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Investigation on the Effects of GLP1 analog and SGLT2 inhibitor against Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms Background: The present study investigated the possible cardioprotective effects of GLP1 and SGLT2i against diabetic cardiomyopathy (DCM) in type 2 diabetic rats and the possible underlying mechanisms. DCM is defined as the presence of heart failure in absence of coronary artery disease. Methods: Thirty-two male Sprague Dawley rats were randomly subdivided into 4 equal groups; a) control group, b) DM group, type 2 diabetic rats with saline daily for 4 weeks, c) DM+ GLP1, as DM group with GLP1 analogue (liraglutide) at a dose of 75 µg/kg for 4 weeks, and d) DM+ SGLT2i: as DM group with SGLT2 inhibitor (dapagliflozin) at a dose of 1mg/kg for 4 weeks. By the end of treatment (4 weeks), serum blood glucose, HOMA-IR, insulin and cardiac enzymes (LDH, CK-MB) were measured. Also, the cardiac histopathology, myocardial oxidative stress markers (MDA, GSH and CAT) and norepinephrine (NE), myocardial fibrosis, the expression of caspase-3, TGF-, TNF- and tyrosine hydroxylase (TH) in myocardial tissues were measured. Results: T2DM caused significant increase in serum glucose, HOMA-IR, serum CK-MB and LDH (p less than 0.05). Also, DM caused significant myocardial damage and fibrosis, elevation of myocardial MDA, NE with upregulation of myocardial caspase-3, TNF-, TGF- and TH and significant decrease in serum insulin and myocardial GSH and CAT (p less than 0.05). Administration of either GLP1 analog and SGLT2i caused in significant improvement in all studied parameters (p less than 0.05). Conclusion: We concluded that either of GLP1 and SGLT2i exhibited cardioprotective effects against DCM in T2DM with the upper hand for SGLT2i. This might be due to attenuation of fibrosis, oxidative stress, apoptosis (caspase-3), sympathetic nerve activity and inflammatory cytokines (TNF- and TGF-). #type #2 #cardiomyopathy #oxidative #stress #3 #glp1 #norepinephrine #tgf #tnf #and #tyrosine

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Struggling with weight loss? Semaglutide could be your game changer. This GLP-1 peptide mimics your body's natural hormones to: ✔️ Suppress appetite ✔️ Support healthy blood sugar ✔️ Promote real, sustainable weight loss Backed by clinical studies Guided by licensed doctors 100% online via telehealth At Peptide WebMD, we offer free consultations to personalize your peptide therapy. 👉 Book now at PeptideWebMD.com Start the journey to a healthier you—backed by science. #Semaglutide #GLP1 #PeptideTherapy #WeightLossHelp #SustainableResults #MetabolicHealth #PeptideWebMD #OnlineWellness #TelehealthSupport #ModernMedicine

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Are you looking to achieve real results with the Shark Tank Keto diet? Look no further! In this ultimate guide, we will provide you with everything you need to know about the Real Shark Tank Keto diet. From how it works to its benefits and potential risks, we’ve got you covered. Whether you are just starting out on your weight loss journey or looking to kick things up a notch, this guide will help you navigate the ins and outs of the Shark Tank Keto diet.

How Does the Real Shark Tank Keto Diet Work?

The Real Shark Tank Keto diet is a high-fat, low-carbohydrate diet that forces the body to burn fats rather than carbohydrates for fuel. By drastically reducing your carbohydrate intake and increasing your fat intake, your body enters a metabolic state known as ketosis. In ketosis, your body becomes incredibly efficient at burning fat for energy, leading to rapid weight loss and increased energy levels.

When you follow the Real Shark Tank Keto diet, your body produces ketones, which are used as fuel in place of glucose. This shift in metabolism can help you shed excess pounds, improve your mental clarity, and even reduce your risk of certain diseases such as diabetes and heart disease.

Additionally, the Real Shark Tank Keto diet has been shown to help regulate blood sugar levels, control cravings, and improve overall satiety. By eliminating processed sugars and carbohydrates from your diet and focusing on whole, nutrient-dense foods, you can experience improved health and well-being.

Benefits of the Real Shark Tank Keto Diet

There are numerous benefits to following the Real Shark Tank Keto diet. One of the most significant benefits is weight loss. By shifting your body’s primary fuel source from carbohydrates to fats, you can experience rapid and sustainable weight loss. In addition to weight loss, the Real Shark Tank Keto diet can also help improve energy levels, mental clarity, and focus.

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Many followers of the Real Shark Tank Keto diet report feeling more satisfied and less hungry throughout the day, leading to reduced cravings and better control over their eating habits. This can be a game-changer for those looking to break free from the cycle of overeating and yo-yo dieting.

Other potential benefits of the Real Shark Tank Keto diet include improved blood sugar control, reduced inflammation, and a lower risk of chronic diseases such as diabetes and heart disease. By focusing on whole, unprocessed foods and eliminating sugar and processed carbohydrates from your diet, you can experience improved overall health and well-being.Resurge Resurge Resurge Reviews Weight Loss Resurge Supplement Review Resurge Weight L 2025

Tips for Success on the Real Shark Tank Keto Diet

While the Real Shark Tank Keto diet can be incredibly effective for weight loss and overall health, it does require some planning and commitment. Here are some tips to help you succeed on the Real Shark Tank Keto diet:

1. Plan ahead: Stock up on keto-friendly foods such as avocados, nuts, seeds, and fatty cuts of meat to ensure you always have a healthy option on hand.

2. Stay hydrated: Drink plenty of water throughout the day to help support your metabolism and keep you feeling full and satisfied.

3. Monitor your macros: Keep track of your carbohydrate, fat, and protein intake to ensure you are staying within the parameters of the Real Shark Tank Keto diet.

Potential Risks of the Real Shark Tank Keto Diet

While the Real Shark Tank Keto diet can offer many benefits, it is not without its potential risks. One of the most common side effects of the keto diet is the “keto flu,” which can cause symptoms such as fatigue, dizziness, and irritability as your body adjusts to using ketones for fuel.

Additionally, some people may experience digestive issues such as constipation or diarrhea when first starting the Real Shark Tank Keto diet. These symptoms typically subside as your body adapts to the new way of eating, but it is essential to stay hydrated and consume plenty of fiber-rich foods to support healthy digestion.

Some people may also experience an increase in cholesterol levels when following the Real Shark Tank Keto diet, although this typically involves an increase in “good” cholesterol (HDL) rather than “bad” cholesterol (LDL). It is essential to monitor your cholesterol levels regularly and consult with a healthcare provider if you have any concerns.