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Weight loss drugs Ozempic, Wegovy and Mounjaro have been all over the headlines. What do they do, how do they work and are they safe? A look at Ozempic, Wegovy and Mounjaro (Semaglutide & tirzepatide, GLP-1 mimetics) for obesity and weight loss. Dr. Nadolsky: Twitter: https://twitter.com/DrNadolsky https://drspencer.com IG: @drnadolsky Connect with me: Facebook: https://www.facebook.com/DrGilCarvalho/ Twitter: https://twitter.com/NutritionMadeS3 Animations: Even Topland @toplandmedia References: 1-https://www.sciencedirect.com/science/article/abs/pii/S2213858715004829 2-https://journals.physiology.org/doi/full/10.1152/ajpendo.1997.273.5.E981 3-https://link.springer.com/article/10.1007/s11154-014-9289-5 4-https://www.nature.com/articles/nrd1828 5-https://www.nejm.org/doi/full/10.1056/NEJMoa2032183 https://www.nejm.org/doi/full/10.1056/NEJMoa2206038 6-https://jamanetwork.com/journals/jama/article-abstract/2787907 7-https://www.sciencedirect.com/science/article/pii/S1043276020300485 8-https://www.hindawi.com/journals/jdr/2012/764017/ 9-https://dom-pubs.onlinelibrary.wiley.com/doi/full/10.1111/dom.14551 10-https://www.frontiersin.org/articles/10.3389/fphar.2018.00576/full 11-https://journals.sagepub.com/doi/pdf/10.1177/0192623312472402 12-https://www.frontiersin.org/articles/10.3389/fendo.2021.645563/full 13-https://www.nejm.org/doi/full/10.1056/NEJMoa2032183 14-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089287/ 15-https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14725 16-https://www.nature.com/articles/s41591-022-02026-4 Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!. #NutritionMadeSimple #GilCarvalho 0:00 Intro 0:26 COIs 3:14 New weight loss drugs 9.32 Efficacy 11:06 Dual effect of tirzepatide 13:49 What patients report 17:30 Stigma and perception 22:34 Obesity and the brain 23:46 Side effects 34:45 Fat mass vs lean mass 41:24 Do you have to take them forever?

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Paper: https://doi.org/10.1126%2Fscience.adj2537 Chapters 0:00 – Culinary Kryptonite 1:06 – GLP-1 preingestive satiation 2:46 – DMH is the brain region involved in preingestive satiation 4:14 – Heterogeneity: Rainbows and Froot Loops 5:58 – Anti-Responder? 7:13 – There’s always room for ice cream 10:29 – My prescriptions Optogenetics breakdown (go to 3 min 19 sec) in this video: https://youtu.be/44qM9VtNAjc Video Sponsor(s) - House of Macadamia and RxSugar Yes, I’m wearing a Mac Monster Macadamia Nut Shirt! I’ve been a heavy user of highly satiating macadamia nuts for over 5 years since I started a ketogenic diet. They’re delicious, versatile, high MUFA, high Omega-7/Palmitoleic Acid, low Omega-6/Linoleic acid, and low oxalate, phytate and lectin. To try product from my favorite nut company, HouseOfMacadamia, Go To: http://partner.houseofmacadamias.com/nick-norwitz - 15% Off All Bundles - 10% off any item (non-bundle) with code "NICK10" And for more information on macadamia nutrition and Omega-7: https://youtu.be/Vngn6i-rmZI I'm also on the scientific advisory board at RxSugar, a company that specializes in allulose. Unlike macadamia - which I do consume regularly - I don't have much of a sweet tooth so don't find I have much of a need for allulose. However, I always try my best to separate my personal preferences from the science, which is why I'm happy and proud to support RxSugar and their mission to displace fructose and sugar in the food supply with allulose! Among allulose's interesting properties is that it induces the release of endogenous GLP-1, albeit at lower dose equivalencies than prescription medications. Still, there are data (clinical and preclinical) that allulose can have anti-obesogenic properties. And the precise mechanism is being explored actively! There are also clinical reports of people have loss of cravings and "food noise" with allulose products, which is interesting. I wonder if one could measure a change in DMH pre-ingestion satiation neurons after an allulose bolus... perhaps we will find out in time! You can use my discount code NICK20 for 20% off any products. https://rxsugar.com For more scientific information on allulose, go here: https://youtu.be/pr93EsEV2bM

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