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Key Points Question Are glucagon-like peptide-1 receptor agonists semaglutide and liraglutide, which were originally introduced for the treatment of type 2 diabetes and are frequently prescribed due to their weight loss properties, associated with disproportionately increased reporting of suicidality? Findings This disproportionality analysis through the case-control design based on the World Health Organization global database collecting suspected adverse drug reactions, identified a disproportionality signal of suicidal ideation with semaglutide, which remained significant when comparing semaglutide with dapagliflozin and metformin and in the subgroup of patients with coreported use of antidepressants and benzodiazepines. Meaning A detected signal of semaglutide-associated suicidal ideation warrants urgent clarification. Abstract Importance Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have gained use primarily due to their weight-reduction effects, although a regulatory review was undertaken for potential suicidality concern. Objectives To evaluate potential signals for suicidal and self-injurious adverse drug reactions (ADRs) associated with the GLP-1 RAs semaglutide and liraglutide. Design, Setting, and Participants Disproportionality analysis through the case-control design using the World Health Organization (WHO) global database of suspected ADRs. Participants were clinical patients worldwide experiencing an ADR suspectedly attributable to semaglutide or liraglutide in the database from inception to August 30, 2023. Data were analyzed from September to December 2023. Exposure Treatment with semaglutide or liraglutide regardless of indication or treatment duration. Main Outcomes and Measures Reporting odds ratio (ROR) and the bayesian information component (IC) with 95% CIs were calculated as measures of disproportionate reporting of suicidal and self-injurious ADRs associated with semaglutide and liraglutide compared with all other medications. Sensitivity analyses were conducted including patients with coreported use of antidepressants and benzodiazepines and using dapagliflozin, metformin, and orlistat as comparators. A disproportionality signal was considered when the lower limits of the ROR and IC were above 1 and 0, respectively. Results A total of 107 (median [IQR] age 48 [40-56] years; 59 female patients [55%]) and 162 (median [IQR] age 47 [38-60] years; 100 female patients [61%]) cases of suicidal and/or self-injurious ADRs were reported between November 2000 and August 2023 with semaglutide and liraglutide, respectively. Significant disproportionality was detected only for semaglutide-associated suicidal ideation (ROR, 1.45; 95% CI, 1.18-1.77; IC, 0.53; 95% CI, 0.19-0.78), which remained significant in patients with coreported use of antidepressants (ROR, 4.45; 95% CI, 2.52-7.86; IC, 1.96; 95% CI, 0.98-2.63) and benzodiazepines (ROR, 4.07; 95% CI, 1.69-9.82; IC, 1.67; 95% CI, 0.11-2.65), when compared with dapagliflozin (ROR, 5.56; 95% CI, 3.23-9.60; IC, 0.70; 95% CI, 0.36-0.95), metformin (ROR, 3.86; 95% CI, 2.91-5.12; IC, 1.20; 95% CI, 0.94-1.53) and orlistat (ROR, 4.24; 95% CI, 2.69-6.69; IC, 0.70; 95% CI, 0.36-0.95). Conclusions and Relevance This study using the WHO database found a signal of semaglutide-associated suicidal ideation, which warrants urgent clarification.
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Semaglutide Vs Mounjaro For Weight Loss Comparing Effectiveness
▶It targets to lose belly fat & waist and total abs for getting smaller waist and toned your abdominal muscles. ▶This total abs & belly fat workout might be intense but highly effective to get flat stomach. ▶For beginners : When you do 'Side Plank Hip Drops' Lie on your side with your knees bent, and prop your upper body up on your elbow. Or you can start with my beginners workout program ( on the playlist) ▶Calories: It Burns between 50 ~ 80 Calories (Depends on weight, height, body composition, muscle mass, intensity of exercises) ◈For better results This 8 min total ab workout can totally be effective to get flat stomach, as long as you’re combining this with healthy meal and my fat burn full body workout😊 It takes at least 2 ~ 4 weeks for weight loss. As I always say, everyone's physical condition, genes and bone structure are different, so results can be varied. Depending on the intensity and the consistency of your workout, also, it will take more than 4 weeks for your abs muscles to get toned. ▷▶Slim Thighs (Gap) & Legs workout https://youtu.be/dCfdWPWRg14 ▷▶Full Body (Jumping & No Jumping ) https://youtu.be/vaq7YpCwH7M https://youtu.be/yZ_GeAfD0k4 https://youtu.be/yZ_GeAfD0k4 ▷▶Upper Body (Arms, Armpit, Chest, Shoulder, Back) https://youtu.be/hro_uUsSKhM ▷▶Love Handles https://youtu.be/w4ugye7Iab8 https://youtu.be/jetBPoy-RDQ https://youtu.be/8nOby2bK07c ■For Skinny Body: For the best way to tone and sculpt your body without losing weight, it is important to eat the right foods and stay hydrated—your muscles depend on it and, eat foods high in protein with this workout. - Have a Balanced Eating Habits - Eat more protein at every meal. - Work out different areas (focus on more muscles strengthening exercise than cardio) - Before working out 5-10 min cardio warm up; It boost your blood moving and can help increase your flexibility. ♡♥For teenagers: It's important for teens to lose weight the healthy way by making diet and lifestyle changes that nourish growing bodies and can be followed long term. 1)firstly think healthy eating plan, not diet; Fruits and vegetables every day. .. ( healthy eating doesn't mean going hungry) 2)Do home workout 30 to 60 minutes a day three or four days a week—that's a start, including full body cardio workout and aerobic activity are running, swimming, and dancing(not too much) 3) Get enough sleep 4)Protein to build muscles and organs 5)Love yourself ▷▶Full Body (Jumping & No Jumping ) https://youtu.be/vaq7YpCwH7M https://youtu.be/yZ_GeAfD0k4 https://youtu.be/yZ_GeAfD0k4 ▶About my physical conditions 나의 신체정보 1) Height: 164cm. 2) Weight: 44kg ~ 45kg (varies from morning and night) 3)Body Type: Mesomorph ▣Q&A VIDEO About Me: https://youtu.be/ZN2UbtIuZco ♥WORKOUT PROGRAM & DIET MEAL PLAN 몸매관리 식단 및 운동플랜표 https://www.instagram.com/fitn_youngsy/ https://www.youtube.com/channel/UCy9E... ▶My Links https://www.instagram.com/fitn_youngsy/ https://www.facebook.com/shirlyn.kim ▶Music By https://www.epidemicsound.com/music/f... ▶▶Upload day: Every Monday (Korean Standard Time) Thanks for watching my video and hope you guys enjoy it. Love from Korea. ※Disclaimer This workout video on my YouTube channel is the one that I personally do to stay fit and healthy at home. When joining me for this workout video, check your health and safety with experts first since they are the most important. I am not responsible for any injuries and risks arising from this workout video.
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