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In this journal club episode, my guest is Stanford and Johns Hopkins-trained physician, Dr. Peter Attia, M.D., who is also the host of The Drive podcast and the author of the bestselling book "Outlive: The Science & Art of Longevity."
We each present a scientific paper and discuss the findings' strengths, weaknesses and actionable takeaways.
First, we discuss an article that addresses whether taking the drug metformin can enhance longevity. Then, we discuss an article on belief effects (similar to placebo effects), showing how the effects of a drug on the brain and cognition depend on one's belief about the dose of the drug taken, not the actual dose.
Our conversation also highlights how to read, interpret and critique scientific studies. This episode ought to be of interest to those curious about health and longevity, medicine and psychology and for anyone seeking to better understand how to read and digest scientific findings.
#HubermanLab #Science
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Articles
Reassessing the evidence of a survival advantage in Type 2 diabetes treated with metformin compared with controls without diabetes: a retrospective cohort study: https://bit.ly/3EypTAJ
The Hallmarks of Aging: https://bit.ly/3ZeqnFI
Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls: https://bit.ly/3Lespjp
A thalamic circuit represents dose-like responses induced by nicotine-related beliefs in human smokers: https://bit.ly/3LiAaEX
Other Resources
TAME (Targeting Aging with Metformin) Trial: https://bit.ly/3P7eMDI
Interventions Testing Program (ITP): https://bit.ly/3EDtmOg
Slow-Carb Diet (Tim Ferris): https://bit.ly/462q6YD
Dr. Alia Crum: Science of Mindsets for Health & Performance (Huberman Lab episode): https://bit.ly/3PdbKhd
Nicotine’s Effects on the Brain & Body & How to Quit Smoking or Vaping (Huberman Lab episode): https://bit.ly/3PkGopc
Adderall, Stimulants & Modafinil for ADHD: Short- & Long-Term Effects (Huberman Lab episode): https://bit.ly/3Pg7jT3
Neural correlates of interspecies perspective taking in the post-mortem Atlantic Salmon: an argument for multiple comparisons correction (Dead salmon study): https://bit.ly/3PvJvf9
Timestamps
00:00:00 Dr. Peter Attia, Journal Club
00:03:27 Sponsors: Helix Sleep & Levels
00:06:11 Dreams
00:12:36 Article #1, Metformin, Mitochondria, Blood Glucose
00:19:47 Type 2 Diabetes & Causes, Insulin Resistance
00:25:30 Type 2 Diabetes Medications, Metformin, Geroprotection, Bannister Study
00:36:19 Sponsor: AG1
00:37:15 TAME Trial; Demographics, Twin Cohort
00:44:27 Metformin & Mortality Rate
00:51:28 Kaplan-Meier Mortality Curve, Error Bars & Significance, Statistical Power
01:01:17 Sponsor: InsideTracker
01:02:23 Hazard Ratios, Censoring
01:09:00 Metformin Advantage?, Variables, Interventions Testing Program
01:16:02 Berberine, Acarbose, SGLT2 Inhibitors
01:23:48 Blood Glucose & Energy Balance; Caloric Restriction, Aging Biomarkers
01:32:22 Tool: Reading Journal Articles, 4 Questions, Supplemental Information
01:38:10 Article #2, Belief Effects vs. Placebo Effect
01:45:22 Nicotine Effects
01:51:07 Nicotine Doses & Belief Effects, fMRI Scan
02:00:07 Biological Effects, Dose-Dependent Response & Belief Effects
02:05:14 Biology & Beliefs, Significance, Dopamine Response, Non-Smokers
02:10:57 Dose-Dependence & Beliefs, Side Effects, Nocebo Effect
02:19:06 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Neural Network Newsletter, Social Media
Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com
Disclaimer: https://hubermanlab.com/disclaimer
Losing sleep? You could be losing muscle and gaining fat—fast. In this short, Dr. Campbell reveals what research shows about the shocking effects of sleep deprivation on fat storage, metabolism, and body composition.
Sleep isn’t optional—it’s a fat-loss and muscle-saving essential.
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Bill Campbell PhD is a leading expert in physique enhancement and exercise science, dedicated to helping people optimize their body composition through evidence-based strategies. With over 20 years of research, he simplifies complex diet and training concepts to empower fitness enthusiasts, coaches, and professionals to achieve sustainable and lasting results.
