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Dr. Casey Means is a leading metabolic health expert and doctor from Stanford Medical School, NIH researcher, co-founder of health tech company Levels, and author of New York Times best-selling book Good Energy. She provides a science-based, nuanced perspective on the hot topics of Ozempic, weight loss, and the underlying metabolic crisis in America. Casey and Liz discuss the distinction between obesity and metabolic health, the influence of modern lifestyles on metabolic dysfunction, and the holistic approaches needed to improve metabolic health without relying solely on medications like Ozempic or Wegovy. The conversation also explores practical strategies to enhance mitochondrial function, such as dietary adjustments, movement vs. exercise, and reducing exposure to toxins. If you're looking to understand the science behind metabolic health and gain actionable insights to improve your well-being, this episode is a must-listen. LISTEN / SUBSCRIBE TO THE PODCAST Spotify: https://open.spotify.com/show/6dBAMh1qc4ML7xxbYwYwNj?si=3f255eb8b6c74b46 Apple: https://podcasts.apple.com/us/podcast/the-liz-moody-podcast/id1398442165 Youtube: https://www.youtube.com/@lizmoodypodcast 00:00 Intro 02:24 The Obesity and Metabolic Health Debate 04:57 Understanding Different Types of Fat: Subcutaneous, Visceral, and Intracellular 06:36 Ozempic's Impact on Metabolic Health 07:56 Mitochondria and Metabolic Health 08:32 The Eight Pillars Affecting Mitochondria 12:00 Ozempic: Mechanisms and Physical Effects 26:24 Natural Ways to Boost GLP-1 and Inhibit DPP-4 30:22 The Food Industry and Cravings 37:42 The Consequences of Obesity and the Healthcare System 38:50 Personal Responsibility vs. Systemic Forces 39:43 The Impact of Policy on Health 40:53 Understanding Metabolic Health 45:09 Tracking Biomarkers for Better Health 47:34 Addressing Hidden Health Issues 58:11 The Importance of Movement vs Exercise 59:57 The Dangers of Ultra-Processed Foods 64:21 The Root Cause of Health Issues If you’re new here, I’m Liz Moody! I’m a longtime journalist, thought leader, and best-selling author. I host The Liz Moody Podcast where every week, we’re sharing real science, real stories, and realistic tools that ACTUALLY level up every part of your life. If you want to know more, visit my website or check me out on The TODAY Show with Hoda Kotb and Jenna Bush Hager: https://www.lizmoody.com https://youtu.be/pIE6JJ50CNM?si=-wnv2zF9ft9fqWZw CONNECT WITH ME Instagram: https://www.instagram.com/lizmoody/ Tiktok: https://www.tiktok.com/@lizmoody Order my book 100 Ways to Change Your Life: The Science of Leveling Up Health, Happiness, Relationships & Success: https://www.100waystochangeyourlife.com Newsletter: https://www.lizmoody.com Liz Moody Podcast Club Facebook Group: https://www.facebook.com/groups/thelizmoodypodcast CONNECT WITH DR. CASEY MEANS Website: https://www.caseymeans.com Order her book Good Energy: The Surprising Connection Between Metabolism and Limitless Health: https://www.caseymeans.com/goodenergy Instagram: https://www.instagram.com/drcaseyskitchen/ Youtube: https://www.youtube.com/channel/UCsxX_iM425PEU5VjNCZQ37g Linkedin: https://www.linkedin.com/in/casey-means-md This podcast and website represents the opinions of Liz Moody and her guests to the show. The content here should not be taken as medical advice. The content here is for information purposes only, and because each person is so unique, please consult your healthcare professional for any medical questions. The Liz Moody Podcast Episode 250. #lizmoody #lizmoodypodcast #science #health #nutrition #weightloss

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👀 Do you want to get fit without dieting or exercising by tricking your body? This sounds like sci-fi, or like a scammy ad for a fat burning supplement. However, given recent advances in exercise mimetics and strong momentum behind treating obesity pharmacologically (most notably, semaglutide - Ozempic/Wegovy and tirzepatide - Mounjaro/Zepbound), this idea could reality sooner than some expect. 🧠 In this video we will discover SLU-PP-332, a small molecule that mimics endurance training and dieting in mice - without exercise or eating less. We will cover 1) the biochemical basics of exercise mimetics and mechanisms of action, 2) take a look at pre-clinical data of different compounds, and 3) as always, review chemistry concepts. https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters!!! https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research, mechanism quizzes and interesting news! https://total-synthesis.com https://total-synthesis.com/exercise-mimetics-trick-your-body-into-burning-fat/ Disclaimer - This channel does not provide medical advice! No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube. 00:00 Trick your body into losing weight - is it possible? 01:22 Obesity problem, logic behind using drugs and limitations 02:31 GLP1 agonists 03:01 Exercise mimetic basics 04:04 Resveratrol's exercise mimicry, health benefits and unexpected effects 06:03 ERR up/downregulation can trigger major effects - transgenic and knock-out mice 09:18 Drug design logic behind SLU-PP-332 11:02 Organic synthesis of SLU-PP-332 (too easy) 11:32 Molecular, structural, physiological and metabolic effects of SLU-PP-332 15:05 Outlook and conclusion Key references: - PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism | Oxidative Medicine and Cellular Longevity, 2020, 1452696 - Caloric restriction and exercise “mimetics’’: Ready for prime time? | Pharmacological Research 2016, 103, 158 - Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha | Cell 2006, 127, 1109 - Distribution and Effects of Estrogen Receptors in Prostate Cancer: Associated Molecular Mechanisms | Frontiers in Endocrinology 2022, 12, 811578 - Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma | J Med Chem 2005, 48, 3107 - Exercise and PGC-1 alpha-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERR gamma | Cell Metabolism 2011, 13, 283 - Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness | Mol Endocrinol 2014, 28, 2060 - Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity | ACS Chem. Biol. 2023, 18, 756 - A Synthetic ERR Agonist Alleviates Metabolic Syndrome | J. Pharmacol. Exp. Ther. 2023, 001733 Another related SLU-PP compound with more chemistry information behind it: Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915 | Eur J Med Chem 2023, 258, 115582 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) - Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)