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We’re LIVE from the Caribbean aboard the Celebrity Reflection! 🌴
Tonight’s special edition of Downsized Live is coming to you straight from the Downsized at Sea Cruise 2025, proudly presented by Mochi Health.
⛴️ We’re sailing with 54 fellow GLP-1 users—real people from all over the country treating the disease of obesity with Zepbound, Mounjaro, Wegovy, Ozempic, semaglutide, and tirzepatide—and we’re bringing this unforgettable experience to you.
💬 We’ll be answering your questions live—about side effects, mindset, medication tips, long-term goals, and everything in between. Whether you're just getting started or deep into your adventure, this is your space to learn, ask, and share.
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Semaglutide Injections For Weight Loss What You Need To Know
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Even as we prioritize natural interventions in functional medicine, GLP-1 agonist drugs such as Wegovy and Ozempic offer sometimes life-changing support for those who have long struggled with resistant overweight/obesity and high blood sugar. However, there are side effects, including the risk of substantial muscle loss and sagging, aged skin ("Ozempic face" as it's indelicately known). It's a concern that hits home for me, considering the pivotal role we know that muscle plays in overall health and longevity.
In this New Frontiers podcast episode I welcome back Dr. Anurag Singh to unravel the complexities of these issues. We explore the interplay between metabolic health and muscle preservation, touching on everything from the mechanisms of GLP-1 agonists and their long-term effects on aging and sarcopenia, to the promising potential of dietary and lifestyle interventions to counteract negative effects. We consider the potential for one of my all-time fave postbiotic epinutrients - Urolithin A - to assist by supporting mitochondrial health and preserving/enhancing muscle quality. This timely conversation is one you won't want to miss. Tune in and please leave us a review wherever you listen to New Frontiers. – DrKF
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.
*Guest information*
Anurag Singh, MD, PhD
Chief Medical Officer at Timeline
*Thank you to our sponsor*
Timeline: https://tinyurl.com/4npjcvjf
Mitopure: https://tinyurl.com/ypfjws2e
Research from Timeline: https://tinyurl.com/53p6yjc9
[email protected]
*Timeline Discount for New Frontiers Listeners*
Timeline is offering Dr. Fitzgerald’s readers a 10% discount on Timeline products. Head on over to https://tinyurl.com/ypfjws2e and use the code KARA10 at the checkout.
*Show Notes*
Study: Once-Weekly Semaglutide in Adults with Overweight or Obesity: https://tinyurl.com/y3c2ypkw
Pre-clinical trial (Recruiting): Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55= Years Old: A Randomized Triple-Masked Controlled Clinical Trial - https://https://tinyurl.com/bdzfccr8
Study: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults - https://tinyurl.com/2p9pjpxc
Study: Antidiabetic Effect of Urolithin A in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Glucose Intolerance - https://tinyurl.com/2jkhmu9w
Study: Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis - https://tinyurl.com/mvrjxxsm
Study: Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial - https://tinyurl.com/fscfdd85
Study: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans - https://tinyurl.com/mr2hd4ms
Study: Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population - https://tinyurl.com/e6npdvyp
Preprint article: Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials - https://tinyurl.com/2m2nzd56
Preclinical trial: Effects of Mitopure (Urolithin A) on Skeletal Muscle Function, Iron Metabolism and Endurance Performance (ENDURO) - https://tinyurl.com/nhkw2pvc
Study: The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome - PubMed (nih.gov) - https://tinyurl.com/mrkk33e5
Study: Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice | PLOS Biology - https://tinyurl.com/3s38vtau
Study: Urolithin A production drives the effects of pomegranate on the gut microbial metabolism of bile acids and cholesterol in mild dyslipidaemic overweight and obese individuals - PubMed (nih.gov) - https://tinyurl.com/wdzk3tx7
*DrKF Resources*
FxMed Podcast: Beyond Mitochondrial Health: Can Urolithin A Slow Down Aging? - https://tinyurl.com/svzahswu
DrKF Blog: Beyond Beauty: Targeting Skin Longevity with Urolithin A - https://tinyurl.com/5n6zfu9s
DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb
Bio Age Lab Test: https://tinyurl.com/b7bjmfj9
Bio Age Self Assessment Quiz: https://tinyurl.com/4z8f7ucc
Younger You Group Program: https://tinyurl.com/4hvusavw
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw
The ketogenic diet has grown in popularity over the years as a diet that aids in weight loss and improves overall health. The diet consists of high-fat and low-carb foods, putting the body in a state known as ketosis which results in fat burning rather than carbohydrates. While many have experienced success with the keto diet, there are supplements like Regal Keto that people have resorted to for enhancing their performance and results.
