Several weeks ago, we briefly talked about oral semaglutide (Rybelsus) when we addressed the current concern surrounding the Wegovy shortage. And although it's currently not approved for weight loss, there is a lot buzz surrounding the hope that it soon will be, and its clinical results for weight loss have been promising. But remember, you can't always believe what you read unless there's science to back it up.
Today I'd like to talk about oral semaglutide, the current clinical studies surrounding its efficacy for weight loss, and things to consider with oral weight loss medications.
What is Rybelsus?
We've talked about Rybelsus before. It's the oral version of semaglutide. It contains the same active ingredient as Ozempic and Wegovy. Because all three of these medications have the same active ingredient, they work the same way in your body. After you eat a meal, semaglutide helps to lower your blood sugar by mimicking a gut hormone called glucagon-like peptide-1 (GLP-1). This causes your pancreas to release insulin and blocks your liver from releasing sugar. It also slows down how quickly food leaves your stomach. This makes you feel full longer and suppress your appetite. All of these things together lead to weight loss.
The most obvious difference between the medications is how they're taken. Wegovy and Ozempic are once weekly injections, while Rybelsus is a pill you have to take by mouth every day.
Like Ozempic, Rybelsus is not approved for weight loss management even though loss of appetite may occur. Currently, Rybelsus should only be used to treat type 2 diabetes.
It's also important to remember that Rybelsus comes in 3mg, 7mg, and 14mg strengths. Only patients taking the Ozempic 0.5mg dose for type 2 diabetes can switch to Rybelsus.
And, like Wegovy and Ozempic, Rybelsis can also cause similar stomach-related side effects like nausea, vomiting, diarrhea, and constipation.
What do the clinical studies show?
A 68-week study with almost 670 adult participants reported an average weight loss of nearly 15% taking oral semaglutide 50mg daily. The placebo group lost an average of 2.4% of their body weight. This is similar to the results from the largest Wegovy trial (2,000 adult participants), which showed about 15% average weight loss within the same time period.
Things to consider
Higher doses: The Rybelsus doses studied for weight loss were 50 mg daily. Currently, Rybelsus comes in 3mg, 7mg, and 14mg strengths. The manufacturer plans to request FDA approval for the 50mg dose if approved for weight loss.
Convenience: The tablets must also be taken first thing in the morning with no more than 4 ounces of water. You must wait 30 minutes before eating, drinking, or taking other medications to absorb the Rybelsus fully. Initially, injections may seem scary, but with some practice, giving yourself a shot under the skin can be painless. Often the needles used for subcutaneous injections are as thin as two strands of hair. Would you rather give yourself a weekly injection or remember to take a daily pill?
Heart benefits: Rybelsus is great for people with type 2 diabetes who don't want to give themselves injections. However, unlike Ozempic and Wegovy, Rybelsus doesn't have the same heart-related benefits (lower risk of heart attack and stroke). In fact, studies have shown to lower the risk of death due to heart problems in certain people by 26%.
Medication Interactions: Rybelsus has been shown to lower the absorption of levothyroxine (a thyroid medication) by 33%. Make sure to let your healthcare provider know your full list of medications so they can check for potential drug interactions while taking Rybelsus.
Cost: The average cash price (without prescription insurance) of Rybelsus is $1,100 for 30 tablets (3mg, 7mg, or 14mg tablets). This is lower than the average cash price of Wegovy which is about $1,500 for 4 prefilled pens. Price tags on these weight loss medications don't come cheap and, without the help of insurance, are out of reach for many. I don't anticipate the price for 50 mg Rybelsus tablets to be much better. It will likely have a similar cash price of around $1,000-1,1500 for 30 tablets.
Thanks again for listening to The Peptide Podcast, we love having you as part of our community. You can find out more information about semaglutide on our previous podcasts.
If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!
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In today’s top stories:
- The FDA says it will review clinical trials that send US citizens' cells to 'hostile countries' as the agency's leadership in this area is sidelined.
- Novo Nordisk may have inadvertently let generics of its GLP-1 drug semaglutide launch in Canada early next year, but was it actually an error?
- Patients are celebrating the first-ever FDA-approved therapy for rare and debilitating skin disorder bullous pemphigoid.
- Grail is eyeing FDA approval of its Galleri cancer screening blood test after a second positive phase 3 trial.
- Madrigal Pharma could be just weeks away from becoming the first drugmaker to claim EU approval for a MASH treatment.
Subscribe to @Pharmaphorum for daily news updates and check out www.pharmaphorum.com for more insights and analysis.
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Oprah Winfrey Unveils ACV Keto Gummies
For those who are unfamiliar, ACV stands for apple cider vinegar, a popular ingredient in many health and wellness products due to its numerous benefits. Keto, on the other hand, refers to the ketogenic diet, which has gained massive popularity in recent years for its potential to aid in weight loss and improve overall health. By combining these two powerhouse components into a convenient gummy form, Oprah has created a product that is sure to appeal to health enthusiasts everywhere.
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This episode is going to share 4 reasons you're not losing weight, especially after 50. Keeping insulin and inflammation low is the best, most effective way to lose weight, keep it off, and prevent disease. Insulin is the primary hormone responsible for your body set weight. If you want to lose weight, learn how to lower insulin.
Highlights From This Episode:
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Pillar #1: Nutrition - What You Eat
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Note: Reshape Physical Therapy and Wellness evolved into Weight Loss for Health, and finally Zivli. How to Lose Weight After 50 was our first course that eventually grew into Zivli. Some old blog posts or resources mentioned in this episode may have been removed.
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Low Carb & Sugar Lifestyle Playlist - https://www.youtube.com/playlist?list=PL5_RBZm7ejTtyqyOa8pN9w9FlMs0PV1nG
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// F O L L O W
▸ website | https://www.zivli.com/
▸ email | [email protected]
▸ apple podcasts | https://podcasts.apple.com/us/podcast/reshape-your-health-with-dr-morgan-nolte/id1494789211
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// D I S C L A I M E R
Dr. Morgan Nolte is a doctor of physical therapy and a board-certified clinical specialist in geriatric physical therapy. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Nolte and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Zivli, LLC and Morgan Nolte, PT, DPT are not liable or responsible for any advice, course of treatment, diagnosis or any conclusions drawn, services or product you obtain through this video or site.
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Welcome to our comprehensive guide on where to buy BioLife Keto Gummies! If you’re looking to purchase this popular supplement, you’ve come to the right place. BioLife Keto Gummies have been gaining popularity for their ability to support weight management and overall wellness. In this article, we will provide you with everything you need to know about purchasing BioLife Keto Gummies, including where to find them and what to look out for when making your purchase.
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