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There has been plenty of talk about the need to do lots of steps, with lots of us regularly checking our devices to see how many steps we have achieved in day. If you have ever recorded your steps you will know that it actually quite difficult to reach the much talked about 10,000 steps in one day, especially if you have a fairly sedentary job. Most of us lead very busy lives and we have to put a lot of our time and energy into our work. We all need to figure out how to squeeze an effective fitness routine into the limited time that we have available? The good news is that HIIT looks like it might be a shortcut to fitness which doesn’t take anywhere nearly as much of our time as 10,000 steps. HIIT, or high-intensity interval training, is a training technique in which you give 100% effort through quick, intense bursts of exercise, followed by short, sometimes active, recovery periods. This type of training gets and keeps your heart rate up and burns more fat in less time. HIIT increases the body’s need for oxygen during the effort creating an oxygen shortage. Your body compensates by demanding more oxygen during recover. This effect is called’ excess [post-exercise oxygen consumption is the key reason why intense exercise is more effective at burning fat than slower, steadier exercise. --- Dr. Palaniappan Manickam MD, MPH Internal Medicine | Gastroenterology | Epidemiologist --- For Tamil videos, please subscribe to my Tamil channel: https://www.youtube.com/channel/UCYxezj89xof3XRLFqly20VA Like us on Facebook: https://www.facebook.com/Dr-Pal-102856268051377 Follow us on Instagram: https://www.instagram.com/dr.pal.manickam/ Follow us on Twitter: https://twitter.com/drpal_manickam Join us on Telegram: https://t.me/Ask_Doc_Pal Email: [email protected] If you want to donate to AISHWARYAM TRUST, here are the details. Website: https://aishwaryamtrust.com/

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Summary: Can Ozempic-like drugs help treat Parkinson’s disease? A new study says no—at least not yet. In this episode, we unpack the results of a major clinical trial that tested exenatide, a GLP-1 drug, in nearly 200 people with Parkinson’s. While earlier research raised hopes, this study found no improvement in symptoms or disease progression. We explore what this means for future treatment strategies, why understanding brain mechanisms is key, and whether other GLP-1 drugs still hold promise. This conversation brings clarity to a complex and evolving area of science. Disclaimer: This podcast is intended for educational and informational purposes only. It does not substitute for professional medical advice, diagnosis, or treatment. Always speak to your healthcare provider before starting or stopping any medications, especially if you have a neurological condition such as Parkinson’s disease. Scientific References & Further Reading: The Lancet. (2024). Exenatide once weekly for 96 weeks in early Parkinson’s disease: A randomized, double-blind, placebo-controlled trial. Parkinson’s Foundation. (2024). Can GLP-1 medications help Parkinson’s disease? Michael J. Fox Foundation. (2024). Exenatide and GLP-1 drug class show mixed results in Parkinson’s research. University of Alabama at Birmingham. Expert commentaries on exenatide and neuroprotection. Nature Reviews Neurology. (2023). Incretin-based therapies in neurodegenerative diseases: Promises and pitfalls.

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