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Oral GLP-1 agonists—like oral semaglutide—are poised to transform the future of obesity and type 2 diabetes treatment. But how close are we to seeing these medications approved and widely available?
In this video, we explore the following: How close are we to oral GLP-1s?
Will we ever see ozempic and mounjaro tablets? If so, when? Will Eli Lilly, Novo Nordisk or someone else be first to market?
Links:
Pfizer’s press release discontinuing research on their candidate molecule: https://www.pfizer.com/news/press-release/press-release-detail/pfizer-provides-update-oral-glp-1-receptor-agonist
Eli Lilly’s April press release on Orfoglipron https://investor.lilly.com/news-releases/news-release-details/lillys-oral-glp-1-orforglipron-demonstrated-statistically#:~:text=News%20Release-,Lilly's%20oral%20GLP%2D1%2C%20orforglipron%2C%20demonstrated%20statistically%20significant%20efficacy,orforglipron%20worldwide%20without%20supply%20constraints.
And their follow-up press release on having these results prublished in the New England Journal of Medicine: https://investor.lilly.com/news-releases/news-release-details/lillys-oral-glp-1-orforglipron-showed-compelling-efficacy-and#:~:text=Lilly's%20oral%20GLP%2D1%2C%20orforglipron,Medicine%20%7C%20Eli%20Lilly%20and%20Company
NovoNordisk’s progress as of May 2025: https://www.reuters.com/sustainability/boards-policy-regulation/us-fda-accepts-novo-nordisks-application-oral-wegovy-2025-05-02/
Animal study linking *liraglutide* with thyroid cancer, suggesting it may be species-specific https://academic.oup.com/endo/article-abstract/151/4/1473/2456651?redirectedFrom=fulltext&login=false
Timestamps:
Timeline for getting a new drug to market [00:28]
Who is developing oral GLP-1 agonists? [01:22]
Eli Lilly - Orforglipron [02:22]
Novo Nordisk - Rybelsus (semaglutide) and NN-9932 [04:42]
What else is brewing (“The best of the rest”) [06:11]
Okay, so you’ve hear a little something about ozempic, wegovy and the gang, a group of utterly revolutionary large molecules that can help aid in really significant weight loss through a series of injections helping to curb appetite and slow gastric emptying, making you feel fuller for longer, wouldn’t it be neat if this came as a tablet?
Eli Lilly and Novo Nordisk think so.
Eli Lilly, producer of Mounjaro and Zepbound has one drug in Phase III trials, orforglipron, with results coming out from last month and expected to keep rolling in for the rest of the year and the start of next. After which, we may see it launched as an oral medication for both diabetes and weight loss
Novonordisk, already has an oral medication FDA approved but only for the management of diabetes, Rybelsus
Eli Lilly have over 6,000 people enrolled in ACHIEVE phase 3 trial that is investigating orforglipron as a diabetes medicine and intend to publish the rest of the data in late 2025 and 2026. They are also running their phase 3 trials investigating its efficacy as a weight management drug under the name ATTAIN and expect to submit to the FDA and other global regulatory bodies before the end of 2025, meaning that if the trials continue to come in with positive results and the FDA are happy, Eli Lilly will be bringing an oral weight loss drug to market around the middle of 2026.
as for Novo, they’ve been a lot quieter with their press releases of late
Rybelsus, its an oral formulation of Novo Nordisk’s semaglutide molecule, which has proven itself effective time and time again in injection form under brands, Ozempic and Wegovy. Its already out there in the US and Europe and works, though the weight loss effects appear to be about half that of Wegovy. clinical studies have found that increasing the dose increases the weight loss achieved, with one 68-week study finding a 50mg daily oral dose led to 15% weight loss, again, linked down below.
the best of the rest: On April 14, Pfizer announced the termination of the development of an attempt at an oral obesity medication after the molecule, named danuglipron, was found to damage the livers of a participant of a phase 2 trial.
HRS9531, published their phase 2 trial outcomes in June 2024, finding that, in a study of 249 patients a 6.0mg INJECTION lead to an average weightloss of 16% in just 26 weeks in obese, non-diabetic participants. The phase two trial is linked down below
https://diabetesjournals.org/diabetes/article/73/Supplement_1/1861-LB/155203/1861-LB-Efficacy-and-Safety-of-HRS9531-a-Novel
Both Eli Lilly and Novo Nordisk are near the final hurdle, so, oral weight loss medications of the GLP-1 agonists may be arrive early 2026.
