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Partial or biased agonism to improve GLP-1 receptor agonist properties by Ben Jones, Clinical Senior Lecturer Imperial College London I will discuss our work aiming to understand whether the therapeutic properties and side effect profile of GLP-1R agonism can be improved by refining intracellular signalling properties. Ben Jones is a Clinical Senior Lecturer within the Section of Endocrinology and Investigative Medicine, and a Consultant in Metabolic Medicine based in Imperial College Healthcare NHS Trust and North West London Pathology. His research is focused on the translational pharmacology of G protein coupled receptors in metabolic disease. He completed his undergraduate medical training at the University of Cambridge in 2006, and was a Foundation and Core Medical trainee on the Cambridge and Oxford rotations, respectively. In 2010 he moved to Imperial as an Academic Clinical Fellow in Metabolic Medicine. He was awarded an MRC-funded Clinical Research Training Fellowship in 2013 (supervisors: Prof Steve Bloom and Prof Tricia Tan), during which he applied the emerging concept of "biased agonism" to the GLP-1 receptor. After completing clinical training in 2020 he has was awarded the Imperial Post-Doctoral, Post-CCT Fellowship (IPPRF), and subsequently an MRC Clinician Scientist Fellowship. Current work aims to establish the mechanism of action of “biased” incretin receptor agonists, and how their unusual effects can be exploited therapeutically in diabetes and obesity. https://thelongevityforum.com
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most of my clients come to me looking for a quick plan that will magically speed up their metabolism and get them their dream body in JUST 4 weeks
but I have to remind them unless they want to be in a never-ending cycle of stopping and starting
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#metabolism Here are my social media handles:
📸 Instagram: https://www.instagram.com/jamielynnlifts/
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Learn more about becoming an Insider on my website: https://www.benbikman.com In today's episode of The Metabolic Classroom, Dr. Ben Bikman delves into the fascinating topic of GLP-1, a hormone of significant interest in metabolic research. Dr. Bikman sets the stage by expanding the discussion beyond GLP-1 to include other incretions, defining them as a class of hormones produced by the small intestine. These hormones play crucial roles in nutrient metabolism, satiety, and hunger regulation. The discovery of incretions stemmed from observations following gastric bypass surgeries, where elevated levels of these hormones were found in the bloodstream, leading to improvements in diabetes. Dr. Bikman highlights GLP-1's well-known effect on insulin secretion and glucagon suppression, which contribute to its ability to rapidly correct high glucose levels and improve diabetes. However, he notes the ongoing debate regarding GLP-1's direct insulin secretagogue effect in humans, contrasting findings from cell culture and animal models with recent human studies. Moving beyond GLP-1, Dr. Bikman discusses other incretions like GIP, PYY, and cholecystokinin, outlining their roles in glucose regulation, appetite control, and digestion. He explores the pharmacological applications of GLP-1 agonists in managing diabetes and obesity, detailing various drugs and their mechanisms of action. Furthermore, he touches upon natural methods to enhance GLP-1 secretion, including dietary factors like protein, fat, and sugars. The session concludes with insights into the live Q&A session, emphasizing the dynamic interaction between science and audience participation in The Metabolic Classroom. Learn more at: https://www.insuliniq.com #insulin #insulinresistance #type1diabetes #type2diabetes #type2diabetestreatment #type2diabetesawareness #metabolichealth #metabolicsyndrome #metabolicflexibility #metabolicbalance #weightloss #weightlossdiet #weightlossdrugs #fasting #intermittantfasting #insulincontrol #timerestrictedeating #intermitentfasting #intermittentfasting
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Apple Cider Vinegar's SHOCKING Health Benefits You Never Knew! Did you know that apple cider vinegar is a powerful ally for your health? In this video, we reveal 10 incredible benefits of apple cider vinegar, from improving digestion to boosting your immune system. Learn how this natural ingredient can transform your well-being and the best ways to include it in your daily routine. 👉 Is it good for weight loss? Does it help regulate blood sugar? We answer all your questions. ⚠️ Warning: We also discuss the potential risks of overconsumption and how to avoid them. 🔔 Subscribe to the channel for more tips on healthy eating and wellness. 💬 Share your thoughts: Do you use apple cider vinegar in your daily life? apple cider vinegar weight loss,apple cider vinegar,apple cider vinegar for weight loss,apple cider vinegar benefits,apple cider vinegar uses,apple cider vinegar drink,weight loss,benefits of apple cider vinegar,apple cider vinegar health benefits,health benefits of apple cider vinegar,when to drink apple cider vinegar,apple cider vinegar diet,apple cider vinegar weight loss drink,apple cider vinegar gummies,drink apple cider vinegar to lose weight #AppleCiderVinegar #HealthBenefits #HealthyEating