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In this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Jens Juul Holst, a renowned Danish physician and physiologist, to discuss GLP-1, a hormone transforming our understanding of metabolic health. Dr. Holst, who discovered and described GLP-1, explains its role as a gut-derived hormone that regulates appetite, insulin secretion, and digestion, offering a groundbreaking approach to managing obesity and type 2 diabetes. The conversation explores how GLP-1 receptor agonists, have evolved into powerful medications. These drugs help patients achieve significant weight loss, reverse diabetes, improve cardiovascular health, reduce inflammation, and potentially enhance cognitive function. Dr. Holst delves into their long-term implications for preventing diabetes, extending health spans, and even reducing the risks of obesity-related cancers and improving fertility. Dr. Holst emphasizes that while GLP-1 offers life-changing benefits, sustainable health still hinges on balanced diets and regular physical activity. This episode provides a fascinating look at the intersection of science, medicine, and lifestyle in promoting longevity. Sign up for updates about each new episode: https://info.insidetracker.com/longevitybydesign View show notes here: https://blog.insidetracker.com/longevity-by-design-podcast-jens-juul-holst Episode highlights: Introduction: 00:00:00 What is GLP-1: 00:03:00 what is a GLP-1 agonist: 00:04:15 what are the target organs of the GLP-1 agonist?: 00:06:30 what is the effect of the GLP-1 agonist on a diabetic patient? : 00:10:00 What percentage of a diabetic patient on GLP-1 have complete remission: 00:11:30 How long did it take to bring a drug to market from the moment you first discovered it: 00:23:30 What is the GLP-1 effect on cognition and dementia: 00:29:00 GLP-1 effect on kidney diseases: 00:32:00 GLP-1 positive effect on fertility: 00:35:00 GLP-1 positive effect on cancer: 00:37:30 Should a patient be on GLP-1 for life: 00:41:00 GLP-1 related side effects: 00:48:00 GLP-1 effect on resting heart rate: 00:52:30 GLP-1 related side effects: 00:48:00 GLP-1 from Lilly vs novo nordisk: 00:55:00 GLP-1 oral versus the injectable: 00:58:00 GLP-1 effect on lifespan: 01:00:30 GLP-1 effect on lifespan: 01:00:30 What led you to become a scientist: 01:03:00 The story of discovering the GLP-1: 01:04:30 How did you successfully extend the half-life of the GLP-1 agonist: 01:09:00 GLP-1 moving from once a day to once a week: 01:16:00 Top tip to improve healthspan: 01:18:00 GLP-1 Agonists: A Game-Changer for Diabetes and Obesity Dr. Jens Juul Holst explores the revolutionary impact of GLP-1 agonists in treating diabetes and obesity. These medications mimic a natural gut hormone to regulate insulin secretion, appetite, and weight. Through their ability to normalize blood glucose levels and promote significant weight loss, GLP-1 agonists have transformed the lives of patients with type 2 diabetes and obesity. Holst highlights their success in enabling over 50% of diabetes patients to achieve normal glucose levels while addressing the systemic health risks tied to obesity. This innovation represents a monumental leap in metabolic disease management. Beyond Weight Loss: Cardiovascular and Inflammatory Benefits of GLP-1 Dr. Holst emphasizes the additional health advantages of GLP-1 agonists, beyond their effects on diabetes and obesity. These drugs improve cardiovascular outcomes by reducing major adverse events such as heart attacks and strokes. They also decrease systemic inflammation, a common issue in metabolic diseases. Holst points out that GLP-1 therapy’s dual action on vascular health and inflammation positions it as a comprehensive solution for improving long-term health outcomes in patients with diabetes or obesity.   The Impact of GLP-1 on Fertility Dr. Holst explores GLP-1’s surprising potential in fertility treatments, particularly for individuals with metabolic-related infertility issues, such as polycystic ovary syndrome (PCOS). He explains that improving metabolism and reducing insulin resistance with GLP-1 therapy can enhance fertility outcomes for both men and women. Although he urges caution due to limited long-term data, Holst notes the promising effects observed in clinical experiences. “If you can ameliorate the metabolism of these individuals, they will immediately become pregnant. And we knew that already. You can even do it with metformin…Once GLP-1s were introduced, it turned out that yes, these people became pregnant.” We Appreciate You! As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

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Over the years, the ketogenic diet has gained immense popularity for its ability to help individuals lose weight and improve their overall health. The keto diet, as it’s commonly known, focuses on low-carb, high-fat foods that help the body enter a state of ketosis, where it burns fat for energy instead of carbs. This revolutionary diet has paved the way for many keto innovations, some of which have been featured on the hit TV show Shark Tank.

Keto Innovations on Shark Tank

Shark Tank, a popular reality TV show where entrepreneurs pitch their business ideas to a panel of investors (the “sharks”), has seen its fair share of keto innovations. These innovative products aim to make following the keto diet easier and more convenient for individuals looking to improve their health and well-being. Let’s take a closer look at some of the keto innovations that have appeared on Shark Tank.

Fat Snax

Fat Snax is a keto-friendly snack company that offers a variety of delicious treats that are low in carbs and high in fats. Founded by two friends who were looking for healthier snacking options while following the keto diet, Fat Snax has quickly become a favorite among keto enthusiasts. Their cookies, crackers, and brownies are not only tasty but also free of grains and sugar, making them the perfect guilt-free treat for anyone on the keto diet.

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Nui

Nui is another keto-friendly snack company that was featured on Shark Tank. Founded by a couple who wanted to create delicious treats that didn’t compromise on taste or health, Nui offers a range of cookies that are low in carbs and high in fats. Their cookies are made with natural ingredients like almond flour, coconut oil, and cocoa butter, ensuring that they not only satisfy your sweet tooth but also keep you on track with your keto goals.

The Honest Stand

The Honest Stand is a keto-friendly food company that offers a variety of dairy-free, plant-based cheese alternatives that are perfect for anyone following the keto diet. Their products, which include nacho cheese, queso, and Alfredo sauce, are made with organic veggies and cashews, making them a healthier alternative to traditional dairy-based cheeses. The Honest Stand’s delicious and creamy cheese alternatives have become a staple in many keto kitchens, proving that you don’t have to sacrifice flavor for health.

Wild Earth

Wild Earth is a plant-based pet food company that offers sustainable and healthy food options for dogs. While not directly related to the keto diet, Wild Earth’s products align with the principles of a low-carb, high-fat diet. Their protein-rich dog food is made with ingredients like yeast, chickpeas, and sweet potatoes, providing a nutritious and eco-friendly option for pet owners who want to feed their furry friends a diet that’s in line with their own keto lifestyle.

Bubba’s Fine Foods

Bubba’s Fine Foods is a keto-friendly snack company that specializes in grain-free, paleo snacks that are perfect for anyone following the keto diet. Their products, which include snack mixes, granola, and snack bars, are made with real food ingredients like nuts, seeds, and coconut oil, making them a healthy and satisfying option for anyone looking to curb their cravings while staying on track with their keto goals. Bubba’s Fine Foods has gained a loyal following among keto enthusiasts who appreciate the company’s commitment to providing tasty and convenient snacks that support their low-carb lifestyle.

Summary

In conclusion, Shark Tank has been a platform for showcasing some of the most innovative keto-friendly products and companies that are helping individuals follow the ketogenic diet more easily. From snacks and treats to plant-based cheese alternatives and pet food, these keto innovations are changing the way people approach their health and nutrition. Whether you’re a seasoned keto veteran or just starting out on your keto journey, these products featured on Shark Tank can help you stay on track and achieve your health and wellness goals.

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