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Are your patients wasting away? Dr Tamaan Osbourne-Roberts explains why lifestyle interventions are a key supplement to GLP-1 agonists for weight management. https://www.medscape.com/viewarticle/muscle-wasting-glp-1-agonists-pound-prevention-worth-pound-2025a10008ja?src=soc_yt -- TRANSCRIPT -- I'm Tamaan Osbourne-Roberts, family physician and lifestyle medicine physician. Today we're talking about glucagon-like peptide 1 (GLP-1) receptor agonists and muscle wasting: why lifestyle medicine still matters. With the advent of GLP-1 agonists (and the occasional and only partially farcical suggestion that we should just be putting them in the water), there has been some debate as to whether lifestyle interventions still play a role in weight management as either primary or secondary interventions. The answer, unequivocally, is yes. Today, let's explore the role of these interventions to combat one particular and common side effect of GLP-1 agonists — muscle wasting. As many of us know, the weight loss associated with long-term GLP-1 agonist use is not limited to fat mass; lean muscle mass can be lost as well. Combating this muscle loss requires a concerted effort involving both diet and exercise. Given the decreased overall consumption of calories that occurs with these medications, counseling patients extensively on adopting or adhering to a nutrient-dense, healthy, high-protein diet is essential. Discussing strategies for incorporating plant-based proteins into their diet is particularly important. Similarly, prescribing muscle building exercise regimens, such as weight resistance training or body weight resistance exercise, is a hallmark of lifestyle-based interventions in these cases. Taking the time to counsel patients on these items in a preventive manner is particularly helpful. As we all know, an ounce of prevention is worth a pound of cure. If you have the time and expertise to do so at the primary care level — go for it. But don't be afraid to refer to your local obesity or lifestyle medicine specialist for assistance. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/muscle-wasting-glp-1-agonists-pound-prevention-worth-pound-2025a10008ja?src=soc_yt

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Semaglutide is a medication that has recently garnered attention for its weight loss benefits. Originally developed to treat type 2 diabetes, semaglutide has been shown to aid in weight loss when used in higher doses. While the concept of a weight loss shot may seem appealing to many, it is essential to understand the basics of how semaglutide works and what potential side effects may arise.

How Semaglutide Works

Semaglutide is a glucagon-like peptide-1 (GLP-1) analogue that works by mimicking the effects of a hormone produced in the intestines. GLP-1 helps regulate blood sugar levels and can also increase feelings of fullness, leading to reduced food intake. By injecting semaglutide, individuals may experience a decrease in appetite and a greater sense of satiety, which can contribute to weight loss over time.

Furthermore, semaglutide has also been shown to slow down stomach emptying, which can further aid in weight loss by delaying the absorption of nutrients and reducing overall caloric intake. This combination of effects makes semaglutide a unique option for those struggling to shed excess pounds.

It is important to note that semaglutide should not be seen as a standalone solution for weight loss. It should be used in conjunction with a healthy diet and regular exercise to achieve maximum results. Additionally, individual responses to semaglutide can vary, so it is crucial to consult with a healthcare provider before starting this medication.

Potential Side Effects

Like any medication, semaglutide does come with potential side effects that individuals should be aware of. Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These gastrointestinal symptoms may occur at the beginning of treatment but often improve over time as the body adjusts to the medication.

In some cases, semaglutide can also lead to more serious side effects, such as pancreatitis or kidney problems. It is essential to monitor for any signs of these complications, including severe abdominal pain, persistent vomiting, or changes in urination. If any concerning symptoms arise, it is important to seek medical attention promptly.





Additionally, semaglutide may interact with other medications or medical conditions, so it is vital to disclose all relevant information to your healthcare provider before starting treatment. By being transparent about your medical history and current medications, you can ensure the safe and effective use of semaglutide for weight loss.

Cost and Availability

One factor to consider when exploring semaglutide as a weight loss option is the cost and availability of the medication. Semaglutide is currently approved for the treatment of type 2 diabetes at lower doses, but higher doses specifically for weight loss are still undergoing clinical trials and awaiting FDA approval.

While some individuals may be able to access semaglutide off-label for weight loss, it is essential to consider the potential financial implications. Semaglutide is a prescription medication that may not be covered by insurance for weight loss purposes, leading to out-of-pocket expenses for those seeking this treatment option.

Before pursuing semaglutide for weight loss, individuals should research the availability of the medication in their area and consider the associated costs. Consulting with a healthcare provider can also provide valuable guidance on the best course of action based on individual health needs and budget considerations.

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Medicare's Game-Changing Move: Price Negotiations for Ozempic and Wegovy In this episode of The Downsized, Christopher Durham discusses the major announcement from Medicare about negotiating prices for GLP-1 medications, specifically Ozempic and Wegovy. Set to take effect in 2027, this move could significantly lower prices and impact the entire pharmaceutical industry. Christopher explores how this could influence Eli Lilly's pricing strategies for Zepbound and Mounjaro, potentially benefiting millions of patients battling diabetes and obesity. He also highlights the ongoing challenge for pharmaceutical companies like Novo Nordisk and the broader implications for drug pricing and accessibility. Don't miss this in-depth analysis of a pivotal moment in healthcare. Like, subscribe, and share your thoughts in the comments! DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8. 00:00 Introduction to Today's Topic 01:12 Breaking News: Medicare's Price Negotiations 01:57 Impact on Pharmaceutical Industry 03:25 Implications for Patients 03:47 Challenges and Future Outlook 04:25 Closing Thoughts and Community Engagement

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