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While looking over the research on the effect of GLP-1 receptor agonists on alcohol consumption, I stumbled across a recent and _really_ interesting paper on how that class of drugs affects sensation. It's "Glp-1 Receptor Agonists Significantly Impair Taste Function" by Rafa Khan and Richard L. Doty in _Physiology & Behavior_ Vol. 291 (published version at https://www.sciencedirect.com/science/article/abs/pii/S003193842400341X and white paper version at https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4953499 ). Don't necessarily take that title on its face, as the details are super important and incredibly interesting and maybe not as dire as you'd think. And, well, I felt like it would be a good use of my platform to discuss all of this. So that's what we're doing today, talking about this hugely consequential new class of drugs - Wegovy/Ozempic (semaglutide), Mounjaro (tirzepatide, although that's also a GIP), and whatever else is going to be out there - with an eye towards spirits nerdery. First I broadly discuss the history and basic mechanisms of these drugs, with a brief detour into side effects and what I would consider to be "best practices" in using them for weight loss purposes. (N.b., I don't get into treatment for type 2 diabetes and that's another set of concerns, also I am not a doctor and please consult a medical professional for all this etc..) And then I discuss the paper above. And... well, it's complicated. Based on their results I think the main takeaway is that while GLP-1 agonists seem to have very good odds of degrading your sense of taste, there's also pretty good odds that you won't actually notice. 🤷 Extra special thanks to my Different Spirits on Patreon (https://www.patreon.com/differentspirits), who got this video first - Eric Amig Anthony Darcy Bean Jamie Brown Kingsbury bushcraft William Christopher Clematis Rob D Liam Davitt Joe Devine Samuel Dose Stephen Eckert eon Ingmar nine Steve Frazee Ian Gendler Solomon Grundy John Halliday Alex Hurd Trevor Jarrait Jonathan Lestingi Kyaru Ariel Mserious Craig Nielsen Jason Newquist No Thanks Chris Rhodes Randy Rice RumSquirrel Gordon W Zach W

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Berberine has gained attention as a potential aid for weight loss, but it's important to understand its role in your overall health and fitness journey. While berberine can offer some benefits, it's not a magic solution for shedding pounds. Studies have shown that taking berberine alone, without making any lifestyle changes, may result in modest weight loss - about a kilogram (2.2 pounds) in a month. However, the real power of berberine lies in its ability to support your weight loss efforts when combined with healthy habits. Berberine can potentially enhance your body's glucose processing, inhibit glucose production in the liver (gluconeogenesis), and may affect your appetite and satiation. These effects can amplify the results of your lifestyle changes, making your diet and exercise efforts more effective. Remember, sustainable weight loss comes from a combination of healthy eating, regular exercise, and smart supplementation. Berberine can be a valuable tool in your weight management toolkit, but it works best when paired with positive lifestyle changes. Have you tried berberine or other supplements to support your weight loss journey? We'd love to hear about your experiences in the comments! What kind of videos would you like to see about weight management and supplements? #NootropicsDepot #QualityIsEverything #TransparencyYouCanSee #nootropics #naturalsupplementsthatwork #berberine #weightlossjourney #healthylifestyle #supplementscience

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Day 9 Today is a day of Tired confessions about my outlooks on my weight loss past, present and future. My Daily points :41 Today used: 41 Flex points left: 35 Starting Weight 11/2013: 268.8 1/5/14 Weight: 257.6 Total: 11.2 pounds I weigh in on Sundays so I will update on Sunday Vlogs! Thanks for watching! Please join on the daily vlogging. Love you all and thanks for the support! Lisa B :-)