Regal Keto on Shark Tank: Does It Live Up to the Royal Name?
Regal Keto is a dietary supplement that allegedly allows one to reach the key state of ketosis in just two weeks. Prominent in the news, this product ruptured headlines amidst rumours that the brand found itself in the centre of a virtual bidding war on the popular TV show Shark Tank. So, does Regal Keto live up to its title, or is it just yet another supplement trying to stake its place in an overcrowded market of counterfeit products?
What is Regal Keto?
Regal Keto is a supplement targeted at individuals on a ketogenic diet. Basically, it’s designed to help you go into ketosis much faster and more efficiently than would normally be possible. Regal Keto alludes to a proprietary blend of “100% natural ingredients” that work together to help you “enter ketosis at blazing speed” and experience a “healthy blood sugar balance” and “optimal energy levels” while you’re shedding those excess kilos. Some of the key ingredients are said to include exogenous ketones (chemical compounds that help your body produce more of its own ketones), MCT oil (a super-healthy ‘good fat’ often used in weight loss supplements) and green tea extract (popup:anti-oxidant rich super drink, widely regarded as a metabolism booster and weight loss facilitator thanks to its high concentrations of polyphenols and catechins).
A lot of times, supplements works best when combined with keto diet as an individual feels it is not taking them to the required step as anticipated. Therefore, its merger with supplements like Regal Keto improves the ratio and speed by which fat gets depleted from the body, contributing to the provision of a backup form of energy to the entire body and brain. It eliminates the brain fog felt by a couple of people following the keto diet. Though keto diet is regarded by many clinicians as effective, this is not exceptional for people who find it difficult to stick to it. Therefore, persons following the keto diet associated it with a influx of supplements that assist the diet to be effective.
How Does Regal Keto Work?
The king of ketosis works primarily by supplying the body with exogenous ketones – ketones that are manufactured outside of the body. With the addition of exogenous ketones, consumption of the supplement is believed to help your body enter a state of ketosis, making it easier for you to suppress your appetite, burn fat and lose weight. To complement exogenous ketones, Regal Keto contains MCT (medium-chain triglyceride) oil, another type of fat that is identified by speedily transforming into ketones and subsequently burning as energy.
Green tea extract is a widely used component in Regal Keto, known for its antioxidant and metabolism-boosting effects. By combining ingredients mentioned above, Regal Keto can help those on a keto diet lose weight faster and healthier. Keto supplement should not be seen as a substitute for a keto diet, instead it is additional help for ensuring the process and keeping the results.
Is Regal Keto Worth It?
It will all come down to individual goals and your own personal tastes and conclusions. I hope this little trip down memory lane was an enjoyable one. Who knows. perhaps a Keto snack food might be worth the money after all? While supplements might help some people achieve their body transformation goals faster, they are not some universal weight-loss magic. They are after all merely supplements.
If you are interested to use the Regal Keto supplement in order to get rid of excessive body fat from your body, then you can also speak with your doctor or with a health professional because they can tell you whether the supplement would be right for you and if it can be used for weight loss or not. You can also read user’s reviews because those reviews can help you get an idea of whether the product has worked for others or not. Taking the Regal Keto supplement is your decision and you can make this decision only when you have a clear idea of how it works.
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