoy my channel and would like to support what I do there are a few different ways you can show your support listed below: 🟣BECOME A CHANNEL MEMBER ON YOUTUBE Receive priority comments, early access to new videos and join livestreams twice a month to ask me anything live! 🟣Support the channel via PayPal if you don't want anyone taking a chunk of what you send me and you can set up a recurring payment https://www.paypal.com/donate/?hosted_button_id=ZDZK4SN7DJYXC 🟣Vist Adapt Your Life Academy https://adaptyourlifeacademy.com/ 🟣Adapt Your Life Academy Online Courses: https://adaptyourlifeacademy.com/all-courses/ 🟣Bestselling Book – END YOUR CARB CONFUSION: https://www.amazon.com/Your-Carb-Confusion-Eric-Westman 🟣END YOUR CARB CONFUSION COOKBOOK: https://www.amazon.com/End-Your-Carb-Confusion 🟣FREE QUIZ to determine your personal carb threshold: https://adaptyourlifeacademy.com/carb-threshold-bonus/ ======================================================================== 🟣MY SOCIAL MEDIA 🟣Like my Facebook Page ➡️ https://www.facebook.com/AdaptYourLifeAcademy 🟣Follow me on Instagram ➡️ https://www.instagram.com/adaptyourlifeacademy/ 🟣Follow me on X ➡️ https://x.com/drericwestman ======================================================================== 🟣Dr. Eric Westman, Associate Professor of Medicine at Duke. He is Board Certified in Obesity Medicine & Internal Medicine, & founded the Duke Keto Medicine Clinic. He is a Fellow in The Obesity Society. He is the author of The New Atkins for a New You, Cholesterol Clarity, and Keto Clarity, and End Your Carb Confusion & co-founder of Adapt Your Life. Disclaimer: Nothing on our channel is medical advice. Dr. Westman and the Adapt Your Life team do not diagnose, treat, cure, or prevent any medical conditions online. We provide education to help people better understand their own health and support their well-being. Make sure you are working with YOUR licensed provider to monitor your health and medications. These posts and videos are not designed to and do not provide medical advice, professional diagnosis, opinion, treatment, or services to you or to any other individual. We do not promote or endorse affiliate links and/or products unless they are our own.
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Incidence of Obesity & Type 2 diabetes is increasing more than ever!
The current set of interventions are restricted to tracking blood sugar level using CGM, fad diets, high protein diets & pharmaceutical drugs.No wonder the therapeutic success is dismal!
Now India is experiencing another wave of synthetic compound approach- GLP-1 receptor Agonists with a hope to control glycemic control, trigger weight loss & improve cardiovascular health.
While at macro level this synthetic compound looks like a effective solution, if we dug deeper it may be starting point of metabolic disaster
What exactly is GLP-1?
GLP-1 is an incretin hormone naturally produced inside our body. Our gut microbiome could synthesise fibre, polyphenols & even N-oleoyl serinol in olive oil into GLP-1. This incretin hormone promotes satiety regulation, blood sugar control & even regulates heart health
If the body is not able to produce GLP-1, then it is a biochemistry problem & the body is not at ease. Since there has been no tech that could measure GLP-1 levels( we the only company in India that can measure & quantify this incretin hormone), it is assumed that people suffering from obesity or type 2 diabetes suffer from GLP-1 deficiency.
However no one actually measures specific inflammatory factors causing obesity. Is it really a GLP-1 deficiency? Or high P-cresol production? Low Butyrate Production? Elevated TMAO or high LPS?
Until you know the source code for obesity how can you even prescribe interventions to address the disease. GLP-1 receptor Agonists may work for some people who actually have GLP-1 deficiency. However, the effectiveness of this drug depends upon:
1.Functions of your microbiome. Certain microbes can synthesise these drugs into beneficial stuff that have positive correlation with glycemic reduction while some others if active & expressing virulence genes can interfere with synthesis of GLP-1 drugs
2.Certain microbes if active & expressing virulence genes can degrade GLP-1, making you gain weight or develop type 2 diabetes. In such scenario, these drugs cannot help
3.GLP-1 drugs also activates endothelial nitric oxide synthase which could potentiate nitric oxide signalling that could dilate blood vessels, regulate glucose uptake & have anti-obesity impact. However for this to function, this enzyme should be coupled with endothelial cells. If it is uncoupled due to systemic inflammation or oxidative stress, it cannot trigger production of nitric oxide & these GLP-1 drugs will not work
4. These drugs act as an artificial break on your satiety paddle & slow down movement along your digestive tract & would cause constipation, bloating & other digestive troubles.
5. Even for people this drug works, they need to take this continuously as withdrawal from these drugs would lead to weight gain
Citations
https://diabetesjournals.org/care/article/33/2/453/27096/GLP-1-Based-Therapy-for-Diabetes-What-You-Do-Not
https://pmc.ncbi.nlm.nih.gov/articles/PMC8793908/
https://pmc.ncbi.nlm.nih.gov/articles/PMC7021470/
https://pmc.ncbi.nlm.nih.gov/articles/PMC8833664/
https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.14725
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This video refers to guidelines produced by the "National Institute for Health and Care Excellence" in the UK, also referred to as "NICE". The content on this channel reflects my professional interpretation/summary of the guidance and I am in no way affiliated with, employed by or funded/sponsored by NICE. My name is Fernando Florido and I am a General Practitioner in the United Kingdom. In this video I look at GLP1 agonists in type 2 diabetes according to NICE. I am not giving medical advice; this video is intended for health care professionals, it is only my summary and my interpretation of the guidelines and you must use your clinical judgement. There is a podcast version of this and other videos that you can access here: Primary Care guidelines podcast: • Redcircle: https://redcircle.com/shows/primary-care-guidelines • Spotify: https://open.spotify.com/show/5BmqS0Ol16oQ7Kr1WYzupK • Apple podcasts: https://podcasts.apple.com/gb/podcast/primary-care-guidelines/id1608821148 There is a YouTube version of this and other videos that you can access here: • The Practical GP YouTube Channel: https://youtube.com/@practicalgp?si=ecJGF5QCuMLQ6hrk
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Are you looking for a better way to manage your patients' glycemic variability? If so, you're in the right place. In this video, we'll discuss how functional medicine can help, and what emerging therapeutic agents like GLP1 agonists and DPP 4 inhibitors can do to help you better manage glycemic variability. So if you're looking for the latest in functional medicine advice on glycemic variability, this is a must-watch. Tune in now! VIDEO RESOURCE: ======================== This video is from Clinician's Code, a full-scale learning experience for health professionals looking to better help their patients and build a thriving, evidence-based functional medicine practice. You can learn more here - https://www.metabolicfitnesspro.com/clinicianscode-apply FREE RESOURCE: ======================== If you enjoyed this video, check out the free One Day Functional Medicine Course here – https://www.metabolicfitnesspro.com ABOUT DR. BRYAN WALSH ======================== Dr. Walsh has been studying human physiology and nutrition for over 25 years and has been educating others in health for 20 of those years. When he isn’t teaching, he spends his time pouring over the latest research and synthesizing his findings into practical information for clinicians to use in practice. Dr. Walsh is best known for his expertise in biochemistry and human physiology, which allows him to (happily) dismantle the myths and misconceptions in the functional medicine industry and replace them with the truth. His work is most often described as, “the functional medicine education you always wanted, but never received". https://www.metabolicfitnesspro.com