** All the information contained in this video is not intended nor implied to constitute professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general informational purposes only and does not replace a consultation with your own doctor/health professional **
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In this episode I speak with Hal Cranmer who owns four assisted living facilities in the USA.
After discovering the power of a ketogenic carnivore diet and other healthy living practices for himself, Hal decided to test it on his residents. The results have been insane!
Hal explains how he helps the residents make these major lifestyle and diet changes, his specific protocols and the incredible results he has achieved.
This is an inspiring conversation and I'm really grateful to Hal for his time.
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Learn more about Hal here: https://aparadiseforparents.com/hal-cranmer/
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Start the carnivore diet now! https://www.howtocarnivore.com/
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Real customer Alissa shares her weight loss journey and experience with Weight Loss by Hers. Learn more about how Alissa lost 20+ pounds with oral weight loss medication kits through Hers.
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Shark Tank has become a cultural phenomenon that showcases entrepreneurs pitching their business ideas to a panel of wealthy investors in the hopes of securing a deal. One particularly memorable episode featured Anna and Samantha Martin, sisters who presented their keto diet pills on the show. Their pitch was met with skepticism from the sharks, but ultimately, they managed to secure a deal with one of the investors. However, what viewers may not know is the real story behind the episode and the controversy that followed.
The Concept of Keto Diet Pills
The keto diet has gained popularity in recent years for its potential to help with weight loss and improve overall health. The diet focuses on consuming high amounts of healthy fats, moderate protein, and low carbohydrates to achieve a state of ketosis, where the body burns fat for fuel instead of glucose. Keto diet pills claim to help accelerate the process of ketosis and promote weight loss by providing the body with exogenous ketones, which can help suppress appetite and increase energy levels.
Anna and Samantha Martin were inspired to create their own keto diet pills after experiencing success with the diet themselves. They saw an opportunity to fill a need in the market for a convenient and effective way to support weight loss and overall health while following the keto diet. The sisters spent months researching and developing their formula, working with experts to ensure the quality and effectiveness of their product.
When they appeared on Shark Tank, Anna and Samantha Martin were confident in their product and its ability to help people achieve their weight loss goals. However, they faced tough questions from the sharks about the science behind their product, the potential side effects, and the competition in the market. Despite the skepticism, the sisters were able to showcase the success stories of customers who had tried their keto diet pills and were thrilled with the results.
Deal with a Shark
One of the investors on Shark Tank, who saw the potential in Anna and Samantha Martin’s keto diet pills, made an offer to invest in their business. The deal involved a partnership that would help the sisters scale their product and reach a wider audience. While the terms of the deal were not disclosed on the show, it was clear that the investor believed in the sisters’ vision and the effectiveness of their product.
After striking a deal on Shark Tank, Anna and Samantha Martin’s keto diet pills gained even more attention and popularity. The exposure from the show helped them attract new customers and expand their business beyond what they had imagined. They continued to receive positive feedback from users who praised the pills for their effectiveness in supporting weight loss and overall well-being.
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Despite the success of their business, Anna and Samantha Martin faced criticism and scrutiny from skeptics who questioned the legitimacy of their keto diet pills. Some claimed that the product was a scam or that it did not deliver on its promises. The sisters defended their product, citing the positive feedback from customers and the science behind their formula. They remained dedicated to helping people achieve their weight loss goals and improve their health through the keto diet.
The Legacy of Anna and Samantha Martin
Anna and Samantha Martin’s appearance on Shark Tank marked a turning point in their entrepreneurial journey. The exposure and investment from the show helped them take their business to new heights and reach a wider audience. Their keto diet pills gained a loyal following of customers who were thrilled with the results and continued to support the sisters’ mission to help others achieve their weight loss goals.
While the controversy surrounding their product may have cast a shadow on their success, Anna and Samantha Martin remained committed to their vision and the quality of their keto diet pills. They continued to innovate and improve their formula, listening to feedback from customers and experts to ensure that their product was effective and safe. The sisters proved that with hard work, dedication, and a belief in their mission, anything is possible.
Overall, Anna and Samantha Martin’s journey on Shark Tank serves as a reminder of the power of perseverance and passion in the face of adversity. Despite the challenges they faced, the sisters never wavered in their commitment to helping others live healthier and happier lives. Their legacy lives on through their keto diet pills, which continue to inspire and empower people to take control of their health and achieve their weight loss goals.