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In this video, I dive deep into why you’re experiencing gut issues on a GLP-1 diet and what you can do about it. Many people blame GLP-1 peptides for gastric problems like nausea, bloating, constipation, and diarrhea, but the real issue often lies in your diet, lifestyle, and gut microbiome health. I’ll explain exactly how GLP-1 peptides affect your digestive system and why pairing them with certain diets, like high-fat keto or carnivore diets, can be disastrous. You’ll also learn practical tips for avoiding these gut problems through proper diet, supplementation, and meal timing.
Timestamps:
0:00 - Introduction: GLP-1 Peptides & Gut Dysregulation
5:08 - Why GLP-1 Causes Gut Issues
10:24 - The Problem with High-Fat Diets & GLP-1
16:24 - Candida & SIBO Explained
21:03 - Why SIBO & Candida Matter with GLP-1 Therapy
25:59 - Best Dietary Practices for GLP-1 Users
31:04 - Meal Scheduling and Eating Habits
34:07 - Microbiome Management & GLP-1 Dosing
35:34 - Summary: How to Thrive on a GLP-1 Diet
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Are you looking to improve your weight loss journey with a natural supplement? Tru Body ACV Keto Gummies might be the perfect solution for you. These gummies combine the benefits of apple cider vinegar (ACV) and keto diet principles into a convenient and delicious form. In this article, we will explore the benefits of Tru Body ACV Keto Gummies and how to use them effectively to achieve your weight loss goals.
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Tru Body ACV Keto Gummies offer a range of benefits to support your weight loss journey. Firstly, apple cider vinegar is known for its ability to promote fat burning and weight loss. It also helps to reduce appetite and increase feelings of fullness, which can aid in controlling cravings and overeating.
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To experience the benefits of Tru Body ACV Keto Gummies, it is important to use them correctly. The recommended dosage is to take 2 gummies daily, preferably with a meal. This will help your body absorb the nutrients more effectively and support your weight loss goals.
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Weight loss is a struggle, isn’t it? To achieve our goals, we often turn to the gym, strict diets, and fitness routines. But now, there’s a new trend—losing weight without workout! Sounds surprising, right? Well, Bollywood celebrities like Vidya Balan, R. Madhavan, and Himanshi Khurana have done it, and they’ve shared their tips and secrets. From intermittent fasting to anti-inflammatory diets, they’ve revealed how they made it possible. Want to know more about their weight loss journeys and how you can try these methods too? Watch our video now!
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0:00:00 - Food as Fuel is Controversial?
0:06:47 - Mind-Body Connection in Nutrition
0:14:28 - How Some People Use Food as Survival
0:17:36 - Understanding Food Relationships and Habits
0:25:12 - Healing Your Relationship to Food Through Stress Management
0:28:15 - Emotional Eating Cycles and How to Break Them
0:33:45 - Gut-Brain Connection
0:40:22 - What Self-Awareness in Eating Looks Like
0:45:00 - Holistic Approaches to Fit Your Lifestyle
0:50:30 - Unbelievable Stories of Transformation
Can food be both fuel and comfort without leading us astray? Join us as we tackle this question, exploring how food impacts not just our physical health but our emotional well-being too. Drawing inspiration from my work as a registered dietitian, we embrace the idea that food is primarily fuel, essential for our cellular functions, yet acknowledge the joy and celebration that a slice of birthday cake brings. Through candid conversations and personal anecdotes, we shed light on the importance of mindful eating and the balance required to avoid disordered eating patterns.
Our journey doesn't stop there. We investigate the profound connection between mental health and nutrition, questioning the traditional boundaries of dietetics. By sharing moving client experiences, we emphasize the necessity of addressing emotional well-being alongside dietary adjustments. We delve into the role of the gut-brain axis and the vagus nerve, exploring how poor nutrition and stress can spiral into anxiety and depression. The conversation challenges listeners to understand the importance of mental and emotional factors, advocating for a comprehensive approach to true health.
Lastly, we reflect on how our survival instincts shape our relationship with food, examining the fears surrounding hunger and abundance. With insights drawn from relationship experts, such as Esther Perel, and literary references, we explore how stress management can transform our connection with food. This episode urges listeners to consider the parallels between personal relationships and food habits, stressing the importance of self-awareness and inner power. By shifting our focus from diet to stress management, we pave the way for improved health and well-being.
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Mindful Eating, Food as Fuel, Nutrition, Mental Health, Gut-Brain Connection, Stress Management, Emotional Eating, Holistic Approach, Mind-Body Connection, Disordered Eating, Self-Healing, Traditional Dietetics, Survival Instincts, Food Relationships, Habits, Emotional Needs, Fat Misconceptions, Self-Awareness, Stress Reduction, Health and Well-being
